Figure 3

Conservation, secondary structure and native disorder. The upper half of each figure shows GC positions within each family in blue (strictly conserved in dark blue). The lower half shows secondary structure predictions for the representative sequences in colored letters (red H for helix, green E for strand, black C for coil) while the background shading indicates prediction reliability (the stronger the better). Red rectangles indicate native disorder. The alignment is an excerpt from a full alignment of the superfamily, showing only one human representative from each family, and a Caenorhabditis sequence for group A, suppressing any resulting fully gapped positions.