From: In silico investigation of ADAM12 effect on TGF-β receptors trafficking
abbreviation | definition |
---|---|
p R | Receptors production rate |
k ie | Internalization rate towards endosome |
K re | Recycling rate from endosome |
k ic | Internalization rate towards caveosome |
K rc | Recycling rate from caveosome |
k cd | Constitutive degradation rate |
k lid | Ligand induced degradation rate |
k a | LRC formation rate |
LRC | Ligand-receptor complex |
R m | Receptor complexes in the cell membrane |
R e | Receptor complexes in the endosome |
R c | Receptor complexes in the caveosome |
LRC m | LRCs at the cell surface membrane |
LRC e | LRCs in the endosome |
LRC C | LRCs in the caveosome |
CIR | Constitutive to Induced degradation Ratio |