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Table 4 Association of ESR1 and APOE genetic polymorphisms and hypercholesterolemia

From: Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity

    Cholesterol < 5 mmol/L Cholesterol > 5 mmol/L OR CI Test p value
ESR1* Alleles S 87 14 1 1-1 X2 = 6.391
   L 77 30 2.421 1.242-4.72 df = 1
        p = 0.011
  Genotypes SS 22 3 1 1-1 X2 = 7.147
   LS 43 8 1.364 0.3288-5.661 df = 2
   LL 17 11 4.745 1.141-19.73 p = 0.028
APOE** Alleles ε2 21 1 1 1-1 X2 = 11.46
   ε3 123 32 5.463 0.6664-44.79 df = 2
   ε4 14 11 16.5 1.366-199.2 p = 0.003
  Genotypes 22 2 0 1 1-1 X2 = 14.98
   23 15 0 8.413e-006 8.413e-006-8.413e-006 df = 4
p = 0.004
   24 2 1 1.285e+008 2.495e+007-6.62e+008  
   33 48 11 5.891e+007 2.27e+007-1.529e+008  
   34 12 10 2.1424+0088 7.876e+007-5.825e+008  
  1. APOE = apolipoprotein E
  2. ESR1 = estrogen receptor alpha
  3. * Means+/-SD of SS, LS and LL were 4.2+/-0.9; 4.56+/-0.97; 4.81+/-0.89, respectively
  4. ** Means+/-SD of 22, 23, 24, 33 and 34 were 3.65+/-0.92; 3.89+/-0.58; 3,83+/-1.44; 4,51+/-0.74; 4.51+/-0.95, respectively