Figure 2

Up-regulation of ribosomal protein mRNAs upon BDNF-treatment. Gene expression analysis was carried out as in Figure 1. pcDNA3.1-CMV control plasmid -treated muscles are shown as dark grey bars and pcDNA3.1-CMV-BDNF-TTC plasmid treated muscles as light grey bars. A) Transcripts for ribosomal proteins Rps13, Rps17, Rpl41 and Rpl44 were unaffected (P = 0.854, P = 0.472, P = 0.735 and P = 0.522, respectively) by BDNF-treatment at age of 70 days. B) Transcripts for ribosomal proteins were increased by BDNF-treatment at age of 110 days: Rps13 (8.6 fold, P < 0.01), Rps17 (13.1-fold, P < 0.01), Rpl41 (17.4-fold, P < 0.01) and Rpl44 (7.1-fold, P < 0.05). Error bars indicate standard error of mean. Symbols ** and * denote statistical significance level P ≤ 0.01 and P ≤ 0.05, respectively.