Table 1 Factor Analysis [12] of Mania and Depression Symptoms
Factor No. Name | Scale Items | Mean Contribution To HDRS-21 + YMRS Total Score | Eigenvalue | Pearson Correlation Coefficient with CGI (p value) |
|---|---|---|---|---|
1. Sleep disturbance | YMRS 4 Sleep HDRS-21 4 Early Insomnia HDRS-21 5 Middle Insomnia HDRS-21 6 Late Insomnia | 13.90% | 2.82 | 0.073 (0.301) |
2. Psychomotor activity | YMRS 1 Elevated Mood YMRS 2 Increased Psychomotor Activity YMRS 6 Rapid Speech HDRS-21 9 Agitation | 19.70% | 2.53 | 0.253 (< .001)* |
3. Insight | YMRS 11 Lack of Insight HDRS 17 Lack of Insight | 0.40% | 2.26 | -0.043 (0.541) |
4. Work impairment/Somatization | HDRS-21 7 Work and Activities HDRS-21 11 Somatic Anxiety HDRS-21 13 General Somatic Symptoms | 12.80% | 2.10 | 0.293 (< .001)* |
5. Irritability | YMRS 5 Irritability YMRS 9 Disruptive Aggressive Behavior HDRS-21 1 Depressed Mood | 20.70% | 1.83 | 0.181 (< .01)* |
6. Variation/Derealization/Obsession | HDRS-21 18b Diurnal Variation HDRS-21 19 Depersonalization and Derealization HDRS-21 21 Obsessional and Compulsive Symptoms | 2.90% | 1.70 | 0.073 (0.303) |
7. Sexuality | YMRS 3 Sexual Interest HDRS-21 14 Genital Symptoms (reverse) | 3.80% | 1.48 | -0.120 (0.089) |
8. Guilt/Suicidality | HDRS-21 2 Feelings of Guilt HDRS-21 3 Suicide | 4.80% | 1.38 | 0.256 (< .001)* |
9. Appearance/GI | YMRS 10 Appearance HDRS-21 12 Somatic Symptoms (gastrointestinal) HDRS-21 16 Loss of Weight | 3.10% | 1.28 | 0.298 (< .001)* |
10. Thought disorder | YMRS 8 Content HDRS-21 20 Paranoid Symptoms | 6.40% | 1.25 | 0.012 (0.871) |
11. Retardation/Hypochondriasis | HDRS-21 8 Psychomotor Retardation (reverse) HDRS-21 15 Hypochondriasis | 9.90% | 1.08 | 0.118 (0.094) |