Retroperitoneal solitary fibrous tumor of the pelvis with pollakiuria: a case report
© Tsushimi et al.; licensee BioMed Central Ltd. 2012
Received: 18 September 2012
Accepted: 19 October 2012
Published: 29 October 2012
Solitary fibrous tumor (SFT) is rare soft tissue tumor, and it occurs most commonly in the pleura. Retroperitoneal SFT is generally found by palpable mass or abdominal distention. Here we report a case of SFT presenting pollakiuria.
A 64-year-old man was referred to our hospital for pollakiuria. Contrasted-enhanced computed tomography revealed a heterogeneously enhanced pelvic tumor of approximately 10 × 8 × 7 cm. Invasion of the surrounding organs, distal metastasis, and lymph node swelling were absent. Therefore, surgical resection was performed. The resected specimen was a 13 × 8 × 5.5-cm encapsulated elastic hard tumor weighing 420 g. Histologically, the tumor consisted of oval or spindle cells growing in a random manner in a collagenous matrix. Immunohistochemically, the specimen was positive for CD34, bcl-2, as well as vimentin and negative for c-kit. On the basis of these findings, a retroperitoneal solitary fibrous tumor (SFT) of the pelvis was diagnosed.
Surgery is the primary treatment for SFT, and pathologically negative margins are important for good prognosis.
KeywordsPelvis Solitary fibrous tumor Pollakiuria
Solitary fibrous tumor (SFT) is rare soft tissue tumor initially reported by Klemperer et al.. It occurs most commonly in the pleura; however, extrathoracic SFT has also been reported[2–4]. Several cases of retroperitoneal soft tissue pelvic tumor have been reported. SFT can be diagnosed preoperatively only by needle biopsy because it is a rare lesion and not easily recognizable. In addition, no specific tumor markers have been identified or images published for this tumor type. We report a case of retroperitoneal SFT of the pelvis in a patient with pollakiuria. In this report, a review of related literature is also provided.
SFT is a soft tissue tumor first identified in the pleura by Klempler et al. in 1931. It is most common in the pleura, as demonstrated by Gold et al., who reported that 54 of 79 cases of SFT (68%) were found in the pleura. SFT also arises in the retroperitoneal region, as in our case, and has been reported in the eye socket and intracranial region. Retroperitoneal SFT is usually diagnosed by the presence of an abdominal distention or a palpable mass. Pollakiuria has been associated with SFT, as in our case, and it can also be related to difficulty with urination.
Pathological analysis of SFT showed poorly differentiated atypical tumor cells arranged in a random manner in hyalinized collagen fibers (patternless pattern) or in a hemangiopericytoma-like growth pattern. Characteristic immunohistochemical findings of SFT include high positivity for CD34, which is known as the fibroblast-related antigen. Positive results of immunohistochemical testing for bcl-2 and vimentin and negative results for c-kit are also helpful in the diagnosis of SFT[10, 11]. The tumor in this case demonstrated these characteristics of SFT.
The first-line treatment for SFT is surgical resection. Negative margins and complete surgical resection are essential for good prognosis. Complete image inspection should be performed to determine the extent of tumor invasion around the organs as well as to ensure complete surgical resection and preservation of organ function. In this case, MRI was not possible because a pacemaker had been implanted previously. However, CE-CT revealed absence of tumor invasion of other organs, lymph node swelling and distal metastasis. Therefore complete resection was performed.
The World Health Organization classification of soft tissue tumor in 2002 categorized extrapleural SFT as a fibroblastic/myofibroblastic tumor of intermediate malignancy, which is defined as an ubiquitous mesenchymal tumor of possible fibroblastic type with a prominent hemangiopericytoma-like branching vascular pattern. Pathological characteristics of malignant SFT include hypercellular lesions, cytological atypia, numerous mitoses (4 or more mitoses per 10 high-power fields), tumor necrosis, and/or infiltrating margins[7, 10–12]. Vallat-Decouvelaere et al. reported malignancy in 8 of 92 cases of extrathoracic SFT, including local recurrence or distal metastasis, in 7 of which at least one of the typical pathological characteristics was observed in the primary tumor.
Various benign or malignant soft tissue tumors emerging from fat, muscle, and nerve may develop in the retroperitoneal region. Some retroperitoneal tumors are diagnosed because of clinical symptoms or image inspections. However, a definite diagnosis is difficult to reach in many cases. Preoperative needle biopsy has been reportedly useful in diagnosis of SFT. However, this technique carries the risk of peritoneal dissemination. Needle biopsy may be considered when complete surgical resection is not possible because some retroperitoneal tumors, including malignant lymphoma and malignant paraganglioma, may be sensitive to chemotherapy.
Takazawa et al. reported no recurrence in patients with SFT positive for both CD34 and bcl-2. Other researchers reported a correlation between expression of p53 and poor prognosis[6, 14]. Yokoi et al. also found an association between expression of p53 in malignant SFT and poor prognosis, recurrence, nuclear atypia, high mitotic activity, and local invasion compared with that in benign SFT. They suggested a possible association between p53 mutation and benign to malignant transformation in SFT. Therefore, expression of CD34, bcl-2, and p53 may be important in predicting the prognosis of patients with SFT.
Complete surgical resection is the standard therapy for SFT and pathologically negative margins are important to achieve a good prognosis. Postoperative histochemical analysis revealed no CD34, bcl-2, or p53 expression after complete resection, and no atypical cells in the surgical margins, suggesting good prognosis in our case. However, careful follow-up is necessary, since recurrence has been reported more than 10 years after surgery in retroperitoneal SFT.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Klemperer P, Rabin CB: Primary neoplasm of the pleura: a report of five cases. Arch Pathol. 1931, 11: 385-412.Google Scholar
- Gomi K, Shimada K, Kajikawa S, Yazawa K, Shirota H, Nakamura T: A case of solitary fibrous tumor located in the retroperitoneum (in Japanese with English abstract). J Jpn Surg Assoc. 2009, 70: 2833-2838. 10.3919/jjsa.70.2833.View ArticleGoogle Scholar
- Dorfman DM, To K, Dickersin GR, Rosenberg AE, Pilch BZ: Solitary fibrous tumor of the orbit. Am J Surg Pathol. 1994, 18: 281-287. 10.1097/00000478-199403000-00008.PubMedView ArticleGoogle Scholar
- Wang C, Manucha V, Faro S, Weaver M, Mukherjee AL: Fourth ventricular solitary fibrous tumor: a case report and review of the literature. J Med Case Rep. 2012, 17 (6): 205-View ArticleGoogle Scholar
- Tambo M, Fujimoto K, Miyake M, Hoshiyama F, Matsushita C, Hirao Y: Clinicopathological review of 46 primary retroperitoneal tumors. Int J Urol. 2007, 14: 785-8. 10.1111/j.1442-2042.2007.01839.x.PubMedView ArticleGoogle Scholar
- Schirosi L, Lantuejoul S, Cavazza A, Murer B, Yves Brichon P, Migaldi M, Sartori G, Sgambato A, Rossi G: Pleuro-pulmonary solitary fibrous tumors: a clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR. Am J Surg Pathol. 2008, 32: 1627-1642. 10.1097/PAS.0b013e31817a8a89.PubMedView ArticleGoogle Scholar
- Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF, Coit DG: Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002, 94: 1057-1068. 10.1002/cncr.10328.PubMedView ArticleGoogle Scholar
- Kubota Y, Kawai N, Tozawa K, Hayashi Y, Sasaki S, Kohri K: Solitary fibrous tumor of the peritoneum found in the prevesical space. Urol Int. 2000, 65: 53-56. 10.1159/000064836.PubMedView ArticleGoogle Scholar
- Sano T, Nishiyama H, Kanematsu A, Takahashi T, Nakamura E, Kamoto T, Mikami Y, Koyama T, Ogawa O: Solitary fibrous tumor in the pelvic space: a case report. Hinyokika Kiyo. 2007, 53: 897-901.PubMedGoogle Scholar
- Fletcher CDM, Unni K, Meryens F: World Health Organization classification of tumors, pathology and genetics, tumors of soft tissue and bone. 2002, Lyon: IARC Press, 86-88.Google Scholar
- England DM, Hochholzer L, McCarthy MJ: Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 1989, 13: 640-658. 10.1097/00000478-198908000-00003.PubMedView ArticleGoogle Scholar
- Vallat-Decouvelaere AV, Dry SM, Fletcher CD: Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoratic tumors. Am J Surg Pathol. 1998, 22: 1501-1511. 10.1097/00000478-199812000-00007.PubMedView ArticleGoogle Scholar
- Takizawa I, Saito T, Kitamura Y, Arai K, Kawaguchi M, Takahashi K, Hara N: Primary solitary fibrous tumor (SFT) in the retroperitoneum. Urol Oncol. 2008, 26: 254-259. 10.1016/j.urolonc.2007.03.024.PubMedView ArticleGoogle Scholar
- Yokoi T, Tsuzuki T, Yatabe Y, Suzuki M, Kurumaya H, Koshikawa T, Kuhara H, Kuroda M, Nakamura N, Nakatani Y, Kakudo K: Solitary fibrous tumor: significance of p53 and CD34 immunoreactivity in its malignant transformation. Histopathology. 1998, 32: 423-432. 10.1046/j.1365-2559.1998.00412.x.PubMedView ArticleGoogle Scholar
- Yoshida R, Takada H, Iwamoto S, Uedono Y, Kawanishi H, Yoshioka K, Nakane Y, Hioki K, Sakaida N, Okamura A: A solitary fibrous tumor in the perianal region with a 13-year follow-up: report of a case. Surg Today. 1999, 29: 642-645. 10.1007/BF02482992.PubMedView ArticleGoogle Scholar