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  1. Neuroimaging researchers have developed rigorous community data and metadata standards that encourage meta-analysis as a method for establishing robust and meaningful convergence of knowledge of human brain st...

    Authors: Angela R Laird, Simon B Eickhoff, P Mickle Fox, Angela M Uecker, Kimberly L Ray, Juan J Saenz Jr, D Reese McKay, Danilo Bzdok, Robert W Laird, Jennifer L Robinson, Jessica A Turner, Peter E Turkeltaub, Jack L Lancaster and Peter T Fox

    Citation: BMC Research Notes 2011 4:349

    Content type: Technical Note

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  2. The increasing prevalence of obesity is a significant health threat and a major public health challenge. A critical need exists to develop and evaluate practical methods for the treatment of obesity in the cli...

    Authors: Rebecca L Kesman, Jon O Ebbert, Katherine I Harris and Darrell R Schroeder

    Citation: BMC Research Notes 2011 4:346

    Content type: Short Report

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  3. Sandostatin® LAR® (Novartis Pharma AG) is a long-acting repeatable formulation of the somatostatin analogue octreotide, the safety and efficacy of which has been established through 15 years of clinical experienc...

    Authors: Holger Petersen, Jean-Claude Bizec, Helmut Schuetz and Marie-Laure Delporte

    Citation: BMC Research Notes 2011 4:344

    Content type: Short Report

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  4. Wild peanut species (Arachis spp.) are a rich source of new alleles for peanut improvement. Plant transcriptome analysis under specific experimental conditions helps the understanding of cellular processes relate...

    Authors: Carolina V Morgante, Patricia M Guimarães, Andressa CQ Martins, Ana CG Araújo, Soraya CM Leal-Bertioli, David J Bertioli and Ana CM Brasileiro

    Citation: BMC Research Notes 2011 4:339

    Content type: Research article

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  5. Nowadays, the sequencing of even the largest mammalian genomes has become a question of days with current next-generation sequencing methods. It comes as no surprise that dozens of genome assemblies are releas...

    Authors: Björn Hammesfahr, Florian Odronitz, Marcel Hellkamp and Martin Kollmar

    Citation: BMC Research Notes 2011 4:338

    Content type: Research article

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  6. This is a pilot cross sectional study using both quantitative and qualitative approach towards tutors teaching large classes in private universities in the Klang Valley (comprising Kuala Lumpur, its suburbs, a...

    Authors: Susan Thomas, Shamini Subramaniam, Mathew Abraham, LaySan Too and LooSee Beh

    Citation: BMC Research Notes 2011 4:337

    Content type: Short Report

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  7. Dengue fever is one of the most common tropical diseases worldwide. Early detection of the disease, followed by intravenous fluid therapy in patients with dengue hemorrhagic fever (DHF) or with warning signs o...

    Authors: Alexandre R Marra, Gustavo Faissol Janot de Matos, Renata Donato Janeri, Patricia Sousa Machado, Claudio Schvartsman and Oscar Fernando Pavão dos Santos

    Citation: BMC Research Notes 2011 4:335

    Content type: Project Note

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  8. In the treatment of clavicle fractures, the choice of procedure depends on the possibility of restoring the anatomical functional integrity of the shoulder.

    Authors: Silvana De Giorgi, Angela Notarnicola, Silvio Tafuri, Giuseppe Solarino, Lorenzo Moretti and Biagio Moretti

    Citation: BMC Research Notes 2011 4:333

    Content type: Research article

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  9. Nucleic acid amplification assays including PCR have revolutionized the detection of Mycobacterium tuberculosis (MTB). Tuberculosis spread to almost every organ of the body and is characterized on the basis of lo...

    Authors: Iram Amin, Muhammad Idrees, Zunaira Awan, Muhammad Shahid, Samia Afzal and Abrar Hussain

    Citation: BMC Research Notes 2011 4:332

    Content type: Short Report

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  10. In bioinformatics projects, scientific workflow systems are widely used to manage computational procedures. Full-featured workflow systems have been proposed to fulfil the demand for workflow management. Howev...

    Authors: Hiroyuki Mishima, Kensaku Sasaki, Masahiro Tanaka, Osamu Tatebe and Koh-ichiro Yoshiura

    Citation: BMC Research Notes 2011 4:331

    Content type: Technical Note

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  11. Euglenophyta and Chlorarachniophyta are groups of photosynthetic eukaryotes harboring secondary plastids of distinct green algal origins. Although previous phylogenetic analyses of genes encoding Calvin cycle ...

    Authors: Yi Yang, Shinichiro Maruyama, Hiroyuki Sekimoto, Hidetoshi Sakayama and Hisayoshi Nozaki

    Citation: BMC Research Notes 2011 4:330

    Content type: Research article

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  12. Ischemic stroke caused by infarction in the territory of the posterior cerebral artery (PCA) has not been studied as extensively as infarctions in other vascular territories. This single centre, retrospective ...

    Authors: Adrià Arboix, Guillermo Arbe, Luis García-Eroles, Montserrat Oliveres, Olga Parra and Joan Massons

    Citation: BMC Research Notes 2011 4:329

    Content type: Data Note

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  13. Areas for institutional improvement to enhance patient safety are commonly identified by surveying health care workers' (HCWs) attitudes, values, beliefs, perceptions and assumptions regarding institutional pr...

    Authors: Tita A Listyowardojo, Raoul E Nap and Addie Johnson

    Citation: BMC Research Notes 2011 4:328

    Content type: Short Report

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  14. Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.

    Authors: José L Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ana Pozueta, Miguel Calero, José L Dobato, Ana Frank-García, Fernando Valdivieso, José Berciano, Maria J Bullido and Onofre Combarros

    Citation: BMC Research Notes 2011 4:327

    Content type: Research article

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  15. There is limited data on Methicillin resistant Staphylococcus aureus (MRSA) in Uganda where, as in most low income countries, the routine use of chromogenic agar for MRSA detection is not affordable. We aimed to ...

    Authors: David P Kateete, Sylvia Namazzi, Moses Okee, Alfred Okeng, Hannington Baluku, Nathan L Musisi, Fred A Katabazi, Moses L Joloba, Robert Ssentongo and Florence C Najjuka

    Citation: BMC Research Notes 2011 4:326

    Content type: Research article

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  16. Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, n...

    Authors: Mohammad Tauqeer Alam, Eriko Takano and Rainer Breitling

    Citation: BMC Research Notes 2011 4:325

    Content type: Research article

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  17. Blood is a convenient sample and increasingly used for quantitative gene expression measurements with a variety of diseases including chronic fatigue syndrome (CFS). Quantitative gene expression measurements r...

    Authors: Virginia R Falkenberg, Toni Whistler, Janna' R Murray, Elizabeth R Unger and Mangalathu S Rajeevan

    Citation: BMC Research Notes 2011 4:324

    Content type: Short Report

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  18. Anderson-Fabry disease (FD) is caused by a deficit of the α-galactosidase A enzyme which leads to the accumulation of complex sphingolipids, especially globotriaosylceramide (Gb3), in all the cells of the body...

    Authors: Caterina Bono, Domenico Nuzzo, Giuseppe Albeggiani, Carmela Zizzo, Daniele Francofonte, Francesco Iemolo, Enzo Sanzaro and Giovanni Duro

    Citation: BMC Research Notes 2011 4:323

    Content type: Short Report

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  19. The current study was undertaken to determine the degree of activation of gallbladder mucosal mast cells, whether mast cell (MC) density or activation differ between patients with and without a positive clinic...

    Authors: Craig A Friesen, Nancy Neilan, James F Daniel, Kim Radford, Jennifer V Schurman, Ding-You Li, Linda Andre, Shawn D St Peter and George W Holcomb III

    Citation: BMC Research Notes 2011 4:322

    Content type: Research article

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  20. Cytochrome P450 enzymes (P450s) have been implicated in insecticide resistance. Anopheles minumus mosquito P450 isoforms CYP6AA3 and CYP6P7 are capable of metabolizing pyrethroid insecticides, however CYP6P8 lack...

    Authors: Panida Lertkiatmongkol, Ekachai Jenwitheesuk and Pornpimol Rongnoparut

    Citation: BMC Research Notes 2011 4:321

    Content type: Short Report

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  21. Heart failure is a critical condition that affects many people and often results from left ventricular dysfunction. Numerous studies investigating this condition have been performed using various model systems...

    Authors: Mallory K Tate, William S Lawrence, Randy L Gourley, Diana L Zavala, Lori E Weaver, Scott T Moen and Johnny W Peterson

    Citation: BMC Research Notes 2011 4:320

    Content type: Technical Note

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  22. Despite available guidelines on hypertension (HTN), use of antihypertensives is variable. This study was designed to ascertain frequency of patients on monotherapy and > 1 antihypertensive therapy and also to ...

    Authors: Aysha Almas, Salik ur Rehman Iqbal, Anabia Ehtamam and Aamir Hameed Khan

    Citation: BMC Research Notes 2011 4:318

    Content type: Research article

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  23. The hierarchical nature of medical education has been thought necessary for the safe care of patients. In this setting, medical students in particular have limited opportunities for experiential learning. We r...

    Authors: Ira L Leeds, Francis X Creighton, Matthew A Wheatley, Jana B Macleod, Jahnavi Srinivasan, Marie P Chery and Viraj A Master

    Citation: BMC Research Notes 2011 4:317

    Content type: Project Note

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  24. Pegylated (PEG)-interferon (IFN)-alfa-2a plus ribavirin (RBV) therapy for 24 weeks is now a standard treatment protocol for patients with hepatitis C virus (HCV) genotype 2. As RBV cannot be used in certain si...

    Authors: Reiko Etoh, Fumio Imazeki, Tomoko Kurihara, Kenichi Fukai, Keiichi Fujiwara, Makoto Arai, Tatsuo Kanda, Rintaro Mikata, Yutaka Yonemitsu and Osamu Yokosuka

    Citation: BMC Research Notes 2011 4:316

    Content type: Research article

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  25. To explore any gender-related differences in the prevalence of conditions-associated with non-alcoholic fatty liver disease (NAFLD) among Taiwanese taxi drivers in Taipei, Taiwan.

    Authors: Tao-Hsin Tung, Tsung-Hung Chang, Wei-Hsiu Chiu, Tzu-Han Lin, Hui-Chuan Shih, Ming-Huei Chang and Jorn-Hon Liu

    Citation: BMC Research Notes 2011 4:315

    Content type: Research article

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  26. The practice and research of medicine generates considerable quantities of data and model resources (DMRs). Although in principle biomedical resources are re-usable, in practice few can currently be shared. In...

    Authors: Bernard de Bono, Robert Hoehndorf, Sarala Wimalaratne, George Gkoutos and Pierre Grenon

    Citation: BMC Research Notes 2011 4:313

    Content type: Short Report

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  27. Organismal complexity is suggested to increase with the complexity of transcriptional and translational regulations. Supporting this notion is a recent study that demonstrated a higher level of tissue-specific...

    Authors: Chun-Hsi Chen, Hsuan-Yu Lin, Chia-Lin Pan and Feng-Chi Chen

    Citation: BMC Research Notes 2011 4:312

    Content type: Research article

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  28. Anaemia during pregnancy is major health problem. There is conflicting literature regarding the association between anaemia and its severity and maternal and perinatal outcomes.

    Authors: AbdelAziem A Ali, Duria A Rayis, Tajeldin M Abdallah, Mustafa I Elbashir and Ishag Adam

    Citation: BMC Research Notes 2011 4:311

    Content type: Research article

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  29. Snakes provide a unique vertebrate system for studying a diversity of extreme adaptations, including those related to development, metabolism, physiology, and venom. Despite their importance as research models...

    Authors: Todd A Castoe, Samuel E Fox, AP Jason de Koning, Alexander W Poole, Juan M Daza, Eric N Smith, Todd C Mockler, Stephen M Secor and David D Pollock

    Citation: BMC Research Notes 2011 4:310

    Content type: Research article

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  30. Cross-resistance to quinolones and beta-lactams is frequent in Enterobacteriaceae, due to the wide use of these antibiotics clinically and in the food industry. Prescription of one of these categories of antibiot...

    Authors: Thierry Frank, Jean R Mbecko, Pembe Misatou and Didier Monchy

    Citation: BMC Research Notes 2011 4:309

    Content type: Short Report

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  31. To preserve patient anonymity, health register data may be provided as binned data only. Here we consider as example, how to estimate mean survival time after a diagnosis of metastatic colorectal cancer from N...

    Authors: Henrik Støvring and Ivar S Kristiansen

    Citation: BMC Research Notes 2011 4:308

    Content type: Research article

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  32. Salmonella (S.) enterica is the main cause of salmonellosis in humans and animals. The epidemiology of this infection involves large geographical distances, and strains related to an episode of salmonellosis ther...

    Authors: Hélène van Cuyck, Alexandra Farbos-Granger, Philippe Leroy, Vuthy Yith, Bertrand Guillard, Jean Louis Sarthou, Jean Louis Koeck and Sun Lay Kruy

    Citation: BMC Research Notes 2011 4:306

    Content type: Research article

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  33. While the transcription of innate immunity genes in response to bacterial infection has been well-characterised in the Drosophila model, we recently demonstrated the capacity for such transcription to evolve i...

    Authors: Yixin H Ye and Elizabeth A McGraw

    Citation: BMC Research Notes 2011 4:305

    Content type: Short Report

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  34. To assist educators and researchers in improving the quality of medical research, we surveyed the editors and statistical reviewers of high-impact medical journals to ascertain the most frequent and critical s...

    Authors: Sara Fernandes-Taylor, Jenny K Hyun, Rachelle N Reeder and Alex HS Harris

    Citation: BMC Research Notes 2011 4:304

    Content type: Short Report

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  35. Apomixis, a natural form of asexual seed production in plants, is considered to have great biotechnological potential for agriculture. It has been hypothesised that de-regulation of the sexual developmental pa...

    Authors: Marco Pellino, Timothy F Sharbel, Martin Mau, Samuel Amiteye and José María Corral

    Citation: BMC Research Notes 2011 4:303

    Content type: Research article

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  36. The NAC transcription factor family is involved in the regulation of traits in both monocots and dicots of high agronomic importance. Understanding the precise functions of the NAC genes can be of utmost impor...

    Authors: Michael W Christiansen, Preben B Holm and Per L Gregersen

    Citation: BMC Research Notes 2011 4:302

    Content type: Research article

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  37. Body Mass Index (BMI), which is defined as the ratio between weight (in kg) and height (in m2), is often used in clinical practice as well as in large scale epidemiological studies to classify subjects as underwe...

    Authors: Bruno Federico, Filomena D'Aliesio, Fabio Pane, Giovanni Capelli and Angelo Rodio

    Citation: BMC Research Notes 2011 4:301

    Content type: Short Report

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  38. DNA methylation is a widespread epigenetic modification in vertebrate genomes. Genomic sites of DNA methylation can be bound by methyl-CpG-binding domain proteins (MBDs) and specific zinc finger proteins, whic...

    Authors: Ozren Bogdanović and Gert Jan C Veenstra

    Citation: BMC Research Notes 2011 4:300

    Content type: Technical Note

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  39. Dementia and cognitive impairment associated with aging are a major medical and social concern. Neuropsychological testing is a key element in the diagnostic procedures of Mild Cognitive Impairment (MCI), but ...

    Authors: João Maroco, Dina Silva, Ana Rodrigues, Manuela Guerreiro, Isabel Santana and Alexandre de Mendonça

    Citation: BMC Research Notes 2011 4:299

    Content type: Research article

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  40. Infertility is a major problem in sickle cell disease patients, especially in males. In addition to low serum testosterone, other abnormalities involving the accessory sex organs, such as the seminal vesicles ...

    Authors: Emmanuel K Abudu, Sulaiman A Akanmu, Oyetunji O Soriyan, Akinsegun A Akinbami, Adewumi Adediran, Titilope A Adeyemo and Charles C Okany

    Citation: BMC Research Notes 2011 4:298

    Content type: Research article

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  41. The use of the 2009 H1N1 vaccine has generated much debate concerning safety issues among the general population and physicians. It was questioned if this is a safe vaccine. Therefore, we investigated the safe...

    Authors: Harald Bias, David Quarcoo, Claus Meier-Wronski, Sabine Wicker, Joachim Seybold, Albert Nienhaus, David A Groneberg and Andres de Roux

    Citation: BMC Research Notes 2011 4:297

    Content type: Short Report

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  42. When detected, HIV can be effectively treated with antiretroviral therapy. Nevertheless in the U.S. approximately 25% of those who are HIV-infected do not know it. Much remains unknown about how to increase HI...

    Authors: D Keith McInnes, Jeffrey L Solomon, Barbara G Bokhour, Steven M Asch, David Ross, Kim M Nazi and Allen L Gifford

    Citation: BMC Research Notes 2011 4:295

    Content type: Short Report

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  43. CD99, a leukocyte surface glycoprotein, is broadly expressed in many cell types. On the cell surface, CD99 is expressed as two distinct isoforms, a long form and a short form. CD99 has been demonstrated to pla...

    Authors: Supansa Pata, Pavel Otáhal, Tomáš Brdička, Witida Laopajon, Kodchakorn Mahasongkram and Watchara Kasinrerk

    Citation: BMC Research Notes 2011 4:293

    Content type: Research article

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