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  1. Cerebral malaria is the most severe neurological complication of falciparum malaria and a leading cause of death and neuro-disability in sub-Saharan Africa. This study aimed to describe functional deficits and...

    Authors: Richard Idro, Angelina Kakooza-Mwesige, Stephen Balyejjussa, Grace Mirembe, Christine Mugasha, Joshua Tugumisirize and Justus Byarugaba

    Citation: BMC Research Notes 2010 3:104

    Content type: Short Report

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  2. One of the main determinants of public immunization success is health professionals' support and recommendations. Little is known about the physicians' level of support and intentions regarding A(H1N1) pandemi...

    Authors: Eve Dubé, Vladimir Gilca, Chantal Sauvageau, Nicole Boulianne, François D Boucher, Julie A Bettinger, Shelly McNeil, Ian Gemmill, France Lavoie and Manale Ouakki

    Citation: BMC Research Notes 2010 3:102

    Content type: Short Report

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  3. Due to the limited number of species specific antibodies against fish proteins, differential gene expression analyses are vital for the study of host immune responses. Quantitative real-time reverse transcript...

    Authors: Andrea A Peña, Niels C Bols and Sergio H Marshall

    Citation: BMC Research Notes 2010 3:101

    Content type: Short Report

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  4. The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracr...

    Authors: Satyanarayana R Pondugula, Nithya N Raveendran and Daniel C Marcus

    Citation: BMC Research Notes 2010 3:100

    Content type: Short Report

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  5. The Charcot-Marie-Tooth (CMT) phenotype caused by mutation in the myelin protein zero (MPZ) gene varies considerably, from early onset and severe forms to late onset and milder forms. The mechanism is not well un...

    Authors: Geir J Braathen, Jette C Sand and Michael B Russell

    Citation: BMC Research Notes 2010 3:99

    Content type: Short Report

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  6. Human Papillomavirus (HPV) is considered as a necessary, but not sufficient, cause of cervical cancer. In this study, we aimed to assess the prevalence of HPV in a series of pre-malignant and malignant cervica...

    Authors: José V Fernandes, Rosely V Meissner, Maria GF Carvalho, Thales AAM Fernandes, Paulo RM Azevedo, João S Sobrinho, José CM Prado and Luisa L Villa

    Citation: BMC Research Notes 2010 3:96

    Content type: Short Report

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  7. Large phylogenies are crucial for many areas of biological research. One method of creating such large phylogenies is the supertree method, but creating supertrees containing thousands of taxa, and hence provi...

    Authors: Katie E Davis and Jon Hill

    Citation: BMC Research Notes 2010 3:95

    Content type: Technical Note

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  8. Due to its high sensitivity, the Smith-Waterman algorithm is widely used for biological database searches. Unfortunately, the quadratic time complexity of this algorithm makes it highly time-consuming. The exp...

    Authors: Yongchao Liu, Bertil Schmidt and Douglas L Maskell

    Citation: BMC Research Notes 2010 3:93

    Content type: Technical Note

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  9. Recently, the promise of a new universal long-term flu vaccine has become more tangible than ever before. Such a vaccine would protect against very many seasonal and pandemic flu strains for many years, making...

    Authors: Raffaele Vardavas, Romulus Breban and Sally Blower

    Citation: BMC Research Notes 2010 3:92

    Content type: Correspondence

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  10. Cryptosporidiosis and strongyloidiasis have been reported to be associated with HIV/AIDS. The present study was designed to determine the prevalence of Cryptosporidium and Strongyloides stercoralis infections amo...

    Authors: Amde Getaneh, Girmay Medhin and Techalew Shimelis

    Citation: BMC Research Notes 2010 3:90

    Content type: Short Report

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  11. Microarray data interpretation can be affected by sample RNA integrity. The ScreenTape Degradation Value (SDV) is a novel RNA integrity metric specific to the ScreenTape® platform (Lab901). To characterise the pe...

    Authors: Timothy M Wilkes, Alison S Devonshire, Stephen LR Ellison and Carole A Foy

    Citation: BMC Research Notes 2010 3:89

    Content type: Short Report

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  12. The Relative Codon Deoptimization Index (RCDI) was developed by Mueller et al. (2006) as measure of codon deoptimization by comparing how similar is the codon usage of a gene and the codon usage of a reference...

    Authors: Pere Puigbò, Lluís Aragonès and Santiago Garcia-Vallvé

    Citation: BMC Research Notes 2010 3:87

    Content type: Technical Note

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  13. The ubiquitin-based molecular switch dictating error free versus error prone repair has been conserved throughout eukaryotic evolution. A central component of this switch is the homotrimeric clamp PCNA, which ...

    Authors: Jan Brun, Roland K Chiu, Bradly G Wouters and Douglas A Gray

    Citation: BMC Research Notes 2010 3:85

    Content type: Short Report

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  14. Typically, electrodes for Deep Brain Stimulation (DBS) are used for chronic stimulation. However, there are conditions where this therapy has to be discontinued. In such cases using the DBS electrodes as a too...

    Authors: Thomas L Hauska, Hermann Lanmüller, Wolfgang Kainz and François Alesch

    Citation: BMC Research Notes 2010 3:84

    Content type: Short Report

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  15. Chronic diseases cause an ever-increasing percentage of morbidity and mortality, but many have modifiable risk factors. Many behaviors that predispose or protect an individual to chronic disease are interrelat...

    Authors: Federico Alonso, Carolyn O Walsh and Luis Salvador-Carulla

    Citation: BMC Research Notes 2010 3:83

    Content type: Project Note

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  16. Many breastfeeding women seek medical care from general practitioners (GPs) for various health problems and GPs may consider prescribing medicines in these consultations. Prescribing medicines to a breastfeedi...

    Authors: Hiranya S Jayawickrama, Lisa H Amir and Marie V Pirotta

    Citation: BMC Research Notes 2010 3:82

    Content type: Research article

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  17. Large scale microarray experiments are becoming increasingly routine, particularly those which track a number of different cell lines through time. This time-course information provides valuable insight into t...

    Authors: Colin S Gillespie, Guiyuan Lei, Richard J Boys, Amanda Greenall and Darren J Wilkinson

    Citation: BMC Research Notes 2010 3:81

    Content type: Short Report

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  18. microRNAs (miRNA) are short, endogenous transcripts that negatively regulate the expression of specific mRNA targets. The relative abundance of miRNAs is linked to function in vivo and miRNA expression patterns a...

    Authors: Sachin Sah, Matthew N McCall, Deepa Eveleigh, Michael Wilson and Rafael A Irizarry

    Citation: BMC Research Notes 2010 3:80

    Content type: Technical Note

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  19. Argininosuccinic aciduria (ASAuria) is an autosomal recessive disorder of the urea cycle relatively common in Saudi Arabia as a consequence of extensive consanguinity. It is the most common urea cycle disorder...

    Authors: Faiqa Imtiaz, Moeen Al-Sayed, Danyah Trabzuni, Bashair R Al-Mubarak, Osama Alsmadi, Mohamed S Rashed and Brian F Meyer

    Citation: BMC Research Notes 2010 3:79

    Content type: Short Report

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  20. Accurate nationally representative statistics on total and cause-specific mortality in Vietnam are lacking due to incomplete capture in government reporting systems. This paper presents total and cause-specifi...

    Authors: Anh D Ngo, Chalapati Rao, Nguyen Phuong Hoa, Timothy Adair and Nguyen Thi Kim Chuc

    Citation: BMC Research Notes 2010 3:78

    Content type: Technical Note

    Published on:

  21. The prevalence of cigarette smoking in Ukraine is different between genders and is among the highest in the world. There is need to identify gender-specific factors that are associated with having stopped smok...

    Authors: Alice Hazemba, Seter Siziya, Adamson S Muula and Emmanuel Rudatsikira

    Citation: BMC Research Notes 2010 3:76

    Content type: Short Report

    Published on:

  22. Transcriptome analysis during embryogenesis usually requires pooling of embryos to obtain sufficient RNA. Hence, the measured levels of gene-expression represent the average mRNA levels of pooled samples and t...

    Authors: Mark de Jong, Han Rauwerda, Oskar Bruning, Jurgo Verkooijen, Herman P Spaink and Timo M Breit

    Citation: BMC Research Notes 2010 3:73

    Content type: Technical Note

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  23. Detection of Tuberculosis agent like nontuberculous mycobacteria (NTM) species by culture and microscopic methods remains difficult and time consuming. A fast and reliable diagnosis of tuberculosis would great...

    Authors: Mochammad Hatta, Andi Rofian Sultan, Nataniel Tandirogang, Masjudi and Yadi

    Citation: BMC Research Notes 2010 3:72

    Content type: Technical Note

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  24. To evaluate whether the volume of blood suctioned during vacuum-assisted breast biopsy (VABB) is associated with hematoma formation and progression, patient's age and histology of the lesion.

    Authors: Flora Zagouri, Theodoros N Sergentanis, Philip Domeyer, Dimosthenis Chrysikos, Georgia Giannakopoulou, Nikolaos V Michalopoulos, Panagiotis Safioleas, Ioannis Flessas, Effrosyni Panopoulou, Garifallia Bletsa and George C Zografos

    Citation: BMC Research Notes 2010 3:70

    Content type: Short Report

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  25. In the last decade, the availability of gene sequences of many plant species, including tomato, has encouraged the development of strategies that do not rely on genetic transformation techniques (GMOs) for imp...

    Authors: Silvia Minoia, Angelo Petrozza, Olimpia D'Onofrio, Florence Piron, Giuseppina Mosca, Giovanni Sozio, Francesco Cellini, Abdelhafid Bendahmane and Filomena Carriero

    Citation: BMC Research Notes 2010 3:69

    Content type: Research article

    Published on:

  26. The permeabilization of mitochondrial membranes is a decisive event in apoptosis or necrosis culminating in cell death. One fundamental mechanism by which such permeabilization events occur is the calcium-induced...

    Authors: Sabine Eisenhofer, Ferenc Toókos, Burkhard A Hense, Sabine Schulz, Frank Filbir and Hans Zischka

    Citation: BMC Research Notes 2010 3:67

    Content type: Research article

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  27. Marbling, defined by the amount and the distribution of intramuscular fat and measured as beef marbling score (BMS), is an economically important trait of beef cattle in Japan. We recently reported that a sing...

    Authors: Shin Sukegawa, Takeshi Miyake, Yoichi Takahagi, Hiroshi Murakami, Fumiki Morimatsu, Takahisa Yamada and Yoshiyuki Sasaki

    Citation: BMC Research Notes 2010 3:66

    Content type: Short Report

    Published on:

  28. Less is known about the influence of hematocrit detection methodology on transfusion triggers. Therefore, the aim of the present study was to compare two different hematocrit-assessing methods. In a total of 5...

    Authors: Marco Bosshart, John F Stover, Reto Stocker, Lars M Asmis, Jörg Feige, Thomas A Neff, Reto A Schuepbach, Silvia R Cottini and Markus Béchir

    Citation: BMC Research Notes 2010 3:65

    Content type: Short Report

    Published on:

  29. In Trypanosoma brucei, the African trypanosome, endocytosis is developmentally regulated and substantially more active in all known mammalian infective stages. In both mammalian and insect stages endocytic activi...

    Authors: Senthil KA Natesan, Lori Peacock, Ka Fai Leung, Wendy Gibson and Mark C Field

    Citation: BMC Research Notes 2010 3:63

    Content type: Short Report

    Published on:

  30. microRNAs (miRNAs) are endogenous small non-coding RNAs that post-transcriptionally regulate gene expression. In plants, they typically show high complementarity to a single sequence motif within their target ...

    Authors: Sandra Niemeier, Leonardo Alves Junior and Thomas Merkle

    Citation: BMC Research Notes 2010 3:59

    Content type: Research article

    Published on:

  31. The chick chorio-allantoic membrane (CAM) assay is a commonly used method for studying angiogenic or anti-angiogenic activities in vivo. The ease of access allows direct monitoring of tumour growth by biomicrosco...

    Authors: Maurice Balke, Anna Neumann, Christian Kersting, Konstantin Agelopoulos, Carsten Gebert, Georg Gosheger, Horst Buerger and Martin Hagedorn

    Citation: BMC Research Notes 2010 3:58

    Content type: Short Report

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  32. Decomposition of concentration indices yields useful information regarding the relative importance of various determinants of inequitable health outcomes. But the two estimation approaches to decomposition in ...

    Authors: Vasoontara Yiengprugsawan, Lynette LY Lim, Gordon A Carmichael, Keith BG Dear and Adrian C Sleigh

    Citation: BMC Research Notes 2010 3:57

    Content type: Short Report

    Published on:

  33. The origin of adenocarcinomas presenting on the cervix uteri may be doubtful, i.e. whether it is of cervical or endometrial origin, due to the overlapping morphological features. In HPV negative samples, furth...

    Authors: Michael Odida, Belen Lloveras, Nuria Guimera and Elisabete Weiderpass

    Citation: BMC Research Notes 2010 3:54

    Content type: Short Report

    Published on:

  34. Presence of phosphorylated Serine biosynthesis pathway upstream to the de novo cysteine biosynthesis pathway makes PSAT a crucial enzyme. Besides this, phoshoserine produced by the enzyme can also be taken up ...

    Authors: Vibhor Mishra, Vahab Ali, Tomoyoshi Nozaki and Vinod Bhakuni

    Citation: BMC Research Notes 2010 3:52

    Content type: Short Report

    Published on:

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