Table 2 Risk of BRCA2 associated cancers in descendants of most distant ancestor carrying the 13q haplotype1
From: No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees
Pedigree Identifier | # descendants | Cancer type | # of observed cancers | # of expected cancers | p-value |
|---|---|---|---|---|---|
9775803 | 380 | Breast | 1 | 1.41 | 0.755 |
Prostate | 9 | 2.15 | 0.0004 | ||
9445402 | 206 | Breast | 2 | 0.79 | 0.188 |
Melanoma | 2 | 0.27 | 0.031 | ||
Prostate | 6 | 0.70 | 0.00009 | ||
99902052 | NA | NA | NA | NA | NA |
9434307 | 1,863 | Breast | 5 | 5.36 | 0.621 |
Melanoma | 4 | 2.25 | 0.190 | ||
Prostate | 22 | 7.13 | 0.000006 | ||
Ovary | 1 | 0.88 | 0.585 | ||
9435901 | 204 | Breast | 1 | 0.73 | 0.516 |
Melanoma | 1 | 0.30 | 0.261 | ||
Prostate | 5 | 1.17 | 0.007 |