Non-coding RNAs change their expression profile after Retinoid induced differentiation of the promyelocytic cell line NB4

Table 1 miRNAs with altered expression after ATRA induced differentation in NB4 cells by microarray analysis.

Name	P-value	NB4 expression	NB4 + ATRA expression	Map	TvsUT	Validation	Densitometry
hsa-mir-017-precNo2	0,0447	2,944	1,388	13q31	Down	down	6.0 fold
hsa-mir-186-prec	0,0447	0,864	0,891	1p31	Up	up	0.5 fold
hsa-mir-193-precNo1	0,0385	1,031	0,847	17q11.2	Down	down	1.2 fold
hsa-mir-195-prec	0,0373	2,618	1,954	17p13	Down	down	0.8 fold
hsa-mir-025-prec	0,0351	7,56	3,157	7q22	Down	down	4.1 fold
hsa-let-7a-1-prec	0,0243	0,962	0,889	9q22.2	Down	up	3.2 fold
hsa-mir-215-precNo2	0,0104	0,691	0,792	1q41	Up	up	0.5 fold
hsa-mir-223-prec	0.0232	8.68	17.08	Xq12-13.3	Up	up	10.6 fold

In the table are showed for each miRNA the name (hsa = human miRNAs), the P-value, the normalization of two independent experiment (NB4 = untreated; NB4-ATRA = treated); the locus map (map); the expression in treated versus untreated cells (T vs UT) and the expression (T vs UT) after northen blot validation (validation: up = upregulation; down = downregulation); the densitometry shows the average of three independent experiments.

ISSN: 1756-0500