Figure 1

Dendrogram of the BRICHOS superfamily. 12 groups are clearly distinguished; proSP-C (pulmonary surfactant protein C precursor), group C, GKN2 and GKN1 (gastrokine-2 and -1), group B, LECT1 (chondromodulin-1), TNMD (tenomodulin), the divergent group, group A, and ITM2A, ITM2C and ITM2B (integral membrane protein 2 A, C and B). UniProtKB sequences are denoted by accession number and identifier, e.g: O43736|ITM2A_HUMAN. GenomeLKPG sequences are denoted by their external identifier (Ensembl or NCBI) prepended with the organism's NCBI Taxonomic identifier, e.g. 13618.ENSMODP00000005214. Red circles highlight the bootstrap numbers for each family. Only sequences with less than 90% sequence identities are shown.