No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

BMC Research Notes

Table 3 BRCA2 variants of unknown significance observed in Utah high-risk prostate cancer pedigrees

Exon/Intron	Nucleotide change	Amino Acid change	Desc. On BIC¹	No. found in prostate cases /total found /no. with valid results²	Pedigree segregation
11	5972C>T	M1915T	UV(7)	0/1/12	--³
I14	IVS14-62A>G	Intronic	NA	1/1/12	--

¹UV = unclassified variant. Value in parentheses represents the number of times there is an entry for the given mutation in the BIC database.
²Valid result requires that the sequencing reaction is of sufficient quality as to detect the polymorphism.
³This variant was previously reported to be present in prostate cancer cases by others.²¹

ISSN: 1756-0500