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Table 2 Risk of BRCA2 associated cancers in descendants of most distant ancestor carrying the 13q haplotype1

From: No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

Pedigree Identifier # descendants Cancer type # of observed cancers # of expected cancers p-value
9775803 380 Breast 1 1.41 0.755
   Prostate 9 2.15 0.0004
9445402 206 Breast 2 0.79 0.188
   Melanoma 2 0.27 0.031
   Prostate 6 0.70 0.00009
99902052 NA NA NA NA NA
9434307 1,863 Breast 5 5.36 0.621
   Melanoma 4 2.25 0.190
   Prostate 22 7.13 0.000006
   Ovary 1 0.88 0.585
9435901 204 Breast 1 0.73 0.516
   Melanoma 1 0.30 0.261
   Prostate 5 1.17 0.007
  1. 1 The following cancers were considered to be BRCA2 associated cancers: breast, prostate, ovarian, pancreatic, and melanoma.
  2. 2Pedigree 9990205 was contributed from a collaborator outside of Utah, and does not link to the UPDB. The number of cancers in descendants from this pedigree cannot be determined.