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  1. DNA methylation contributes to the regulation of gene expression during development and cellular differentiation. The recently developed Methylated DNA ImmunoPrecipitation (MeDIP) assay allows a comprehensive ...

    Authors: Jinsong Jia, Aleksandra Pekowska, Sebastien Jaeger, Touati Benoukraf, Pierre Ferrier and Salvatore Spicuglia

    Citation: BMC Research Notes 2010 3:240

    Content type: Short Report

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  2. A large portion of tissues stored worldwide for diagnostic purposes is formalin-fixed and paraffin-embedded (FFPE). These FFPE-archived tissues are an extremely valuable source for retrospective (genetic) stud...

    Authors: Cornelis JJ Huijsmans, Jan Damen, Johannes C van der Linden, Paul HM Savelkoul and Mirjam HA Hermans

    Citation: BMC Research Notes 2010 3:239

    Content type: Technical Note

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  3. Falls management programmes have been instituted to attempt to reduce falls. This pilot study was undertaken to determine whether the Nintendo® WiiFit was a feasible and acceptable intervention in community-dwell...

    Authors: Marie A Williams, Roy L Soiza, Alison McE Jenkinson and Alison Stewart

    Citation: BMC Research Notes 2010 3:238

    Content type: Short Report

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  4. Major Histocompatibility Complex (MHC) has drawn the attention of evolutionary biologists due to its importance in crucial biological processes, such as sexual selection and immune response in jawed vertebrate...

    Authors: David Canal, Miguel Alcaide, Jarl A Anmarkrud and Jaime Potti

    Citation: BMC Research Notes 2010 3:236

    Content type: Technical Note

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  5. Chronic complications of diabetes can be reduced through optimal glycemic and lipid control as evaluated through measurement of glycosylated hemoglobin (A1C) and low-density lipoprotein cholesterol (LDL-C). We...

    Authors: Helena Klomp, Roland F Dyck, Nirmal Sidhu, Paul J Cascagnette and Gary F Teare

    Citation: BMC Research Notes 2010 3:233

    Content type: Short Report

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  6. The longitudinal epidemiology of major depressive episodes (MDE) is poorly characterized in most countries. Some potentially relevant data sources may be underutilized because they are not conducive to estimat...

    Authors: Scott B Patten

    Citation: BMC Research Notes 2010 3:231

    Content type: Project Note

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  7. Hematologic manifestations of the human immunodeficiency virus (HIV) infection are a well-recognized complication of the disease and may be clinically important. Our objective was to determine the risk factors...

    Authors: José A Mata-Marín, Jesús E Gaytán-Martínez, Rosa E Martínez-Martínez, Carla I Arroyo-Anduiza, José L Fuentes-Allen and Moisés Casarrubias-Ramirez

    Citation: BMC Research Notes 2010 3:230

    Content type: Short Report

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  8. Self-conscious emotions (shame, guilt and embarrassment) are part of many individuals' experiences of seeking STI testing. These emotions can have negative impacts on individuals' interpretations of the STI te...

    Authors: Myles Balfe, Ruairi Brugha, Diarmuid O' Donovan, Emer O' Connell and Deirdre Vaughan

    Citation: BMC Research Notes 2010 3:229

    Content type: Short Report

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  9. Studies from iodine-sufficient areas have shown that a high proportion of patients taking medication for thyroid diseases have thyroid stimulating hormone (TSH) levels outside the reference range. Next to pati...

    Authors: Anke Hannemann, Nele Friedrich, Robin Haring, Alexander Krebs, Henry Völzke, Dietrich Alte, Matthias Nauck, Thomas Kohlmann, Hans-Christof Schober, Wolfgang Hoffmann and Henri Wallaschofski

    Citation: BMC Research Notes 2010 3:227

    Content type: Short Report

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  10. MODELLER is a program for automated protein Homology Modeling. It is one of the most widely used tool for homology or comparative modeling of protein three-dimensional structures, but most users find it a bit ...

    Authors: Bhusan K Kuntal, Polamarasetty Aparoy and Pallu Reddanna

    Citation: BMC Research Notes 2010 3:226

    Content type: Technical Note

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  11. The Asteraceae represents an important plant family with respect to the numbers of species present in the wild and used by man. Nonetheless, genomic resources for Asteraceae species are relatively underdevelop...

    Authors: Lucy Gonthier, Arnaud Bellec, Christelle Blassiau, Elisa Prat, Nicolas Helmstetter, Caroline Rambaud, Brigitte Huss, Theo Hendriks, Hélène Bergès and Marie-Christine Quillet

    Citation: BMC Research Notes 2010 3:225

    Content type: Short Report

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  12. The innate immune system employs several receptor families that form the basis of sensing pathogen-associated molecular patterns. NOD (nucleotide-binding and oligomerization domain) like receptors (NLRs) compr...

    Authors: Marcel Kramer, Janne Boeck, Daniela Reichenbach, Christoph Kaether, Stefan Schreiber, Matthias Platzer, Philip Rosenstiel and Klaus Huse

    Citation: BMC Research Notes 2010 3:224

    Content type: Short Report

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  13. Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array CGH), which ...

    Authors: Stine H Kresse, Karoly Szuhai, Ana H Barragan-Polania, Halfdan Rydbeck, Anne-Marie Cleton-Jansen, Ola Myklebost and Leonardo A Meza-Zepeda

    Citation: BMC Research Notes 2010 3:223

    Content type: Technical Note

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  14. In animals mtDNA inheritance is maternal except in certain molluscan bivalve species which have a paternally inherited mitochondrial genome (genome M) along with the standard maternal one (genome F). Normally,...

    Authors: Eleni Kyriakou, Eleftherios Zouros and George C Rodakis

    Citation: BMC Research Notes 2010 3:222

    Content type: Short Report

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  15. The first objective of a DNA microarray experiment is typically to generate a list of genes or probes that are found to be differentially expressed or represented (in the case of comparative genomic hybridizat...

    Authors: Emma Laing and Colin P Smith

    Citation: BMC Research Notes 2010 3:221

    Content type: Technical Note

    Published on:

  16. α-Santalol, an active component of sandalwood oil, has shown chemopreventive effects on skin cancer in different murine models. However, effects of α-santalol on cell cycle have not been studied. Thus, the obj...

    Authors: Xiaoying Zhang, Wei Chen, Ruth Guillermo, Gudiseva Chandrasekher, Radhey S Kaushik, Alan Young, Hesham Fahmy and Chandradhar Dwivedi

    Citation: BMC Research Notes 2010 3:220

    Content type: Research article

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  17. The miR-200c/141 cluster has recently been implicated in the epithelial to mesenchymal transition (EMT) process. The expression of these two miRNAs is inversely correlated with tumorigenicity and invasiveness ...

    Authors: Rui Neves, Christina Scheel, Sandra Weinhold, Ellen Honisch, Katharina M Iwaniuk, Hans-Ingo Trompeter, Dieter Niederacher, Peter Wernet, Simeon Santourlidis and Markus Uhrberg

    Citation: BMC Research Notes 2010 3:219

    Content type: Short Report

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  18. Anthroposophic medicine is a physician-provided complementary therapy system involving counselling, artistic and physical therapies, and special medications. The purpose of this analysis was to identify predic...

    Authors: Harald J Hamre, Claudia M Witt, Gunver S Kienle, Anja Glockmann, Stefan N Willich and Helmut Kiene

    Citation: BMC Research Notes 2010 3:218

    Content type: Research article

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  19. Although altruism is a key principle in our current organ donation and transplantation system, the meanings and implications of the term have been widely debated. Recently, a new type of living organ donation-...

    Authors: Marie-Chantal Fortin, Marianne Dion-Labrie, Marie-Josée Hébert and Hubert Doucet

    Citation: BMC Research Notes 2010 3:216

    Content type: Short Report

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  20. Clock family genes encode transcription factors that regulate clock-controlled genes and thus regulate many physiological mechanisms/processes in a circadian fashion. Clock1 duplicates and copies of Clock3 and...

    Authors: Marion I Paibomesai, Hooman K Moghadam, Moira M Ferguson and Roy G Danzmann

    Citation: BMC Research Notes 2010 3:215

    Content type: Research article

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  21. SNP (Single Nucleotide Polymorphism) discovery is now routinely performed using high-throughput sequencing of reduced representation libraries. Our objective was to adapt 454 GS FLX based sequencing methodolog...

    Authors: Sophie Leroux, Katia Feve, Florence Vignoles, Olivier Bouchez, Christophe Klopp, Céline Noirot, David Gourichon, Sabine Richard, Christine Leterrier, Catherine Beaumont, Francis Minvielle, Alain Vignal and Frédérique Pitel

    Citation: BMC Research Notes 2010 3:214

    Content type: Technical Note

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  22. The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (...

    Authors: Annie Liu, Saraswathy Menon, Natalie J Colson, Sharon Quinlan, Hannah Cox, Madelyn Peterson, Thomas Tiang, Larisa M Haupt, Rod A Lea and Lyn R Griffiths

    Citation: BMC Research Notes 2010 3:213

    Content type: Short Report

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  23. Southern China is a major area for endemic nasopharyngeal carcinoma (NPC). Genetic factors as well as environmental factors play a role in development of NPC. To investigate the roles of previously described c...

    Authors: Xiuchan Guo, Yi Zeng, Hong Deng, Jian Liao, Yuming Zheng, Ji Li, Bailey Kessing and Stephen J O'Brien

    Citation: BMC Research Notes 2010 3:212

    Content type: Research article

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  24. The isolation of DNA-free RNA is a crucial step in the reverse transcription PCR (RT-PCR). Every RNA extraction procedure results in RNA samples contaminated with genomic DNA, which can cause false-positive ou...

    Authors: Lydia V Rump, Benedicta Asamoah and Narjol Gonzalez-Escalona

    Citation: BMC Research Notes 2010 3:211

    Content type: Technical Note

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  25. Epithelial cells are exposed to a variety of mechanical stimuli. Epithelial Na+ channels (ENaC) mediate sodium transport across apical membranes of epithelial cells that line the distal nephron, airway and alveol...

    Authors: Alexey V Karpushev, Daria V Ilatovskaya and Alexander Staruschenko

    Citation: BMC Research Notes 2010 3:210

    Content type: Short Report

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  26. Counselling on the danger signs of unpredictable obstetric complications and the appropriate management of such complications are crucial in reducing maternal mortality. The objectives of this study were to id...

    Authors: Malabika Sarker, Gerhard Schmid, Elin Larsson, Sylvia Kirenga, Manuela De Allegri, Florian Neuhann, Theodora Mbunda, Isaack Lekule and Olaf Müller

    Citation: BMC Research Notes 2010 3:209

    Content type: Short Report

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  27. Many studies have been done to find out the molecular mechanism of systemic acquired resistance (SAR) in plants in the past several decades. Numbers of researches have been carried out in the model plants such...

    Authors: Jiyu Zhang, Xiaoli Du, Qingju Wang, Xiukong Chen, Dong Lv, Kuanyong Xu, Shenchun Qu and Zhen Zhang

    Citation: BMC Research Notes 2010 3:208

    Content type: Short Report

    Published on:

  28. The aim of this study was to evaluate the safety and efficacy of outpatient laparoscopic cholecystectomy (OLC) in a day surgery unit in a teaching hospital. OLC was offered to patients with symptomatic choleli...

    Authors: Athanasios Marinis, Emmanouil Stamatakis, Athanasia Tsaroucha, Nikolaos Dafnios, Georgios Anastasopoulos, Georgios Polymeneas and Theodosios Theodosopoulos

    Citation: BMC Research Notes 2010 3:207

    Content type: Short Report

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  29. Long-term acute care hospitals (LTACs) provide specialized care for patients recovering from severe acute illness. In order to facilitate research into LTAC utilization and outcomes, we studied whether or not ...

    Authors: Jeremy M Kahn and Theodore J Iwashyna

    Citation: BMC Research Notes 2010 3:205

    Content type: Short Report

    Published on:

  30. The anabolic steroid, dehydroepiandosterone sulfate (DHEA-S), is secreted from the adrenal cortex. It plays a significant role in the body as a precursor to sex steroids as well as a lesser known role in the h...

    Authors: Courtney A Whetzel and Laura C Klein

    Citation: BMC Research Notes 2010 3:204

    Content type: Short Report

    Published on:

  31. General transcription factor (TFII-I) is a multi-functional transcription factor encoded by the Gtf2i gene, that has been demonstrated to regulate transcription of genes critical for development. Because of th...

    Authors: Iwona Fijalkowska, Deva Sharma, Carol J Bult and Sonye K Danoff

    Citation: BMC Research Notes 2010 3:203

    Content type: Short Report

    Published on:

  32. Propofol is a commonly used intravenous anesthetic agent, which produce rapid induction of and recovery from general anesthesia. Numerous clinical studies reported that propofol can potentially cause amnesia a...

    Authors: Srivatsan Kidambi, Joel Yarmush, Yevgeny Berdichevsky, Sangeetha Kamath, Wayne Fong and Joseph SchianodiCola

    Citation: BMC Research Notes 2010 3:201

    Content type: Short Report

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  33. Accurate prognosis is vital to the initiation of advance care planning particularly in a vulnerable, at risk population such as care home residents. The aim of this paper is to report on the revision and simpl...

    Authors: Davina Porock, Debra Parker-Oliver, Gregory F Petroski and Marilyn Rantz

    Citation: BMC Research Notes 2010 3:200

    Content type: Research article

    Published on:

  34. The advancements in DNA sequencing technologies have allowed researchers to progress from the analyses of a single organism towards the deep sequencing of a sample of organisms. With sufficient sequencing dept...

    Authors: Kelvin Li, Eli Venter, Shibu Yooseph, Timothy B Stockwell, Lance D Eckerle, Mark R Denison, David J Spiro and Barbara A Methé

    Citation: BMC Research Notes 2010 3:199

    Content type: Technical Note

    Published on:

  35. Chronic obstructive pulmonary disease (COPD) and asthma are considered underdiagnosed and misdiagnosed chronic diseases. In The Netherlands, a COPD-asthma telemedicine service has been developed to increase GP...

    Authors: Ioanna G Tsiligianni, Thys van der Molen, Nikolaos E Tzanakis, Nikolaos M Siafakas, Ellen van Heijst and Christos Lionis

    Citation: BMC Research Notes 2010 3:198

    Content type: Project Note

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  36. Apoptosis is a highly ordered and orchestrated multiphase process controlled by the numerous cellular and extra-cellular signals, which executes the programmed cell death via release of cytochrome c alterations i...

    Authors: Katarzyna Kokoszyńska, Leszek Rychlewski and Lucjan S Wyrwicz

    Citation: BMC Research Notes 2010 3:197

    Content type: Short Report

    Published on:

  37. About 130 million people are infected with the hepatitis C virus (HCV) worldwide, but effective treatment options are not yet available. One of the most promising targets for antiviral therapy is nonstructural...

    Authors: Paola JS Provazzi, Helen A Arcuri, Isabel Maria VG de Carvalho-Mello, João Renato R Pinho, Maurício L Nogueira, Mário S Palma and Paula Rahal

    Citation: BMC Research Notes 2010 3:196

    Content type: Short Report

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  38. The variability of maternal serum biochemical markers for Down syndrome, free β-hCG and PAPP-A can have a different impact on false-positive rates between the 10+0 and 13+6 week of gestation. The study populat...

    Authors: Dubravka Tišlarić-Medenjak, Ivana Zec, Ana-Maria Šimundić, Senka Sabolović-Rudman, Milan Kos and Željka Bukovec Megla

    Citation: BMC Research Notes 2010 3:194

    Content type: Short Report

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  39. Routine rapid testing for Bovine Spongiform Encephalopathy (BSE) has highlighted some problems with BSE rapid test performance, the most significant being the number of initially reactive samples and the false...

    Authors: Daniela Meloni, Katia Varello, Marzia Pezzolato, Elsa Manzardo, Maria C Cavarretta, Francesco Ingravalle, Maria Caramelli and Elena Bozzetta

    Citation: BMC Research Notes 2010 3:193

    Content type: Short Report

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  40. Numerous models, of variable quality, exist to impart the complex skills required to perform vascular anastomosis. These models differ with regard to the kinds of materials used, as well as their sizes, the ti...

    Authors: Philipe N Khalil, Axel Kleespies, Markus Rentsch, Wolfgang E Thasler, Karl-Walter Jauch and Christiane J Bruns

    Citation: BMC Research Notes 2010 3:189

    Content type: Short Report

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