| |
Hepatic steatosis
|
Hepatic steatosis
|
p value
|
|---|
| |
Yes
|
No
| |
|---|
| |
n = 35
|
n = 25
| |
|---|
|
Age at biopsy (yrs)
|
39.0 ± 8.9
|
40.0 ± 7.2
|
ns
|
|
Age at HIV diagnosis (yrs)
|
32.9 ± 8.9
|
34.0 ± 6.8
|
ns
|
|
Male
|
32 (91%)
|
22 (88%)
|
ns
|
|
ethnicity
|
14 (40%)
|
9 (36%)
|
ns
|
|
Weight (kg)
|
74.2 ± 9.2
|
69.7 ± 10.8
|
0.74
|
|
Weight > 75 kg
|
17 (48%)
|
7 (28%)
|
ns
|
|
Diabetes mellitus
|
2 (6%)
|
1 (4%)
|
ns
|
|
Alcohol
|
11 (31%)
|
7 (28%)
|
ns
|
|
Antiretroviral therapy
| | | |
|
No therapy
|
10 (28%)
|
7 (28%)
|
ns
|
|
NRTI
|
7 (20%)
|
3 (12%)
|
ns
|
|
Duration (mths)
|
22.3 ± 18.8
|
21.7 ± 12.4
|
ns
|
|
HAART only
|
9 (26%)
|
13 (52%)
|
0.037
|
|
Duration (mths)
|
30.4 ± 27.3
|
29.5 ± 27.1
|
ns
|
|
Sequential
|
9 (26%)
|
2 (8%)
|
0.08
|
|
Duration (mths)
|
92.8 ± 37.2
|
106.0
|
ns
|
|
Received PI
|
13 (37%)
|
8 (32%)
|
ns
|
|
Received NNRTI
|
14 (40%)
|
10 (40%)
|
ns
|
|
Received stavudine
|
12 (34%)
|
5 (20%)
|
ns
|
|
Received didanosine
|
8 (23%)
|
5 (20%)
|
ns
|
|
Received zidovudine
|
21 (60%)
|
12 (48%)
|
ns
|
|
Time from HIV diagnosis to HAART (mths)
|
47.4 + 38.7
|
40.4 + 50.9
|
ns
|
|
CD4 count (/mm3)
|
410 (110–1100)
|
490 (100–1200)
|
ns
|
|
HIV VL (copies/ml)
|
UD (UD-210955)
|
70 (UD-121843)
|
ns
|
|
HCV VL (IU/ml)
|
441309 (2716–769231)
|
1286755 (29451–14975540)
|
ns
|
|
Non 1 genotype
|
6/21 (28%)
|
6/21 (28%)
|
ns
|
|
Cholestrol
|
4.3 ± 1.2
|
4.1 ± 1.08
|
ns
|
|
HDL
|
1.1 ± 0.5
|
1.1 ± 0.3
|
ns
|
|
Triglyceride
|
2.2 ± 2.0
|
1.5 ± 0.6
|
ns
|
|
Cholestrol/HDL ratio
|
4.8 ± 2.2
|
3.8 ± 1.0
|
ns
|
|
Fasting blood glucose
|
6.1 + 6.4
|
5.1 ± 0.9
|
ns
|
|
ALT (IU/L)
|
131 + 149.8
|
104 ± 74.6
|
ns
|
|
Fibrosis stage
|
3.0 ± 1.9
|
2.5 ± 1.7
|
ns
|
|
NI grade
|
3.7 ± 1.9
|
3.7 + 1.7
|
ns
|
|
Cirrhosis
|
12 (34%)
|
3 (12%)
|
0.049
|
- Normal range for lab values: ALT <40 iu/L, Bilirubin <17 umol/L, Alkaline phosphates 30–130 iu/L, Albumin 35–41 g/L, Cholestrol <5 mmol/L, triglycerides <2.30 mmol/L, HDL cholesterol >1.00 mmol/L, Cholestrol/HDL <5.00 mmol/L, fasting blood glucose 3–5.5 mmol/L
- HDL: high density lipoprotein
- UD: undetectable
- Data on lipids unavailable in 10 patients
