Figure 2

Experiment 4: The two colour fluorescent dye signals are converted into intensity ratio profiles. The upper and lower ratio threshold is 1.3 and 0.7 respectively. A) Ideogram showing all chromosomes. Differences seen between the amplified DNA and the non-amplified DNA in the male control are illustrated. 17 duplicated and 134 deleted clones were detected. Bars to the right (blue) indicate gains and to the left (red) losses.B) Chromosome 4 ratio plot. A deletion can be seen at chromosome 4p16 and duplicated single clone alterations at location 4q13.1, 4q13-4q21, 4q28.1 and 4q32. C) Chromosome X ratio plot. A deletion at location Xp22.33 and duplications at Xp21.1-21.31, Xp21.1-21.32 and Xq28 can be seen.