Table 1 Overview of GAPDH expression in different tumor and non-tumor cell lines as a consequence of the development of a hypoxic cellular microenvironment.
From: Absence of GAPDH regulation in tumor-cells of different origin under hypoxic conditions in – vitro
Cell line or type | Origin | Genetic mutations | GAPDH overexpression | Ref. | Ref. |
|---|---|---|---|---|---|
(-/+) | under hypoxia | GAPDH | mutations | ||
U373 – MG | Malignant glioma cells (Human) | -Apoptosis resistant mutant P53 | (-) | [40], | |
-Peroxisome proliferator activated receptor – γ | |||||
-PTEN mutation | [41], | ||||
GaMG | Malignant glioma cells (Human) | (-) | (-) | ||
U251 | malignant glioma cells (Human) | Mutated p53 | (-) | [40] | |
P14ARF/P16 deletion | |||||
Bovine articular chondrocytes | Chondrocytes (Bovine) | Not determined | (-) | [37] | (-) |
LNCap | Prostate adenocarcinoma cells | (-) | (+) | [34] | [27] |
(Human) | |||||
ATII | Alveolar epithelial cells (Rat) | (-) | (+) | [26] | [26] |
SiHA | Spontaneous cervical cancer cells (Human) | (-) | (+) | [35] | [36] |
Wild type p53 | |||||
MBEC4 | Brain capillary endothelial cells | (-) | (+) | [37] | [37] |
(Mouse) | |||||
EC | Endothelial cells (Human) | - Not determined | (+) | [39] | |
- Mutated epithelial cells are present | |||||
HepG2 | Human Hepatocellular Carcinoma | Raf inactive (-) | (-) | [This Paper] | |
Wild type p53 | |||||
Wild type Retinoblastoma | |||||
Hep-3-B | Human Hepatocellular Carcinoma | Wild type p53 | (-) | [This Paper] | |
Absence of RB transcripts | |||||
Deletion p53 gene | |||||
Hep.1-6 | Mouse Hepatocellular Carcinoma | - Not determined | (-) | [This Paper] | [45] |
HCT-116 | Colon cancer cell line (Human) | K-ras (+) | (-) | (-) | [46] |
HT-29 | Colon cancer cell line (Human) | (-) | (-) | (-) | |
A-549 | Lung cancer cell line (Human) | k-Ras (+) | (-) | (-) | |
c-RAS (+) |