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  1. Variance-stabilizing techniques have been used for some time in the analysis of gene expression microarray data. A new adaptation, the variance-stabilizing transformation (VST), has recently been developed to ...

    Authors: Mark J Dunning, Matthew E Ritchie, Nuno L Barbosa-Morais, Simon Tavaré and Andy G Lynch
    Citation: BMC Research Notes 2008 1:18
  2. The use of methods, both sensitive and specific, for rabies diagnosis are important tools for the control and prophylaxis of the disease. Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) has been used ...

    Authors: Danielle B Araújo, Helio Langoni, Marilene F Almeida and Jane Megid
    Citation: BMC Research Notes 2008 1:17
  3. Ultrastructural and biochemical abnormalities of mitochondria have been reported in skeletal muscle biopsies of CADASIL patients with mutations in the NOTCH3 nuclear gene. Additionally, it was proposed that NOTCH...

    Authors: Khaled K Abu-Amero, Ali Hellani and Saeed Bohlega
    Citation: BMC Research Notes 2008 1:16
  4. Hepatitis delta virus (HDV) is a satellite virus of hepatitis B. During viral replication the 1700-nucleotide-long genomic RNA and its complement, the antigenomic RNA, undergo self-cleavage catalyzed by intern...

    Authors: Larissa Savochkina, Victoria Alekseenkova, Tatyana Belyanko, Nadezhda Dobrynina and Robert Beabealashvilli
    Citation: BMC Research Notes 2008 1:15
  5. A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways in...

    Authors: Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Research Notes 2008 1:14
  6. The NORE1 protein was identified in a yeast two-hybrid screen as a Ras effector that binds Ras protein in a GTP-dependent manner. NORE1A is a growth and tumour suppressor that is inactivated in a variety of ca...

    Authors: Anna Moshnikova, Sergey Kuznetsov and Andrei V Khokhlatchev
    Citation: BMC Research Notes 2008 1:13
  7. The ability of Burkholderia pseudomallei to survive in water likely contributes to its environmental persistence in endemic regions. To determine the physiological adaptations which allow B. pseudomallei to survi...

    Authors: Richard A Moore, Apichai Tuanyok and Donald E Woods
    Citation: BMC Research Notes 2008 1:11
  8. Chronic diarrhoea is one of the most debilitating consequences of HIV infection in sub-Saharan Africa and it carries a high mortality rate. We report unexpectedly low concentrations of circulating aldosterone ...

    Authors: Trevor Kaile, Isaac Zulu, Ruth Lumayi, Neil Ashman and Paul Kelly
    Citation: BMC Research Notes 2008 1:10
  9. Public health emergencies heighten several challenges in risk-communication: providing trustworthy sources of information, reaching marginalized populations, and minimizing fear and public confusion. In emerge...

    Authors: Elena Savoia, Michael A Stoto, Paul D Biddinger, Paul Campbell, Kasisomayajula Viswanath and Howard Koh
    Citation: BMC Research Notes 2008 1:6
  10. The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strateg...

    Authors: Vicente Arnau, Miguel Gallach and Ignacio Marín
    Citation: BMC Research Notes 2008 1:5
  11. The Alternative Splicing Mutation Database (ASMD) presents a collection of all known mutations inside human exons which affect splicing enhancers and silencers and cause changes in the alternative splicing pat...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov
    Citation: BMC Research Notes 2008 1:4
  12. Some mutations in the internal regions of exons occur within splicing enhancers and silencers, influencing the pattern of alternative splicing in the corresponding genes. To understand how these sequence chang...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov
    Citation: BMC Research Notes 2008 1:3
  13. In Peru, cardiovascular disease was the second most common cause of death in those aged 65 years or more in 2000. Hypertension is a major modifiable risk factor for cardiovascular disease, and if treated can s...

    Authors: Alisha R Davies, J Jaime Miranda, Robert H Gilman and Liam Smeeth
    Citation: BMC Research Notes 2008 1:2

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