Implication of plasma miR-92a. A: Plasma miR-92a expression levels in acute leukemia patients and normal controls. B: Cell to plasma ratio of miR-92a expression. C: ROC curve of cell to plasma ratio in acute leukemia. D: The miR-92a expression in cells and supernatant. Cells were cultured under serum-free conditions for 24 hours, and then total RNA was extracted from both cells and supernatant. The expression levels of miR-92a in the supernatant are shown in closed boxes, and those in cells are show in open boxes.