Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China

Table 3 Association of CYP2E1, GSTP1, MPO and NQO1 with risk of nasopharyngeal carcinoma (NPC) in an IgA+ population in southern China (Phase II cohort)

SNP-ID	Allele	SNP-Type	MAF†	Cases	Controls	OR	95%CI	Trend p
CYP2E1
rs3813867	C/G	Locus-region	0.219	207	226	1.34	0.97-1.86	0.08
rs2070673	A/T	Locus-region	0.450	212	229	0.95	0.73-1.24	0.69
GSTP1
rs7927381	C/T	~4k upstream	0.163	211	230	1.15	0.80-1.64	0.46
rs6591256	A/G	Locus-region	0.175	210	226	1.24	0.87-1.76	0.24
rs947895	A/C	Locus-region	0.182	208	226	0.98	0.69-1.38	0.89
MPO
rs2071409	A/C	intron	0.183	207	229	0.83	0.59-1.17	0.28
rs2243828	A/G	downstream	0.175	200	221	0.74	0.52-1.06	0.12
NQO1
rs10517	C/T	mRNA-UTR	0.296	210	224	0.83	0.62-1.11	0.21
rs1800566	C/T	Conding-nonsyn	0.474	205	225	0.90	0.69-1.18	0.46
rs4986998	C/T	intron	0.041	205	227	1.05	0.53-2.06	0.89
rs689452	C/G	intron	0.360	213	230	0.97	0.74-1.28	0.83
rs2917667	C/T	downstream	0.360	213	230	1.03	0.78-1.36	0.81
rs2917666	C/G	downstream	0.156	213	230	0.88	0.61-1.27	0.50
rs1469908	A/G	downstream	0.164	209	230	1.16	0.81-1.66	0.41

ISSN: 1756-0500