Radiation induced esophageal adenocarcinoma in a woman previously treated for breast cancer and renal cell carcinoma
© Raissouni et al.; licensee BioMed Central Ltd. 2012
Received: 16 April 2012
Accepted: 2 August 2012
Published: 9 August 2012
Secondary radiation-induced cancers are rare but well-documented as long-term side effects of radiation in large populations of breast cancer survivors. Multiple neoplasms are rare. We report a case of esophageal adenocarcinoma in a patient treated previously for breast cancer and clear cell carcinoma of the kidney.
A 56 year-old non smoking woman, with no alcohol intake and no familial history of cancer; followed in the National Institute of Oncology of Rabat Morocco since 1999 for breast carcinoma, presented on consultation on January 2011 with dysphagia. Breast cancer was treated with modified radical mastectomy, 6 courses of chemotherapy based on CMF regimen and radiotherapy to breast, inner mammary chain and to pelvis as castration. Less than a year later, a renal right mass was discovered incidentally. Enlarged nephrectomy realized and showed renal cell carcinoma. A local and metastatic breast cancer recurrence occurred in 2007. Patient had 2 lines of chemotherapy and 2 lines of hormonotherapy with Letrozole and Tamoxifen assuring a stable disease. On January 2011, the patient presented dysphagia. Oesogastric endoscopy showed middle esophagus stenosing mass. Biopsy revealed adenocarcinoma. No evidence of metastasis was noticed on computed tomography and breast disease was controlled. Palliative brachytherapy to esophagus was delivered. Patient presented dysphagia due to progressive disease 4 months later. Jejunostomy was proposed but the patient refused any treatment. She died on July 2011.
We present here a multiple neoplasm in a patient with no known family history of cancers. Esophageal carcinoma is most likely induced by radiation. However the presence of a third malignancy suggests the presence of genetic disorders.
KeywordsEsophageal cancer Radiation induced Breast cancer Renal cell carcinoma Multiple neoplasm
Esophageal cancer is the sixth most common malignancy worldwide with an estimated incidence of over than 300,000 new cases in 2011 . It is more frequent in males with a current male-to-female ratio estimated 7-10: 1 . Several meta-analyses have shown that tobacco and alcohol increase the risk of esophageal cancer especially the squamous cell histology [3, 4]. The role of radiation as a risk factor is not well established. Evidence from previous case reports and cohort studies raised the possibility of a relation between radiation therapy and esophageal cancer [5, 6]. There is a particular interest in the late side effects of radiation therapy for breast cancer because of the large number of women who receive such treatment each year . In a large multicenter retrospective series examining the risk of secondary non hematological malignancies in 376,825 breast cancer survivors, there were 3,301 patients with potentially radiotherapy-associated cancers, among them 343 patients presented esophageal carcinoma with a standardized incidence ratio (SIR) of 1.44 . Another large cohort of 220,806 women of the Surveillance, Epidemiology, and End Results (SEER) Program focusing on esophageal cancer after local breast cancer, diagnosed and treated between 1973 and 1993, showed that the SIR of esophageal cancer after radiation therapy was 54 percent higher than in the general population .
Second malignancies reported to be associated with renal cell carcinoma (antecedent, concurrent or subsequent) include bladder, prostate, rectal, and lung cancer as well as non-Hodgkin’s lymphoma and melanoma . Breast cancer also reported to be associated with renal cancer. In a series of 8,667 patients treated for renal cell carcinoma collected in the Swedish family database; 677 had a second primary malignancy with SIR of 1.55; there were 44 breast cancers with SIR 1.69. However, breast cancer was not associated with an increased risk of developing upper gastro-intestinal track carcinomas .
Second primary malignancies among cancer survivors account for 16% of all cancers. Few data currently exist regarding the molecular mechanisms for second primary cancers and other late outcomes after cancer treatment [11, 12].
This is a report of subsequent three malignancies, breast cancer, renal cell carcinoma and potentially radiation induced esophageal adenocarcinoma.
Experimental data has proven the role of radiation in developing esophageal carcinoma, induced by continuous gamma irradiation . Also based on data from the cohort of Japanese survivors of the atomic bombings of Hiroshima and Nagasaki, esophageal cancers have been conclusively related to ionizing radiation exposure . In human, the first case described was reported by Slaughter in 1957, 27 years of latency after radiation. It was of adenocarcinoma histological subtype . Since then case reports described mainly the squamous cell carcinoma subtype . In two previous large cohorts reporting data from the SEER, published in 1999 and 2006, there was an increased risk of developing esophageal cancer after breast cancer radiation [5, 17]. In the first report, the risk increased with time, reaching a standardized incidence ratio of 5.42 for esophageal squamous cell carcinoma 10 years after radiotherapy. A less definitive increasing trend was evident for esophageal adenocarcinoma; the relative risk after 10 years was 4.22 . In the second report, women treated with radical mastectomy and radiation had an estimated relative risks of 2.83 (95% confidence interval: 1.35, 5.92) and 2.17 (95% confidence interval: 1.67, 4.02) for squamous cell esophageal cancer at 5–9 and ≥10 years, respectively. No significant increase in risk was found for adenocarcinomas. In the same report esophageal carcinoma risk increases only for the upper (cervical) and middle (thoracic) third of the esophagus. In contrast, the risk for the lowest (abdominal) third of the esophagus was only not significantly increased . Similar data were obtained from Dutch and Scandinavian registry cohorts [8, 18].
Our patient presented adenocarcinoma of the middle esophagus. She fits some criteria of radiation induced cancers as previously described by Chudecki in early seventies, which are: history of previous irradiation, cancer occurring within the irradiated area and a long latent interval between irradiation and development of cancer that is over than 10 years in our case . However the presence of a third malignancy (renal cell carcinoma) concurrent to breast cancer could suggest the presence of genetic disorders predisposing to such late side effects of radiation.
There are several genetic syndrome associated with multiple neoplasms, such as BRCA mutation, Li-Fraumeni syndrome and Cowden disease . Syndrome-associated cancers usually develop at younger-than-usual ages, associated with a family history of developing metachronous tumors at high frequencies throughout life [20, 21]. However neither the clinical presentation of our patient, nor her familial histories are typical of one of those known syndromes.
Not all previously radiated patients or given chemotherapy experience second malignancies. Late effects of treatments may be modified by genetic penetrance, interaction between gene and environment and genes interactions .
Individual variations of pharmacodynamics and pharmacokinetics of drug metabolizing enzymes such as glutathione S-transferase, cytochrome P450s and thiopurine methyltrans-ferases, may influence the occurrence of therapy-related malignancies . In a series published by Relling and al, of children affected with leukemia and treated with prophylactic cerebral radiotherapy, children who had genetic defect of catabolism of thiopurine and high metabolism of thioguanine were more likely to present secondary brain tumors . Also there are few data supporting the role of polymorphism of DNA repair in cancer related treatments susceptibility . Other factors that may influence the occurrence of radiation related cancers are genomic instability, epigenetic phenomena and bystander effects . In our context we couldn’t realize genetic and pharmacogenic researches because they are not available. Some charred etiologic factors such as tobacco and alcohol intake are known to be associated with multiple cancers as lung, bladder, upper gastro-intestinal tract, breast, pancreas and kidney . Our patient hadn’t been exposed to such factors. Concerning the association of esophageal cancer with renal carcinoma, it was rarely reported. In a large cohort of 766 renal cell carcinomas, where 118 patients had second malignancies, only 3 had cancer of the upper gastro-intestinal tract . In other large series of the Mayo clinic in 2,722 patients with renal cell carcinoma, the papillary carcinoma histology was associated significantly with multiple neoplasms .
We report here a rare case of secondary esophageal carcinoma in a previously treated patient for breast cancer and renal cell carcinoma. The isolation of one causative factor leading to cancer is difficult. We suggest that esophageal carcinoma is more likely radiation induced. However the occurrence of three subsequent cancers suggest strongly the presence of genetic susceptibility. Careful patient selection, thorough treatment planning and modern radiation equipment could obviously reduce the dose to the surrounding tissues and thus decrease the incidence of secondary malignancies radiation induced in predisposed populations.
Written informed consent was obtained from the patient’s next of kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Jemal A, Bray F, Center MM, Ferlay J: Elizabeth Ward; David Forman. Global Cancer Statistics. CA CANCER J CLIN. 2011, 61: 69-90. 10.3322/caac.20107.PubMedView ArticleGoogle Scholar
- Rutegård M, Lagergren P, Nordenstedt H, Lagergren J: Oesophageal adenocarcinoma: the new epidemic in men. 2011, 69 (3): 244-248. Epub 2011 May 23Google Scholar
- Tramacere I, La Vecchia C, Negri E: Tobacco smoking and esophageal and gastric cardia adenocarcinoma: a meta-analysis. Epidemiology. 2011 May, 22 (3): 344-349. 10.1097/EDE.0b013e31821092cd.PubMedView ArticleGoogle Scholar
- Islami F, Fedirko V, Tramacere I, Bagnardi V, Jenab M, Scotti L, Rota M, Corrao G, Garavello W, Schüz J, Straif K, Negri E, Boffetta P, La Vecchia C: Alcohol drinking and esophageal squamous cell carcinoma with focus on light-drinkers and never-smokers: a systematic review and meta-analysis. Int J Cancer. 2011 Nov 15, 129 (10): 2473-84. 10.1002/ijc.25885.PubMedView ArticleGoogle Scholar
- Ahsan H, Neugut AI: Radiation therapy for breast cancer and increased risk for esophageal carcinoma. Ann Int Med. 1998, 128: 114-117.PubMedView ArticleGoogle Scholar
- Levi F, Randimbison L, Te V-C, La Vecchia C: Increased risk of esophageal cancer after breast cancer. Annals of Oncology. 2005, 16: 1829-1831. 10.1093/annonc/mdi363.PubMedView ArticleGoogle Scholar
- Curtis RE, Boice JD, Stovall M, et al: Leukemia risk following radiotherapy for breast cancer. J Clin Oncol. 1989, 7: 21-29.PubMedGoogle Scholar
- Linda Morris B, Chen BE, Pfeiffer RM: Risk of second non-hematological malignancies among 376,825 breast cancer survivors. Breast Cancer Res Treat. 2007, 106: 439-451. 10.1007/s10549-007-9509-8.View ArticleGoogle Scholar
- Houston Thompson R: Bradley C. Leibovich, John C. Cheville, W. Scott Webster, Christine M. Lohse, Eugene D. Kwon, Horst Zincke* and Michael L. Blute. Second Primary Malignancies Associated With Renal Cell Carcinoma Histological Subtypes. The journal of urology. September 2006, 176: 900-904. 10.1016/j.juro.2006.04.080.PubMedView ArticleGoogle Scholar
- Hao L: Kari Hemminki and Jan Sundquist. Renal Cell Carcinoma as First and Second Primary Cancer: Etiological Clues From the Swedish Family-Cancer Database. The Journal Of Urology. 2011, 185: 2045-2049. 10.1016/j.juro.2011.02.001.View ArticleGoogle Scholar
- Travis LB, Rabkin CS: Linda Morris Brown, James M. Allan and al. Cancer Survivorship Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations. J Natl Cancer Inst. 2006, 98: 15-25. 10.1093/jnci/djj001.PubMedView ArticleGoogle Scholar
- Travis LB: The Epidemiology of Second Primary Cancers. Cancer Epidemiol Biomarkers Prev. 2006, 15: 2020-2026. 10.1158/1055-9965.EPI-06-0414.PubMedView ArticleGoogle Scholar
- Warren S, Gates O: Radiation-induced experimental cancer of the esophagus. Am] PathoI. 1968, 53: 667-679.Google Scholar
- Pierce DA, Shimizu Y, Preston DL, et al: Studies of the mortality of atomic bomb survivors. Report 12, part I. Cancer: 1950–1990. Radiat Res. 1996, 146: 1-27. 10.2307/3579391.PubMedView ArticleGoogle Scholar
- Slaughter DP, Southwick HW: Mucosal carcinomas as a result of irradiation. Arch Surg. 1957, 74: 420-429. 10.1001/archsurg.1957.01280090118015.View ArticleGoogle Scholar
- Oliver M, Ulrich S, Marco Glashorster F-J: Prott and Normann Willich. Radiation-Induced Esophageal Carcinoma 30 Years after Mediastinal Irradiation: Case Report and Review of the Literature. Jpn J Clin OncoI. 1999, 29 (3): 164-170. 10.1093/jjco/29.3.164.View ArticleGoogle Scholar
- Zablotska LB, Chak A, Das A, Neugut AI: Increased Risk of Squamous Cell Esophageal Cancer after Adjuvant Radiation Therapy for Primary Breast Cancer. American Journal of Epidemiology. 2005, 161: 330-337. 10.1093/aje/kwi050.PubMedView ArticleGoogle Scholar
- Michael Schaapveld, Otto Visser, Marieke J. Louwman, Elisabeth G.E. de Vries, Pax H.B, Willemse, Rene´e Otter, Winette T.A. van der Graaf, Jan-Willem W. Coebergh, and Flora E. van Leeuwen: A Dutch Population-Based Study. J Clin Oncol. 26: 1239-1246.
- Chudecki B: Radiation cancer of the thoracic oesophagus. Br] Radiol. 1972, 45: 303-304. 10.1259/0007-1285-45-532-303.View ArticleGoogle Scholar
- Hisada M, Garber JE, Fung CY, Fraumeni JF, Li FP: Multiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst. 1998, 90: 606-611. 10.1093/jnci/90.8.606.PubMedView ArticleGoogle Scholar
- Kalow W, Ozdemir V, Tang BK, Tothfalusi L, Endrenyi L: The science of pharmacological variability: an essay. Clin Pharmacol Ther. 1999, 66: 445-447. 10.1016/S0009-9236(99)70006-8.PubMedView ArticleGoogle Scholar
- Evans WE, Relling MV: Moving towards individualized medicine with pharmacogenomics. Nature. 2004, 429: 464-468. 10.1038/nature02626.PubMedView ArticleGoogle Scholar
- Felix CA: Chemotherapy-related second cancers. Multiple primary cancers. Edited by: Neugut AI, Meadows AT, Robinson E. 1999, Lippincott Williams & Wilkins, Philadelphia (PA), 137-164.Google Scholar
- Relling MV, Rubnitz JE, Rivera GK, Boyett JM, Hancock ML, Felix CA, et al: High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet. 1999, 354: 34-39. 10.1016/S0140-6736(98)11079-6.PubMedView ArticleGoogle Scholar
- Allan JM, Smith AG, Wheatley K, Hills RK, Travis LB, Hill DA, et al: Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy. Blood. 2004, 104: 3872-3877. 10.1182/blood-2004-06-2161.PubMedView ArticleGoogle Scholar
- Morgan WF, Day JP, Kaplan MI, McGhee EM, Limoli CL: Genomic instability induced by ionizing radiation. Radiat Res. 1996, 146: 247-258. 10.2307/3579454.PubMedView ArticleGoogle Scholar
- farhang rabbani, victor e. reuter, jared katz, and paul russo: Second primary malignancies associated with renal cell carcinoma: influence of histologic type. Urology. 2000, 56 (3):Google Scholar
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