Table 4 Sensitivity analyses (SA): Regression coefficients with 95% confidence intervals
Variable | Main analysis | SA1: Evaluable data for all variables | SA2: 75% subsample | SA3: Remaining 25%, variables from SA2 | SA4: 0-12 month improvement | SA5: Dependent variable First Symptom |
|---|---|---|---|---|---|---|
1. Symptom Score at baseline (0-10)* | 0.74 (0.66 to 0.81) | 0.75 (0.66 to 0.83) | 0.73 (0.65 to 0.81) | 0.74 (0.59 to 0.90) | 0.75 (0.67 to 0.83) | 0.72 (0.64 to 0.79) |
2. SF-36 Physical Function Scale at baseline (0-100) | 0.01 (0.004 to 0.02) | 0.01 (0.01 to 0.02) | 0.01 (0.003 to 0.02) | 0.01 (0.002 to 0.03) | 0.01 (0.002 to 0.02) | 0.01 (0.0003 to 0.02) |
3. Education level (1-3) | 0.31 (0.14 to 0.49) | 0.32 (0.10 to 0.54) | 0.35 (0.15 to 0.56) | 0.31 (-0.06 to 0.69) | 0.30 (0.11 to 0.50) | 0.44 (0.22 to 0.66) |
4. SF-36 General Health Item at enrolment (1-5) | -0.29 (-0.47 to -0.11 | -0.26 (-0.48 to -0.05) | -0.23 (-0.43 to -0.03) | -0.63 (-1.03 to -0.23) | -0.24 (-0.44 to -0.05) | -0.23 (-0.44 to -0.01) |
5. Main diagnosis J00-J99 Respiratory system** | 0.77 (0.29 to 1.25) | 0.68 (0.13 to 1.23) | 0.76 (0.24 to 1.27) | 0.65 (-0.46 to 1.77) | --- | 0.67 (0.10 to 1.25) |
6. Disease duration (years) | -0.02 (-0.03 to -0.01) | -0.02 (-0.03 to -0.0005) | --- | --- | -0.02 (-0.03 to -0.002) | --- |
7. Main diagnosis N00-N99 Genitourinary system** | -0.63 (-1.10 to -0.16) | -0.62 (-1.18 to -0.07) | --- | --- | --- | -0.72 (-1.28 to -0.16) |
8. Physiotherapy in pre-study year (sessions) | -0.01 (-0.02 to -0.002) | --- | --- | --- | -0.01 (-0.02 to -0.01) | -0.01 (-0.02 to -0.004) |
9. Physician's therapy goal at baseline (1-6) | 0.12 (0.02 to 0.22) | 0.18 (0.06 to 0.30) | 0.17 (0.06 to 0.28) | 0.01 (-0.22 to 0.23) | 0.18 (0.07 to 0.29) | 0.27 (0.15 to 0.40) |
10. Psychotherapy in pre-study year (sessions) | --- | -0.01 (-0.02 to -0.004) | --- | --- | --- | --- |
11. Wage earner** | --- | --- | 0.90 (0.18 to 1.62) | -0.66 (-2.28 to 0.97) | --- | 1.04 (0.24 to 1.84) |
12. Non-AM medications in month 0-6 (patient-months) | --- | --- | --- | --- | -0.03 (-0.05 to -0.01) | -0.02 (-0.04 to -0.002) |
13. Main diagnosis C00-D48 Neoplasms** | --- | --- | --- | --- | --- | 0.70 (0.08 to 1.32) |