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Table 2 Odds ratios for the association of five polymorphisms with risk of nasopharyngeal carcinoma (NPC) in southern China (Phase I cohort)

From: Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China

Gene-SNP

Genotype

Cases (%)

Controls (%)

OR

95%CI

p value

All subjects*

 

(n = 358)

(n = 629)

   

   CYP2E1-rs2031920

CC

228 (64.0)

412 (66.0)

1.0

  
 

CT

108 (30.3)

186 (29.8)

1.06

0.78-1.42

0.72

 

TT

20 (5.6)

26 (4.2)

1.21

0.63-2.34

0.57

   CYP2E1-rs6413432

TT

188 (56.0)

360 (59.6)

1.0

  
 

AT

121 (36.0)

202 (33.4)

1.10

0.82-1.49

0.52

 

AA

27 (8.0)

42 (7.0)

1.07

0.61-1.85

0.82

   GSTP1-rs947894

AA

181 (65.1)

346 (66.3)

1.0

  
 

AG

84 (30.2)

159 (30.5)

0.98

0.70-1.37

0.91

 

GG

13 (4.7)

17 (3.3)

1.41

0.65-3.03

0.39

   MPO-rs2333227

GG

223 (69.0)

381 (69.3)

1.0

  
 

GA

93 (28.8)

157 (28.6)

0.95

0.69-1.30

0.74

 

AA

7 (2.2)

12 (2.2)

1.15

0.43-3.07

0.78

   NQO1-rs1800566

CC

96 (27.7)

169 (27.3)

1.0

  
 

CT

159 (45.8)

320 (51.6)

0.87

0.63-1.21

0.41

 

TT

92 (26.5)

131 (21.1)

1.18

0.81-1.72

0.39

EBV/IgA/VCA+**

 

(n = 341)

(n = 280)

   

   CYP2E1-rs2031920

CC

214 (63.1)

186 (66.9)

1.0

  
 

CT

105 (31.0)

82 (29.5)

1.10

0.77-1.58

0.59

 

TT

20 (5.9)

10 (3.6)

1.39

0.61-3.15

0.43

   CYP2E1-rs6413432

TT

175 (54.7)

160 (58.8)

1.0

  
 

AT

118 (36.9)

93 (34.2)

1.12

0.79-1.60

0.52

 

AA

27 (8.4)

19 (7.0)

1.03

0.54-1.98

0.92

   GSTP1-rs947894

AA

172 (65.4)

168 (69.7)

1.0

  
 

AG

79 (30.0)

67 (27.8)

1.09

0.73-1.63

0.66

 

GG

12 (4.6)

6 (2.5)

1.80

0.65-5.01

0.26

   MPO-rs2333227

GG

217 (70.2)

159 (66.5)

1.0

  
 

GA

85 (27.5)

72 (30.1)

0.84

0.57-1.23

0.37

 

AA

7 (2.3)

8 (3.4)

0.77

0.27-2.22

0.63

   NQO1-rs1800566

CC

91 (27.6)

73 (26.6)

1.0

  
 

CT

151 (45.8)

139 (50.6)

0.88

0.60-1.31

0.53

 

TT

88 (26.7)

63 (22.9)

1.11

0.70-1.74

0.66

  1. OR = odds ratio.
  2. CI = confidence interval.
  3. *Cases and controls in this group were a mix of IgA+ and IgA- individuals.
  4. **Cases and controls in this group were only IgA+ individuals.