Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells

Table 1 Comparison of G₂/M phase induction by α-santalol in A431 cells and UACC-62 cells

Time of treatment	Conc. of α-santalol (μM)	Percentage of G₂/M phase induction by α-santalol as compared to control *
		p53 mutated human epidermoid carcinoma A431 cells	p53 wild-type human melanoma UACC-62 cells
6 h	50	49.1	70.9
	75	48.8	65.2
12 h	50	171.1	148.7
	75	235.5	149
24 h	50	27.2	226
	75	285	305.5

*: Data were expressed as the percentage of the induction of α-santalol treated groups in G2/M phase to untreated controls.

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