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Medical Research Methodology

  1. Content type: Research article

    Activity monitoring is important to establish accurate daily physical activity levels in children with cerebral palsy (CP). However, few studies address issues around inclusion or exclusion of step count data;...

    Authors: Nichola C. Wilson, Suzie Mudge and N. Susan Stott

    Citation: BMC Research Notes 2016 9:411

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  2. Content type: Research article

    A recent topic of interest in the blood transfusion literature is the existence of adverse effects of transfusing red cells towards the end of their storage life. This interest has been sparked by conflicting ...

    Authors: Jillian A. Patterson, Elizabeth A. Stuart and Jane B. Ford

    Citation: BMC Research Notes 2016 9:367

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  3. Content type: Research article

    Causal mediation analysis is often used to understand the impact of variables along the causal pathway of an occurrence relation. How well studies apply and report the elements of causal mediation analysis rem...

    Authors: Shao-Hsien Liu, Christine M. Ulbricht, Stavroula A. Chrysanthopoulou and Kate L. Lapane

    Citation: BMC Research Notes 2016 9:354

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  4. Content type: Research article

    In this study we explored the possibility of automating the PGP9.5 immunofluorescence staining assay for the diagnosis of small fiber neuropathy using skin punch biopsies. The laboratory developed test (LDT) w...

    Authors: Nathalie Van Acker, Michael Ragé, Ellen Sluydts, Michiel W. M. Knaapen, Martine De Bie, Maarten Timmers, Erik Fransen, Carla Duymelinck, Stefanie De Schepper, Praveen Anand, Theo Meert, Léon Plaghki and Patrick Cras

    Citation: BMC Research Notes 2016 9:280

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  5. Content type: Research article

    Critically appraising the quality of clinical practice guidelines (CPGs) is an essential element of evidence implementation. Critical appraisal considers the quality of CPG construction and reporting processes...

    Authors: Karen Grimmer, Shingai Machingaidze, Janine Dizon, Tamara Kredo, Quinette Louw and Taryn Young

    Citation: BMC Research Notes 2016 9:244

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  6. Content type: Research article

    Persons living with HIV (PLWH) and substance use/misuse experience significant barriers to engagement in HIV care at every step of the HIV care continuum including: (1) HIV testing and diagnosis (2) linkage to...

    Authors: Kamini E. Kuchinad, Heidi E. Hutton, Anne K. Monroe, Garrick Anderson, Richard D. Moore and Geetanjali Chander

    Citation: BMC Research Notes 2016 9:229

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  7. Content type: Correspondence

    Convergent validity is one type of validity that is commonly assessed for patient-reported outcome measures (PROMs). It is assessed by means of “hypothesis testing”: determining whether the scores of the instr...

    Authors: Inger L. Abma, Maroeska Rovers and Philip J. van der Wees

    Citation: BMC Research Notes 2016 9:226

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  8. Content type: Short Report

    Limitations in the primary studies constitute one important factor to be considered in the grading of recommendations assessment, development, and evaluation (GRADE) system of rating quality of evidence. Howev...

    Authors: Toshi A. Furukawa, Tomofumi Miura, Anna Chaimani, Stefan Leucht, Andrea Cipriani, Hisashi Noma, Hiroshi Mitsuyasu, Shegenobu Kanba and Georgia Salanti

    Citation: BMC Research Notes 2016 9:218

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  9. Content type: Short Report

    A cohort study was planned to evaluate vaccine immunogenicity and effect of malaria and helminth co-infections on the bivalent Human papilloma virus (HPV) vaccine. The study would involve self collected introi...

    Authors: Miriam Nakalembe, Twaha Mutyaba and Florence Mirembe

    Citation: BMC Research Notes 2016 9:170

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  10. Content type: Research Article

    During the last decade, the number of clinical trials conducted in sub-Saharan Africa has increased significantly which has helped to address priority health problems in the region. Navrongo health research ce...

    Authors: James Akazili, Samuel Chatio, Fabian Sebastian Achana, Abraham Oduro, Edmund W. Kanmiki and Frank Baiden

    Citation: BMC Research Notes 2016 9:139

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  11. Content type: Research article

    Pain intensities of patients are repeatedly measured by Visual Analog Scale (VAS) and Pain Vision (PV) in a clinical research. Two measurements by VAS and PV are performed at the same time. In order to evaluat...

    Authors: Fumiaki Kiyomi, Masako Nishikawa, Yoichiro Yoshida and Keita Noda

    Citation: BMC Research Notes 2016 9:115

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  12. Content type: Research article

    Missing data in a large scale survey presents major challenges. We focus on performing multiple imputation by chained equations when data contain multiple incomplete multi-item scales. Recent authors have pro...

    Authors: Catrin O. Plumpton, Tim Morris, Dyfrig A. Hughes and Ian R. White

    Citation: BMC Research Notes 2016 9:45

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  13. Content type: Research article

    Fishing communities are potentially suitable for Human immunodeficiency virus (HIV) efficacy trials due to their high risk profile. However, high mobility and attrition could decrease statistical power to dete...

    Authors: Andrew Abaasa, Gershim Asiki, Juliet Mpendo, Jonathan Levin, Janet Seeley, Leslie Nielsen, Ali Ssetaala, Annet Nanvubya, Jan De Bont, Pontiano Kaleebu and Anatoli Kamali

    Citation: BMC Research Notes 2015 8:815

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  14. Content type: Research article

    There is evidence that physicians’ prescription behavior is negatively affected by the extent of their interactions with pharmaceutical companies. In order to develop and implement policies and interventions f...

    Authors: Tamara Lotfi, Rami Z. Morsi, Nada Zmeter, Mohammad W. Godah, Lina Alkhaled, Lara A. Kahale, Hala Nass, Hneine Brax, Racha Fadlallah and Elie A. Akl

    Citation: BMC Research Notes 2015 8:720

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  15. Content type: Research article

    Clinical practice guidelines need to be regularly updated with current literature in order to remain relevant. This paper reports on the approach taken by the Philippine Academy of Rehabilitation Medicine (PAR...

    Authors: Ephraim D. V. Gambito, Consuelo B. Gonzalez-Suarez, Karen A. Grimmer, Carolina M. Valdecañas, Janine Margarita R. Dizon, Ma. Eulalia J. Beredo and Marcelle Theresa G. Zamora

    Citation: BMC Research Notes 2015 8:643

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  16. Content type: Research article

    Systematic reviews (SRs) are widely recognized as the best means of synthesizing clinical research. However, traditional approaches can be costly and time-consuming and can be subject to selection and judgment...

    Authors: Cindy Crawford, Courtney Boyd, Shamini Jain, Raheleh Khorsan and Wayne Jonas

    Citation: BMC Research Notes 2015 8:631

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  17. Content type: Research article

    The aim of this paper is twofold: (1) to describe the fundamental differences between formative and reflective measurement models, and (2) to review the options proposed in the literature to obtain overall ins...

    Authors: Maria Laura Avila, Jennifer Stinson, Alex Kiss, Leonardo R. Brandão, Elizabeth Uleryk and Brian M. Feldman

    Citation: BMC Research Notes 2015 8:612

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  18. Content type: Research article

    It is important that scales exhibit strong measurement properties including those related to the investigation of issues that impact evidence-based practice. The validity of the Barriers to Research Utilization S...

    Authors: Brett Williams, Ted Brown and Shane Costello

    Citation: BMC Research Notes 2015 8:601

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  19. Content type: Research article

    Low response rates and inadequate question comprehension threaten the validity of survey results. We describe a simple procedure to implement personalized—as opposed to generically worded—questionnaires in the...

    Authors: Monica Taljaard, Shazia Hira Chaudhry, Jamie C. Brehaut, Charles Weijer and Jeremy M. Grimshaw

    Citation: BMC Research Notes 2015 8:574

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  20. Content type: Research article

    Interviewing is one of the main methods used for data collection in qualitative research. This paper explores the use of semi-structured interviews that were conducted by students with other students in a rese...

    Authors: Elaine Byrne, Ruairi Brugha, Eric Clarke, Aisling Lavelle and Alice McGarvey

    Citation: BMC Research Notes 2015 8:513

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  21. Content type: Research article

    Self-administered questionnaires provide a better alternative to disclose sensitive information in sexual health research. We describe the factors that determine the positive response (initial recruitment) to ...

    Authors: Lasantha S. Malavige, Pabasi Wijesekara, Dhanesha Seneviratne Epa, Priyanga Ranasinghe and Jonathan C. Levy

    Citation: BMC Research Notes 2015 8:410

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  22. Content type: Correspondence

    A priori sample size calculations are used to determine the adequate sample size to estimate the prevalence of the target population with good precision. However, published audits rarely report a priori calcul...

    Authors: Scott Weeks and Alvin Atlas

    Citation: BMC Research Notes 2015 8:282

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  23. Content type: Research article

    Electronic health records (EHRs) can provide valuable data for outcomes research. However, unlike administrative claims databases, EHRs lack eligibility tables or a standard way to define the benefit coverage ...

    Authors: Tzy-Chyi Yu and Huanxue Zhou

    Citation: BMC Research Notes 2015 8:229

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    The Erratum to this article has been published in BMC Research Notes 2015 8:340

  24. Content type: Research article

    Assessing methodological quality of primary studies is an essential component of systematic reviews. Following a systematic review which used a domain based system [United States Preventative Services Task For...

    Authors: Seán R O’Connor, Mark A Tully, Brigid Ryan, Judy M Bradley, George D Baxter and Suzanne M McDonough

    Citation: BMC Research Notes 2015 8:224

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  25. Content type: Short Report

    Research on the correlates of physical activity (PA) and sedentary behaviour (SB) to date has used independent prediction equations for each behaviour, without considering that they are both part of the same c...

    Authors: Nana Kwame Anokye and Emmanuel Stamatakis

    Citation: BMC Research Notes 2014 7:921

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  26. Content type: Research article

    A rigorous cross-cultural adaptation process of an existing instrument could be the best option for measuring health in different cultures, instead of developing a new tool, and prior to psychometric and valid...

    Authors: Anelise Daher, Judith Versloot and Luciane Rezende Costa

    Citation: BMC Research Notes 2014 7:897

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  27. Content type: Research article

    To ensure that clinical practice guidelines (CPGs) form a sound basis for decision-making in health care, it is necessary to be able to reliably assess and ensure their quality. This results in the need to ass...

    Authors: Michaela Eikermann, Nicole Holzmann, Ulrich Siering and Alric Rüther

    Citation: BMC Research Notes 2014 7:853

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  28. Content type: Research article

    Online focus groups (OFGs) are increasingly used as a method of data collection. Although their advantages for research have repeatedly been described, participants’ opinions about OFGs have seldom been studie...

    Authors: Marieke Zwaanswijk and Sandra van Dulmen

    Citation: BMC Research Notes 2014 7:756

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  29. Content type: Research article

    Patient reported outcome measures (PROMs) are used to evaluate lifestyle interventions but little is known about differences between patients returning valid and invalid responses, or of potential for bias in ...

    Authors: Judith A Cole, Paddy Gillespie, Susan M Smith, Molly Byrne, Andrew W Murphy and Margaret E Cupples

    Citation: BMC Research Notes 2014 7:725

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  30. Content type: Research article

    A randomized intervention study, “Preventive consultations for 20- to 40-year-old young adults”, investigated whether preventive consultations with a general practitioner could help young adults with multiple ...

    Authors: Elsebeth Hansen, Kirsten Fonager, Kirsten S Freund and Jørgen Lous

    Citation: BMC Research Notes 2014 7:632

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