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  1. Approximately 5-10% of persons infected with M. tuberculosis develop tuberculosis, but the factors associated with disease progression are incompletely understood. Both linkage and association studies have identi...

    Authors: Noffisat O Oki, Alison A Motsinger-Reif, Paulo RZ Antas, Shawn Levy, Steven M Holland and Timothy R Sterling

    Citation: BMC Research Notes 2011 4:28

    Content type: Short Report

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  2. Insulin resistance (IR) plays a major role in the pathogenesis of metabolic syndrome. Acanthosis nigricans (AN) is an easily detectable skin condition that is strongly associated with IR. The aims of this stud...

    Authors: Anuradha S Dassanayake, Anuradhani Kasturiratne, Madunil A Niriella, Udaya Kalubovila, Shaman Rajindrajith, Arjuna P de Silva, Norihiro Kato, A Rajitha Wickremasinghe and H Janaka de Silva

    Citation: BMC Research Notes 2011 4:25

    Content type: Short Report

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  3. Langerhans cells constitute a special subset of immature dendritic cells localized in the epidermis that play a key role in the skin's immune response. The production of cytokines is a key event in both the in...

    Authors: Simone R Campelo, Moises B da Silva, José LF Vieira, Jorge P da Silva and Claudio G Salgado

    Citation: BMC Research Notes 2011 4:24

    Content type: Short Report

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  4. To assess a pulmonary function change over time the mass flow sensor and the pneumotachograph are widely used in commercially available instruments. However, the smallest detectable change for both devices has...

    Authors: Herman Groepenhoff, Caroline B Terwee, Patrick MC Jak and Anton Vonk-Noordegraaf

    Citation: BMC Research Notes 2011 4:23

    Content type: Short Report

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  5. This article constitutes a partial update of the original systematic review evidence by Yengopal et al. from 15 January 2008 (published in the Journal of Oral Science in 2009) with primary focus on research qu...

    Authors: Steffen Mickenautsch and Veerasamy Yengopal

    Citation: BMC Research Notes 2011 4:22

    Content type: Correspondence

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  6. We developed a new version of the open source software package Peptrix that can yet compare large numbers of Orbitrap™ LC-MS data. The peptide profiling results for Peptrix on MS1 spectra were compared with th...

    Authors: Mark K Titulaer, Dominique de Costa, Christoph Stingl, Lennard J Dekker, Peter AE Sillevis Smitt and Theo M Luider

    Citation: BMC Research Notes 2011 4:21

    Content type: Technical Note

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  7. A recent analysis of protein sequences deposited in the NCBI RefSeq database indicates that ~8.5 million protein sequences are encoded in prokaryotic and eukaryotic genomes, where ~30% are explicitly annotated...

    Authors: Robert Powers, Jennifer C Copeland, Jaime L Stark, Adam Caprez, Ashu Guru and David Swanson

    Citation: BMC Research Notes 2011 4:17

    Content type: Technical Note

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  8. Injection of biomaterial to suburetral region, using minimally invasive procedure, has become an interesting topic for urologists to treat vesicoureteral reflux. The objective of this study was to evaluate the...

    Authors: Jalal Bakhtiari, Abdol Mohammad Kajbafzadeh, Mahdi Marjani, Abbas Veshkini, Azin Tavakoli, Mohammad Javad Gharagozlou and Amir Niasari-Naslaji

    Citation: BMC Research Notes 2011 4:14

    Content type: Short Report

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  9. The S. cerevisiae mating type switch model of double-strand break (DSB) repair, utilizing the HO endonuclease, is one of the best studied systems for both Homologous Recombination Repair (HRR) and direct ends-joi...

    Authors: Preeti Kanikarla-Marie, Sharon Ronald and Arrigo De Benedetti

    Citation: BMC Research Notes 2011 4:13

    Content type: Short Report

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  10. Targeting Induced Local Lesions in Genomes (TILLING) is a high throughput reverse genetics tool which detects mismatches (single point mutations or small indels) in large number of individuals of mutagenized p...

    Authors: Soni Gupta, Chaitanya Charakana, Yellamaraju Sreelakshmi and Rameshwar Sharma

    Citation: BMC Research Notes 2011 4:12

    Content type: Technical Note

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  11. In Dutch laboratories molecular detection of B. pertussis and B. parapertussis is commonly based on insertion sequences IS 481 and IS 1001, respectively. Both IS elements are more widely spread among Bordetella s...

    Authors: Lieuwe Roorda, Johannes Buitenwerf, Jacobus M Ossewaarde and Anneke van der Zee

    Citation: BMC Research Notes 2011 4:11

    Content type: Technical Note

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  12. Marbling defined by the amount and distribution of intramuscular fat, so-called Shimofuri, is an economically important trait of beef cattle in Japan. Our previous study detected 3 single nucleotide polymorphisms...

    Authors: Naoto Watanabe, Youichi Satoh, Tatsuo Fujita, Takeshi Ohta, Hiroyuki Kose, Youji Muramatsu, Takuji Yamamoto and Takahisa Yamada

    Citation: BMC Research Notes 2011 4:10

    Content type: Short Report

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  13. Primary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the cellular and molecular levels, necessary for novel drug development to treat highly prevalent dise...

    Authors: Jae-Seung Park, Sneha Surendran, Lisa M Kamendulis and Núria Morral

    Citation: BMC Research Notes 2011 4:8

    Content type: Short Report

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  14. This cross-sectional study was conducted during summer 2008 at an academic ophthalmic hospital to assess patient satisfaction with care services and examine the impact of different dimensions on overall satisf...

    Authors: Hossain Ziaei, Marzieh Katibeh, Armen Eskandari, Monir Mirzadeh, Zahra Rabbanikhah and Mohammad Ali Javadi

    Citation: BMC Research Notes 2011 4:7

    Content type: Short Report

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  15. The reticulon Nogo-B participates in cellular and immunological processes in murine macrophages. Since leukocytes are an essential part of the immune system in health and disease, we decided to investigate the...

    Authors: Kathrin Schanda, Martin Hermann, Nadia Stefanova, Viktoria Gredler, Christine Bandtlow and Markus Reindl

    Citation: BMC Research Notes 2011 4:6

    Content type: Short Report

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  16. The members of the genus Acinetobacter are Gram-negative cocobacilli that are frequently found in the environment but also in the hospital setting where they have been associated with outbreaks of nosocomial infe...

    Authors: Sara Martí, Jesús Rodríguez-Baño, Manuella Catel-Ferreira, Thierry Jouenne, Jordi Vila, Harald Seifert and Emmanuelle Dé

    Citation: BMC Research Notes 2011 4:5

    Content type: Short Report

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  17. The World Health Organization alert for the H1N1 influenza pandemic led to the implementation of certain measures regarding admission of patients with flu-like symptoms. All these instructions were adopted by ...

    Authors: Paul Zarogoulidis, Theodoros Constantinidis, Paschalis Steiropoulos, Nikolaos Papanas, Kostas Zarogoulidis and Efstratios Maltezos

    Citation: BMC Research Notes 2011 4:4

    Content type: Short Report

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  18. RNA quality and quantity are important factors for ensuring the accuracy of gene expression analysis and other RNA-based downstream applications. Extraction of high quality nucleic acids is difficult from neur...

    Authors: Lucélia Tavares, Paula M Alves, Ricardo B Ferreira and Claudia N Santos

    Citation: BMC Research Notes 2011 4:3

    Content type: Technical Note

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  19. Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointesti...

    Authors: Stephan W Reinhold, Albrecht Reichle, Sonja Leiminger, Tobias Bergler, Ute Hoffmann, Bernd Krüger, Bernhard Banas and Bernhard K Krämer

    Citation: BMC Research Notes 2011 4:2

    Content type: Research article

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  20. Molecular genetic studies on rare tumour entities, such as bone tumours, often require the use of decalcified, formalin-fixed, paraffin-embedded tissue (dFFPE) samples. Regardless of which decalcification proc...

    Authors: Danielle de Jong, Sofie LJ Verbeke, Danielle Meijer, Pancras CW Hogendoorn, Judith VMG Bovee and Károly Szuhai

    Citation: BMC Research Notes 2011 4:1

    Content type: Technical Note

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  21. The identification of copy number aberration in the human genome is an important area in cancer research. We develop a model for determining genomic copy numbers using high-density single nucleotide polymorphi...

    Authors: Beibei Guo, Alejandro Villagran, Marina Vannucci, Jian Wang, Caleb Davis, Tsz-Kwong Man, Ching Lau and Rudy Guerra

    Citation: BMC Research Notes 2010 3:350

    Content type: Research article

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  22. The maturing of gene expression microarray technology and interest in the use of microarray-based applications for clinical and diagnostic applications calls for quantitative measures of quality. This manuscri...

    Authors: Katrice A Lippa, David L Duewer, Marc L Salit, Laurence Game and Helen C Causton

    Citation: BMC Research Notes 2010 3:349

    Content type: Research article

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  23. Published data on the existence and magnitude of extended spectrum beta-lactamase (ESBL) production in urinary pathogens in local setting is limited. The aim of the present study was to determine the prevalenc...

    Authors: Sabrina J Moyo, Said Aboud, Mabula Kasubi, Eligius F Lyamuya and Samuel Y Maselle

    Citation: BMC Research Notes 2010 3:348

    Content type: Short Report

    Published on:

  24. Plasma microRNA (miRNA) has become a promising biomarker for detecting cancer; however, it remains uncertain whether miRNA expression levels in plasma reflect those in tumor cells. Our aim was to determine the...

    Authors: Junko H Ohyashiki, Tomohiro Umezu, Chiaki Kobayashi, Ryoko S Hamamura, Masami Tanaka, Masahiko Kuroda and Kazuma Ohyashiki

    Citation: BMC Research Notes 2010 3:347

    Content type: Research article

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  25. The Kafue lechwe (Kobus leche Kafuensis), a medium-sized semi-aquatic antelope, is endemic to the Kafue basin of Zambia. The population of the Kafue lechwe has significantly dropped in the last decades leading to...

    Authors: Musso Munyeme, Hetron M Munang'andu, John B Muma, Andrew M Nambota, Demelash Biffa and Victor M Siamudaala

    Citation: BMC Research Notes 2010 3:346

    Content type: Short Report

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  26. The occurrence of obstetric anal sphincter injuries (OASIS) - which may have serious, long-term effects on affected women, including faecal incontinence, despite primary repair - varies widely between countrie...

    Authors: Sari Räisänen, Katri Vehviläinen-Julkunen, Mika Gissler and Seppo Heinonen

    Citation: BMC Research Notes 2010 3:345

    Content type: Short Report

    Published on:

  27. Hydrophobins are a family of small secreted proteins with a characteristic pattern of eight cysteine residues found exclusively in filamentous fungi. They have originally been divided into two classes based on...

    Authors: Britt G Jensen, Mikael R Andersen, Mona H Pedersen, Jens C Frisvad and Ib Søndergaard

    Citation: BMC Research Notes 2010 3:344

    Content type: Short Report

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  28. Although many strain typing methods exist for pathogenic Escherichia coli, most have drawbacks in terms of resolving power, interpretability, or scalability. For this reason, multilocus sequence typing (MLST) is ...

    Authors: Swaraj Rajkhowa, Joy Scaria, Daniel L Garcia, Kimberlee A Musser, Bruce L Akey and Yung-Fu Chang

    Citation: BMC Research Notes 2010 3:343

    Content type: Correspondence

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  29. Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western population. Although genetic factors are considered to contribute to CLL etiology, at present genomic aberrations identified ...

    Authors: Yeong C Kim, Yong-Chul Jung, Jun Chen, Ali H Alhasan, Parawee Kaewsaard, Yanming Zhang, Shuo Ma, Steve Rosen and San Ming Wang

    Citation: BMC Research Notes 2010 3:341

    Content type: Short Report

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  30. Tuberculosis (TB) control is based on early detection and complete treatment of infectious cases. Consequently, it is important that TB suspects and patients can readily access medical care. This qualitative s...

    Authors: Raffael Ayé, Kaspar Wyss, Hanifa Abdualimova and Sadullo Saidaliev

    Citation: BMC Research Notes 2010 3:340

    Content type: Short Report

    Published on:

  31. Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susc...

    Authors: Deborah J Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R Morgan, Alan G Fraser, Linda C Tapsell and Lynnette R Ferguson

    Citation: BMC Research Notes 2010 3:339

    Content type: Short Report

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  32. Social capital may influence health and the patterns of association differ according its dimension such as cognitive, behavioral, bridging or bonding. There is a few numbers of studies in Latin America which c...

    Authors: Carolina M Borges, Ana Cristina V Campos, Andrea D Vargas, Efigênia F Ferreira and Ichiro Kawachi

    Citation: BMC Research Notes 2010 3:338

    Content type: Short Report

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  33. Exploration of DNA methylation and its impact on various regulatory mechanisms has become a very active field of research. Simultaneously there is an arising need for tools to process and analyse the data toge...

    Authors: Arie Zackay and Christine Steinhoff

    Citation: BMC Research Notes 2010 3:337

    Content type: Technical Note

    Published on:

  34. Many young people report they want to stop smoking and have tried to do so, but most of their quit attempts fail. For adult smokers, there is strong evidence that group behavioural support enhances quit rates....

    Authors: Wolfgang A Markham, Christopher Bridle, Gillian Grimshaw, Alan Stanton and Paul Aveyard

    Citation: BMC Research Notes 2010 3:336

    Content type: Project Note

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  35. The process of wound healing consists of several well distinguishable and finely tuned phases. For most of these phases specific proteins have been characterized, although the underlying mechanisms of regulati...

    Authors: Lars Steinsträßer, Frank Jacobsen, Tobias Hirsch, Marco Kesting, Caroline Chojnacki, Christoph Krisp and Dirk Wolters

    Citation: BMC Research Notes 2010 3:335

    Content type: Short Report

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  36. The Dahl salt-sensitive rat, but not the Dahl salt-resistant rat, develops hypertension and hypovitaminosis D when fed a high salt diet. Since the salt-sensitive rat and salt-resistant rat were bred from the S...

    Authors: Myrtle Thierry-Palmer, Teclemicael K Tewolde, Neremiah L Emmett and Mohamed A Bayorh

    Citation: BMC Research Notes 2010 3:332

    Content type: Short Report

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  37. Statistics on occupational accidents are based on data from registered employees. With the increasing number of immigrants employed illegally and/or without regular working visas in many developed countries, i...

    Authors: Giuseppe Mastrangelo, Ragnar Rylander, Alessandra Buja, Gianluca Marangi, Emanuela Fadda, Ugo Fedeli and Luca Cegolon

    Citation: BMC Research Notes 2010 3:331

    Content type: Short Report

    Published on:

  38. In nature, light is one of the most important environmental cues that fungi perceive and interpret. It is known not only to influence growth and conidiation, but also cellulase gene expression. We therefore st...

    Authors: Miklós Gyalai-Korpos, Gáspár Nagy, Zoltán Mareczky, André Schuster, Kati Réczey and Monika Schmoll

    Citation: BMC Research Notes 2010 3:330

    Content type: Short Report

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  39. Smoking is currently accepted as a well-established risk factor for many oral diseases such as oral cancer and periodontal disease. Provision of smoking cessation care to patients with oral problems is a respo...

    Authors: Atsushi Saito, Makiko Nishina, Keiko Murai, Akiko Mizuno, Fumie Ueshima, Takemi Makiishi and Tatsuya Ichinohe

    Citation: BMC Research Notes 2010 3:329

    Content type: Short Report

    Published on:

  40. Flow cytometry utilizes signals from fluorescent markers to separate targeted cell populations for gene expression studies. However, the stress of the FACS process could change normal gene expression profiles....

    Authors: Ismail Zaitoun, Christopher S Erickson, Kathy Schell and Miles L Epstein

    Citation: BMC Research Notes 2010 3:328

    Content type: Technical Note

    Published on:

  41. The increasing prevalence of obesity in young women is a major public health concern. Few data are available concerning the epidemiology of malnutrition especially obesity among pregnant women in the developin...

    Authors: Duria A Rayis, Ameer O Abbaker, Yasir Salih, Tayseer E Diab and Ishag Adam

    Citation: BMC Research Notes 2010 3:327

    Content type: Short Report

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