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  1. Content type: Short Report

    Aging is marked by declines in levels of many sex hormones and growth factors, as well as in cognitive function. The P300 event-related potential has been established as a predictor of cognitive decline. We de...

    Authors: Eric R Braverman, Thomas JH Chen, Amanda LC Chen, Mallory M Kerner, Howard Tung, Roger L Waite, John Schoolfield and Kenneth Blum

    Citation: BMC Research Notes 2009 2:126

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  2. Content type: Short Report

    DNA watermarks can be applied to identify the unauthorized use of genetically modified organisms. It has been shown that coding regions can be used to encrypt information into living organisms by using the DNA...

    Authors: Dominik Heider, Martin Pyka and Angelika Barnekow

    Citation: BMC Research Notes 2009 2:125

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  3. Content type: Short Report

    Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases caused by novel infectious agents referred to as prions. Prions appear to be composed primarily, if not exclusiv...

    Authors: Christopher J Johnson, PUPA Gilbert, Debbie McKenzie, Joel A Pedersen and Judd M Aiken

    Citation: BMC Research Notes 2009 2:121

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  4. Content type: Technical Note

    Drought is one of the most important environmental factors causing water stress for cotton, and it greatly limits cotton growth and crop productivity. So far only a few drought-tolerance genes have been functi...

    Authors: Ling Zhang, Fu-Guang Li, Chuan-Liang Liu, Chao-Jun Zhang and Xue-Yan Zhang

    Citation: BMC Research Notes 2009 2:120

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  5. Content type: Short Report

    As the population ages and as surgical and anaesthetic techniques advance, more elderly people will be referred for surgery. Postoperative mortality and morbidity are certainly associated with increasing age; ...

    Authors: Irene Asouhidou, Theodora Asteri, Petros Sountoulides, Konstantinos Natsis and George Georgiadis

    Citation: BMC Research Notes 2009 2:118

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  6. Content type: Short Report

    Breast ductal endoscopy is a relatively new diagnostic method with ever growing importance in the work-up of patients with bloody nipple discharge. The ability to perform ductal endoscopy is very important and...

    Authors: Flora Zagouri, Theodoros N Sergentanis, Georgia Giannakopoulou, Effrosyni Panopoulou, Dimosthenis Chrysikos, Garifallia Bletsa, John Flessas, George Filippakis, Alexandros Papalabros, Kostas J Bramis and George C Zografos

    Citation: BMC Research Notes 2009 2:115

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  7. Content type: Short Report

    N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N''-4-pyridyl guanidine) (CHS 828) is the first candidate drug from a novel group of anti-tumour agents – the pyridyl cyanoguanidines, shown to be potent compounds interferin...

    Authors: Henrik Lövborg, Robert Burman and Joachim Gullbo

    Citation: BMC Research Notes 2009 2:114

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  8. Content type: Commentary

    The fabric of science is changing, driven by a revolution in digital technologies that facilitate the acquisition and communication of massive amounts of data. This is changing the nature of collaboration and ...

    Authors: Vincent S Smith

    Citation: BMC Research Notes 2009 2:113

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  9. Content type: Technical Note

    The development of reverse transcription – quantitative real-time PCR (RT-qPCR) platforms that can simultaneously measure the expression of multiple genes is dependent on robust assays that function under iden...

    Authors: Thomas Mikeska and Alexander Dobrovic

    Citation: BMC Research Notes 2009 2:112

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  10. Content type: Data Note

    Protein Post-Translational Modification (PTM) plays an essential role in cellular control mechanisms that adjust protein physical and chemical properties, folding, conformation, stability and activity, thus al...

    Authors: Tzong-Yi Lee, Justin Bo-Kai Hsu, Wen-Chi Chang, Ting-Yuan Wang, Po-Chiang Hsu and Hsien-Da Huang

    Citation: BMC Research Notes 2009 2:111

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  11. Content type: Short Report

    Diarrhoea is the second leading cause of illness and death in developing countries and the second commonest cause of death due to infectious diseases among children under five in such countries. Parasites, as ...

    Authors: Avik Kumar Mukherjee, Punam Chowdhury, Mihir Kumar Bhattacharya, Mrinmoy Ghosh, Krishnan Rajendran and Sandipan Ganguly

    Citation: BMC Research Notes 2009 2:110

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  12. Content type: Short Report

    Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several...

    Authors: Jinsheng Yu, Xiqiang Liu, Hui Ye and Xiaofeng Zhou

    Citation: BMC Research Notes 2009 2:109

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  13. Content type: Short Report

    Staphylococcus aureus is a major cause of food poisoning due to their ability to produce enterotoxins which if ingested in sufficient amounts results in sickness. Food handlers carrying enterotoxin-producing S. a...

    Authors: Edet E Udo, Siham Al-Mufti and M John Albert

    Citation: BMC Research Notes 2009 2:108

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  14. Content type: Short Report

    As FTA® cards provide an ideal medium for the field collection of DNA we sought to assess the quality of genomic DNA extracted from this source for use on the Illumina BovineSNP50 iSelect BeadChip which requires ...

    Authors: Matthew C McClure, Stephanie D McKay, Robert D Schnabel and Jeremy F Taylor

    Citation: BMC Research Notes 2009 2:107

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  15. Content type: Short Report

    Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more var...

    Authors: Nick T Peters, Anne Catherine Miller and Darryl L Kropf

    Citation: BMC Research Notes 2009 2:106

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  16. Content type: Technical Note

    Differential expression of perforin (PRF1), a gene with a pivotal role in immune surveillance, can be attributed to differential methylation of CpG sites in its promoter region. A reproducible method for quantita...

    Authors: Supraja Narasimhan, Virginia R Falkenberg, Maung M Khin and Mangalathu S Rajeevan

    Citation: BMC Research Notes 2009 2:104

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  17. Content type: Short Report

    The Clubfoot Assessment Protocol (CAP) was developed for follow-up of children treated for clubfoot. The objective of this study was to analyze reliability and validity of the six items used in the domain CAPM...

    Authors: Hanneke Andriesse, Gunnar Hägglund and Per-Erik Isberg

    Citation: BMC Research Notes 2009 2:103

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  18. Content type: Short Report

    The human cancer-related nucleoside triphosphatase (HCR-NTPase) is overexpressed in several tumour tissues including neuroblastoma. HCR-NTPase is an enzyme exhibiting a slow in vitro activity in hydrolysing nucle...

    Authors: Markus Pasdziernik, Barbara Kaltschmidt, Christian Kaltschmidt, Claudia Klinger and Michael Kaufmann

    Citation: BMC Research Notes 2009 2:102

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  19. Content type: Correspondence

    GenBank(R) is a public repository of all publicly available molecular sequence data from a range of sources. In addition to relevant metadata (e.g., sequence description, source organism and taxonomy), publica...

    Authors: Holly Miller, Catherine N Norton and Indra Neil Sarkar

    Citation: BMC Research Notes 2009 2:101

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  20. Content type: Short Report

    A phenotype of increased muscle mass (IMM) and reduced fat, comparable to reported effects of deleterious mutations in the myostatin gene (MSTN), has been observed in the Norwegian Spælsau breed. However, the gen...

    Authors: Inger A Boman and Dag I Våge

    Citation: BMC Research Notes 2009 2:98

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  21. Content type: Short Report

    Lower respiratory tract infections are a major cause of illness and death. Such infections are common in intensive care units (ICU) and their lethality persists despite advances in diagnosis, treatment and pre...

    Authors: Virgilio Bocanegra-García, María del Rayo Camacho-Corona, Mónica Ramírez-Cabrera, Gildardo Rivera and Elvira Garza-González

    Citation: BMC Research Notes 2009 2:95

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  22. Content type: Short Report

    Germline mutations in the BRCA2 gene have been suggested to account for about 5% of familial prostate cancer; mutations have been reported in 2% of early onset (i.e., ≤ 55 years) prostate cancer cases and a segre...

    Authors: Kristina Allen-Brady, James M Farnham, Nicola J Camp, Eric Karlins, Elaine A Ostrander and Lisa A Cannon-Albright

    Citation: BMC Research Notes 2009 2:94

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  23. Content type: Short Report

    In the past, rice genome served as a good model for studies involving comparative genomics of grass species. More recently, however, Brachypodium distachyon genome has emerged as a better model system for genomes...

    Authors: Sachin Kumar, Amita Mohan, Harindra S Balyan and Pushpendra K Gupta

    Citation: BMC Research Notes 2009 2:93

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  24. Content type: Technical Note

    There is a need for software scripts and modules for format parsing, data manipulation, statistical analysis and annotation especially for tasks related to marker identification from sequence data and sequence...

    Authors: B Jayashree, A BhanuPrakash, Anusha Jami, P Srinivasa Reddy, Spurthi Nayak and Rajeev K Varshney

    Citation: BMC Research Notes 2009 2:92

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  25. Content type: Short Report

    It has been demonstrated that extracellular mRNA can be detected in the circulation. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of breast cancer patie...

    Authors: Weizhu Zhu, Wenyi Qin, Ulus Atasoy and Edward R Sauter

    Citation: BMC Research Notes 2009 2:89

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  26. Content type: Short Report

    Within-species genome diversity has been best studied in humans. The international HapMap project has revealed a tremendous amount of single-nucleotide polymorphisms (SNPs) among humans, many of which show sig...

    Authors: Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura and Hiroshi Mitani

    Citation: BMC Research Notes 2009 2:88

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  27. Content type: Short Report

    Myosin II-dependent contraction of the cytokinetic ring and primary septum formation by chitin synthase II are interdependent processes during cytokinesis in Saccharomyces cerevisiae. Hence, null mutants of myosi...

    Authors: José F Rodríguez-Quiñones and José R Rodríguez-Medina

    Citation: BMC Research Notes 2009 2:87

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  28. Content type: Short Report

    From October 2006 to February 2007, clinical specimens from 452 patients with symptoms related to respiratory tract infection in the northern region of Taiwan were collected. Real-time PCR and direct immunoflu...

    Authors: Yuan-Ming Lee, Sheng-Fan Wang, Cheng-Ming Lee, Kuan-Hsuan Chen, Yu-Jiun Chan, Wu-Tse Liu and Yi-Ming Arthur Chen

    Citation: BMC Research Notes 2009 2:86

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  29. Content type: Short Report

    The murine ghrelin gene (Ghrl), originally sequenced from stomach tissue, contains five exons and a single transcription start site in a short, 19 bp first exon (exon 0). We recently isolated several novel first ...

    Authors: Inge Seim, Shea L Carter, Adrian C Herington and Lisa K Chopin

    Citation: BMC Research Notes 2009 2:85

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  30. Content type: Short Report

    The treatment of acute acromioclavicular (AC) joint injuries depends mainly on the type of the dislocation and patient demands. This study compares the mid term outcome of two frequently performed surgical con...

    Authors: Bernd A Leidel, Volker Braunstein, Susann Pilotto, Wolf Mutschler and Chlodwig Kirchhoff

    Citation: BMC Research Notes 2009 2:84

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  31. Content type: Short Report

    Women with rheumatoid arthritis (RA) have increased morbidity and mortality due to coronary heart disease. Chronic systemic inflammation is known to accelerate atherosclerosis and increase arterial stiffness i...

    Authors: Philip W Pemberton, Yasmeen Ahmad, Helena Bodill, Daniel Lokko, Samantha L Hider, Allen P Yates, Michael G Walker, Ian Laing and Ian N Bruce

    Citation: BMC Research Notes 2009 2:83

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  32. Content type: Technical Note

    We assessed NanoString's nCounter™ Analysis System for its ability to quantify gene expression of forty-eight genes in a single reaction with 100 ng of total RNA or an equivalent amount of tissue lysate. In th...

    Authors: Vladislav A Malkov, Kyle A Serikawa, Noel Balantac, James Watters, Gary Geiss, Afshin Mashadi-Hossein and Thomas Fare

    Citation: BMC Research Notes 2009 2:80

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  33. Content type: Short Report

    Marbling defined by the amount and distribution of intramuscular fat is an economically important trait of beef cattle in Japan. We have recently reported that single nucleotide polymorphisms (SNPs) in the endoth...

    Authors: Takahisa Yamada, Seiki Sasaki, Shin Sukegawa, Sachiyo Yoshioka, Youichi Takahagi, Mitsuo Morita, Hiroshi Murakami, Fumiki Morimatsu, Tatsuo Fujita, Takeshi Miyake and Yoshiyuki Sasaki

    Citation: BMC Research Notes 2009 2:78

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