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Following a call from the UK House of Commons Science and Technology Committee for evidence on reproducibility and research integrity, and the roles different institutions play in this, we partnered with the UK Reproducibility Network to provide a platform to share feedback on the topic with the wider scientific community. 
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BMC Research Notes is an open access journal publishing peer-reviewed contributions from across all scientific and clinical disciplines, including intriguing initial observations, updates to previous work and established methods, valid negative results, and scientific data sets and descriptions. We are committed to making it easier to find, cite and share your short reports by providing an inclusive forum for valuable data and research observations.

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© Kallayanee

Editor's choice collection: qPCR - Applications and methodologies

This retrospective collection edited by Dr. Diego A. Forero, MD, PhD (Fundación Universitaria del Área Andina, Colombia) showcases advances to the methodology and application of quantitative polymerase chain reactions (qPCRs), which are being used by researchers and healthcare providers around the world. 

Please explore selected articles on the topic published in BMC Research Notes. 

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  1. The mangrove cricket, Apteronemobius asahinai, shows endogenous activity rhythms that synchronize with the tidal cycle (i.e., a free-running rhythm with a period of ~ 12.4 h [the circatidal rhythm]). Little is kn...

    Authors: Aya Satoh, Miwako Takasu, Kentaro Yano and Yohey Terai

    Citation: BMC Research Notes 2021 14:387

    Content type: Data note

    Published on:

  3. Induction of labour (IOL), or starting labour artificially, can be a lifesaving intervention for pregnant women and their babies, and rates are rising significantly globally. As rates increase, it becomes incr...

    Authors: Shuchita Mundle, Hillary Bracken, Vaishali Khedikar, Jayashree Mulik, Brian Faragher, Thomas Easterling, Simon Leigh, Paul Granby, Alan Haycox, Mark A. Turner, Kate Lightly, Miroslava Ebringer, Zarko Alfirevic, Beverly Winikoff and Andrew D. Weeks

    Citation: BMC Research Notes 2021 14:355

    Content type: Data note

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  4. Existing information on Arctic marine food web structure is fragmented. Integrating data across research programs is an important strategy for building a baseline understanding of food web structure and functi...

    Authors: Ashley Ehrman, Carie Hoover, Carolina Giraldo, Shannon A. MacPhee, Jasmine Brewster, Christine Michel, James D. Reist, Michael Power, Heidi Swanson, Andrea Niemi, Wojciech Walkusz and Lisa Loseto

    Citation: BMC Research Notes 2021 14:347

    Content type: Data note

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  5. The incidence of ductal carcinoma in situ (DCIS) is increasing due to more widespread mammographic screening. DCIS, the earliest form of breast cancer, is non-invasive at the time of detection. If DCIS tissues...

    Authors: Tomoo Jikuzono, Eriko Manabe, Shoko Kure, Haruki Akasu, Tomoko Ishikawa, Yoko Fujiwara, Masujiro Makita and Osamu Ishibashi

    Citation: BMC Research Notes 2021 14:340

    Content type: Data note

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  6. This data article aims to introduce the “XPolaris” R-package, designed to facilitate access to detailed soil data at any geographical location within the contiguous United States (CONUS). Without the need of a...

    Authors: Luiz H. Moro Rosso, Andre F. de Borja Reis, Adrian A. Correndo and Ignacio A. Ciampitti

    Citation: BMC Research Notes 2021 14:327

    Content type: Data note

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  7. Haemaphysalis longicornis is the most important tick species in Japan and has a wide range of vector capacity. Due to its veterinary and medical importance, this tick species has been used as a model for tick/vec...

    Authors: Rika Umemiya-Shirafuji, Jinlin Zhou, Min Liao, Badgar Battsetseg, Damdinsuren Boldbaatar, Takeshi Hatta, Thasaneeya Kuboki, Takeshi Sakaguchi, Huey Shy Chee, Takeharu Miyoshi, Xiaohong Huang, Naotoshi Tsuji, Xuenan Xuan and Kozo Fujisaki

    Citation: BMC Research Notes 2021 14:326

    Content type: Data note

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  8. Trueperella pyogenes has been considered a major causative agent of metritis, abortion, and death in a broad range of domestic and wild animals, including cattle, swine, sheep, goats, camels, buffalo, deer, antel...

    Authors: Iradj Ashrafi Tamai, Abdolmajid Mohammadzadeh, Arash Ghalyanchi Langeroudi, Pezhman Mahmoodi, Zahra Ziafati Kafi, Babak Pakbin and Taghi Zahraei Salehi

    Citation: BMC Research Notes 2021 14:323

    Content type: Data note

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  9. Reported rainfall data from multiple rain gauges and its corresponding estimate from Dual-Polarization (Dual-Pol) radar is presented here. The ordered set of data pairs were collected from multiple peer review...

    Authors: Tyson H. Walsh, Jesse W. Lansford, T. V. Hromadka II and Prasada Rao

    Citation: BMC Research Notes 2021 14:319

    Content type: Data note

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  10. Patients with thalassemia major (TM) have the highest mortality rate due to heart failure induced by myocardial iron overload. However, T2* weighted MR imaging is currently a gold standard approach for measuri...

    Authors: Emad Shiae Ali, Mohamad Amin Bakhshali, Seyed Jafar Shoja Razavi, Hoorak Poorzand and Parvaneh Layegh

    Citation: BMC Research Notes 2021 14:318

    Content type: Data note

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  12. Complex algae are photosynthetic organisms resulting from eukaryote-to-eukaryote endosymbiotic-like interactions. Yet the specific lineages and mechanisms are still under debate. That is why large scale phylog...

    Authors: Mick Van Vlierberghe, Arnaud Di Franco, Hervé Philippe and Denis Baurain

    Citation: BMC Research Notes 2021 14:306

    Content type: Data note

    Published on:

  13. Navigation is the most important feature of homing pigeons, however no integrated response to genetic mechanism of navigation has been reported. The generated data herein represent whole-genome resequencing da...

    Authors: Ali Esmailizadeh, Hamed Kharrati-Koopaee and Hojjat Assadoullahpour Nanaei

    Citation: BMC Research Notes 2021 14:305

    Content type: Data note

    Published on:

  14. In March 2020, Iran tackled the first national wave of COVID-19 that was particularly felt in Mashhad, Iran’s second-most populous city. Accordingly, we performed a spatio-temporal study in this city to invest...

    Authors: Shahab MohammadEbrahimi, Alireza Mohammadi, Robert Bergquist, Mahsan Akbarian, Mahnaz Arian, Elahe Pishgar and Behzad Kiani

    Citation: BMC Research Notes 2021 14:292

    Content type: Data note

    Published on:

  16. Four-dimensional flow CMR allows for a comprehensive assessment of the blood flow kinetic energy of the ventricles of the heart. In comparison to standard two-dimensional image acquisition, 4D flow CMR is felt...

    Authors: Ciaran Grafton-Clarke, Saul Crandon, Jos J. M. Westenberg, Peter P. Swoboda, John P. Greenwood, Rob J. van der Geest, Andrew J. Swift, Vassilios S. Vassiliou, Sven Plein and Pankaj Garg

    Citation: BMC Research Notes 2021 14:289

    Content type: Data note

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  17. Sulfation is an essential physiological process that regulates the function of a wide array of molecules involved in brain development. We have previously shown expression levels for the sulfate transporter Slc13...

    Authors: Tracey J. Harvey, Raul Ayala Davila, Diana Vidovic, Sazia Sharmin, Michael Piper and David G. Simmons

    Citation: BMC Research Notes 2021 14:269

    Content type: Data note

    Published on:

  18. The “Integrating a neonatal healthcare package for Malawi” (IMCHA#108030) project conducted mixed-methods to understand facility-based implementation factors for newborn health innovations in low-resourced hea...

    Authors: Mai-Lei Woo Kinshella, Alinane Linda Nyondo-Mipando, Queen Dube, David M. Goldfarb and Kondwani Kawaza

    Citation: BMC Research Notes 2021 14:267

    Content type: Data note

    Published on:

  19. Sengon (Falcataria moluccana) is a popular tree species in community plantation forests in Java, Indonesia due to its fast-growing and multipurpose characteristics. However, without effective control measures sen...

    Authors: Ulfah J. Siregar, Aditya Nugroho, Hasyyati Shabrina, Fitri Indriani, Apriliya Damayanti and Deden D. Matra

    Citation: BMC Research Notes 2021 14:261

    Content type: Data note

    Published on:

  21. Arachnids have fascinating and unique biology, particularly for questions on sex differences and behavior, creating the potential for development of powerful emerging models in this group. Recent advances in g...

    Authors: Daniel Stribling, Peter L. Chang, Justin E. Dalton, Christopher A. Conow, Malcolm Rosenthal, Eileen Hebets, Rita M. Graze and Michelle N. Arbeitman

    Citation: BMC Research Notes 2021 14:236

    Content type: Data note

    Published on:

  23. We employed the Illumina NGS platform to sequence genomes of 4 different strains of the pathogenic oomycete Pythium insidiosum, the causative agent of pythiosis. These strains were isolated from humans in Thailan...

    Authors: Theerapong Krajaejun, Weerayuth Kittichotirat, Preecha Patumcharoenpol, Thidarat Rujirawat, Tassanee Lohnoo and Wanta Yingyong

    Citation: BMC Research Notes 2021 14:197

    Content type: Data note

    Published on:

  24. Pearl millet (Pennisetum glaucum) is a staple cereal crop for semi-arid regions. Its whole genome sequence and deduced putative gene sequences are available. However, the functions of many pearl millet genes are ...

    Authors: Daisuke Tsugama and Tetsuo Takano

    Citation: BMC Research Notes 2021 14:181

    Content type: Data note

    Published on:

  25. The ongoing Coronavirus disease 2019 (COVID-19) pandemic has drastically impacted the global health and economy. Computed tomography (CT) is the prime imaging modality for diagnosis of lung infections in COVID...

    Authors: Shokouh Shakouri, Mohammad Amin Bakhshali, Parvaneh Layegh, Behzad Kiani, Farid Masoumi, Saeedeh Ataei Nakhaei and Sayyed Mostafa Mostafavi

    Citation: BMC Research Notes 2021 14:178

    Content type: Data note

    Published on:

  26. Dall’s sheep (Ovis dalli dalli) are important herbivores in the mountainous ecosystems of northwestern North America, and recent declines in some populations have sparked concern. Our aim was to improve capabilit...

    Authors: Kelly E. Williams, Damian M. Menning, Eric J. Wald, Sandra L. Talbot, Kumi L. Rattenbury and Laura R. Prugh

    Citation: BMC Research Notes 2021 14:173

    Content type: Data note

    Published on:

  27. The impact of the current COVID-19 pandemic has been felt worldwide. Many vulnerable populations rely heavily on peer support provided by individual or collaborative groups. This study aimed to evaluate the im...

    Authors: Julie McMullan, Ashleen L. Crowe, Caitlin Bailie and Amy Jayne McKnight

    Citation: BMC Research Notes 2021 14:168

    Content type: Data note

    Published on:

  28. Tree legume species play an important role in forest restoration in the tropics. Understanding how different species adjust carbohydrate allocation and growth under distinct nutrient availability will enhance ...

    Authors: Roberto K. Jaquetti and José Francisco C. Gonçalves

    Citation: BMC Research Notes 2021 14:153

    Content type: Data note

    Published on:

  29. Identifying orthology relationships among sequences is essential to understand evolution, diversity of life and ancestry among organisms. To build alignments of orthologous sequences, phylogenomic pipelines of...

    Authors: Mick Van Vlierberghe, Hervé Philippe and Denis Baurain

    Citation: BMC Research Notes 2021 14:143

    Content type: Data note

    Published on:

  31. Agarwood is the aromatic heartwood formed upon wounding of Aquilaria trees either naturally formed due to physical wound sustained from natural phenomena followed by microbial infection, or artificially induced u...

    Authors: Farah Adibah Abdul Kadir, Kamalrul Azlan Azizan and Roohaida Othman

    Citation: BMC Research Notes 2021 14:117

    Content type: Data note

    Published on:

  33. Gastric cancer (GC) is a multifactorial disease and the fifth most frequent diagnosed cancer worldwide. It accounts for one third of cancer-related mortalities. Geospatial analysis using geographical informati...

    Authors: Fatemeh Hashemi Amin, Mahtab Ghaemi, Sayyed Mostafa Mostafavi, Ladan Goshayeshi, Khadijeh Rezaei, Mehdi Vahed and Behzad Kiani

    Citation: BMC Research Notes 2021 14:91

    Content type: Data note

    Published on:

  34. Hospitalized patients who presented within the last 24 h with a bacterial infection were recruited. Participants were assigned into sepsis and uncomplicated infection groups. In addition, healthy volunteers we...

    Authors: Velma Herwanto, Benjamin Tang, Ya Wang, Maryam Shojaei, Marek Nalos, Amith Shetty, Kevin Lai, Anthony S. McLean and Klaus Schughart

    Citation: BMC Research Notes 2021 14:76

    Content type: Data note

    Published on:

  35. Development of sequencing technology has opened up vast opportunities for tree genomic research in the tropics. One of the aforesaid technologies named ONT (Oxford Nanopore Technology) has attracted researcher...

    Authors: Iskandar Zulkarnaen Siregar, Fifi Gus Dwiyanti, Rahadian Pratama, Deden Derajat Matra and Muhammad Majiidu

    Citation: BMC Research Notes 2021 14:75

    Content type: Data note

    Published on:

  36. Data on gender representation in food and beverage advertisements may allow for a better understanding of how the food industry is targeting different audiences based on gender. Nonetheless, scant research on ...

    Authors: Lucila Rozas, Peter Busse, Joaquin Barnoya and Alejandra Garrón

    Citation: BMC Research Notes 2021 14:63

    Content type: Data note

    Published on:

  37. Neonatal mortality is a global public health problem, and the efforts to reduce child mortality is one of the goals of the 2030 Agenda for Sustainable Development, launched in 2015 by the United Nations. The a...

    Authors: Lais Baroni, Rebecca Salles, Samella Salles, Marcel Pedroso, Jefferson Lima, Igor Morais, Lucas Carraro, Raphael de Freitas Saldanha, Carlos Sousa, Carlos Cardoso, Balthazar Paixño, Sérgio Cruz, Eduardo Ogasawara, Patrícia de Morais Mello Boccolini and Cristiano Siqueira Boccolini

    Citation: BMC Research Notes 2021 14:55

    Content type: Data note

    Published on:

  38. Altitude integrates changes in environmental conditions that determine shifts in vegetation, including temperature, precipitation, solar radiation and edaphogenetic processes. In turn, vegetation alters soil b...

    Authors: Alexia Stokes, Guillermo Angeles, Fabien Anthelme, Eduardo Aranda-Delgado, Isabelle Barois, Manon Bounous, Nereyda Cruz-Maldonado, Thibaud Decaëns, Stéphane Fourtier, Grégoire T. Freschet, Quentin Gabriac, Daniel Hernández-Cáceres, Leonor Jiménez, Jing Ma, Zhun Mao, Beatriz Eugenia Marín-Castro…

    Citation: BMC Research Notes 2021 14:54

    Content type: Data note

    Published on:

  39. Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today i...

    Authors: Ulykbek Kairov, Askhat Molkenov, Saule Rakhimova, Ulan Kozhamkulov, Aigul Sharip, Daniyar Karabayev, Asset Daniyarov, Joseph H.Lee, Joseph D.Terwilliger, Ainur Akilzhanova and Zhaxybay Zhumadilov

    Citation: BMC Research Notes 2021 14:45

    Content type: Data note

    Published on:

  40. The purpose of this data set is to capture the complete diurnal (i.e., daily) transcriptome of fully expanded third leaves from the C4 panacoid grasses sorghum (Sorghum bicolor), maize (Zea mays), and foxtail mil...

    Authors: Xianjun Lai, Claire Bendix, Yang Zhang, James C. Schnable and Frank G. Harmon

    Citation: BMC Research Notes 2021 14:24

    Content type: Data note

    Published on:

  41. The urgent need for novel antibiotics cannot be overemphasized. Hafnia alvei A23BA was isolated from plant rhizosphere as part of an effort to recover novel antibiotic-producing bacterial strains from soil sample...

    Authors: Opeyemi K. Awolope, Noelle H. O’Driscoll, Alberto Di Salvo and Andrew J. Lamb

    Citation: BMC Research Notes 2021 14:8

    Content type: Data note

    Published on:

  42. This data paper aims to provide the data set of a practical method to health, safety, and environmental risk assessment to assess and rank potential threats/hazards and to prevent and decrease the accidents an...

    Authors: Alireza Dehdashti, Farin Fatemi, Muhammadreza Janati, Fatemeh Asadi and Marzieh Belji Kangarloo

    Citation: BMC Research Notes 2020 13:554

    Content type: Data note

    Published on:

  45. Passalora sequoiae (family Mycosphaerellaceae) causes a twig blight on Leyland cypress that requires numerous fungicide applications annually to minimize economic losses for ornamental plant nursery and Christmas...

    Authors: Warren E. Copes, Jorge Ibarra Caballero, Ebrahiem Babiker, Jane E. Stewart, Valerie A. Orner, Alan S. Windham and Renee S. Arias

    Citation: BMC Research Notes 2020 13:505

    Content type: Data note

    Published on:

  46. The Brown trout is a salmonid species with a high commercial value in Europe. Life history and spawning behaviour include resident (Salmo trutta m. fario) and migratory (Salmo trutta m. trutta) ecotypes. The main...

    Authors: J. Fibla, N. Oromi, M. Pascual-Pons, J. L. Royo, A. Palau and M. Fibla

    Citation: BMC Research Notes 2020 13:503

    Content type: Data note

    Published on:

  47. The availability of matched sequencing data for the same sample across different sequencing platforms is a necessity for validation and effective comparison of sequencing platforms. A commonly sequenced sample...

    Authors: Shannon N. Fenlon, Yuemin Celina Chee, Jacqueline Lai Yuen Chee, Yeen Hui Choy, Alexis Jiaying Khng, Lu Ting Liow, Kurosh S. Mehershahi, Xiaoan Ruan, Stephen W. Turner, Fei Yao and Swaine L. Chen

    Citation: BMC Research Notes 2020 13:487

    Content type: Data note

    Published on:

  48. The data herein represents multiple gauge sets and multiple radar sites of like-type Doppler data sets combined to produce populations of ordered pairs. Publications spanning decades yet specific to Doppler ra...

    Authors: Jesse W. Lansford, Tyson H. Walsh, T. V. Hromadka II and P. Rao

    Citation: BMC Research Notes 2020 13:482

    Content type: Data note

    Published on:

  49. Respiratory tract diseases (RTDs) are among the top five leading causes of death worldwide. Mortality rates due to respiratory tract diseases (MRRTDs) follow a spatial pattern and this may suggest a potential ...

    Authors: Elahe Pishgar, Alireza Mohammadi, Nasser Bagheri and Behzad Kiani

    Citation: BMC Research Notes 2020 13:469

    Content type: Data note

    Published on:

  50. Colorectal cancer (CRC) is the third most common cancer across the world that multiple risk factors together contribute to CRC development. There is a limited research report on impact of nutritional risk fact...

    Authors: Neda Firouraghi, Nasser Bagheri, Fatemeh Kiani, Ladan Goshayeshi, Majid Ghayour-Mobarhan, Khalil Kimiafar, Saeid Eslami and Behzad Kiani

    Citation: BMC Research Notes 2020 13:466

    Content type: Data note

    Published on:

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keletal preparations of wt (a), homozygous Dll1GFPHAstopSF (b) and Dll1SF d15.5 fetuses. © Fig. 2CActivity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo
To visualise DLL1 in tissues, for sorting and enrichment of DLL1-expressing cells, and to efficiently purify DLL1 protein complexes Schuster-Gossler et al tagged DLL1 in mice with AcGFPHA or Strep/FLAG.

Sydney,Australia: An indigenous dancer waits his turn in a competition during the Homeground festival © © PomInOzAn exploration of the sociodemographic and health conditions associated with self-rated wellbeing for Aboriginal and Torres Strait Islander adults
Gall et al conducted exploratory analyses to ascertain factors associated with self-rated wellbeing for Aboriginal and Torres Strait Islander adults.

big fish eats medium sized fish eats little fish © © samarttiwA meta-collection of nitrogen stable isotope data measured in Arctic marine organisms from the Canadian Beaufort Sea, 1983–2013
A total of 1077 entries from the Arctic food web are described in this Data Note by Ehrman et al, from top marine mammal predators to primary producers.

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October: Focus on Stem Cells

With Stem Cell Awareness day on the 13th October this year we have compiled an article collection from across different BMC Series journals covering aspects of basic stem cell biology; in vitro differentiation studies; stem-cell based therapy studies for various conditions in animal models; technical advancements and ethical issues. 

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September: Patient and public involvement in research

In recognition of World Patient Safety Awareness day on 17th September, the BMC Series presents a focus issue on Patient and Public Involvement (PPI) in research.  We have collated free-to-read content from across our journals - showcasing patient perspectives, research into the study of PPI, and engaging public partners as co-authors in research.

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