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Table 2 Details of accepted trials

From: Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: An update of systematic review evidence

Article DS Study design GIC treatment group Resin treatment group Outcome measure Evaluation Dentition/Teeth/Restoration Study period
    Type of material BSL N n LTF Type of material BSL N n LTF   Criteria Method   
   Dichotomous datasets
Oba et al., 2009 [32] 01 SM Ketac Molar 91 56 6 35 Fissurit F 116 81 8 35 Caries Caries present Visual First permanent molars 3 years
Barja-Fidalgo et al., 2009 [33] 02 PG Fuji IX 46 46 1 0 Delton 46 46 2 0 Caries Cavity that had clearly penetrated the dentin or if a radiolucency in dentin could be seen on the bitewing X- ray Visual and X-Ray First permanent molars 6 months
  03    46 21 2 25   46 28 7 18      5 years
Karlzén-Reuterving and van Dijken, 1995 [20] 04 SM Fuji III 74 72 1 2 Delton 74 72 3 2 Caries Caries present Visual First permanent molars 3 years
Arrow and Riordan, 1995 [21] 05 SM Ketac Fil 465 412 6 53 Delton 465 412 31 53 Caries When a cavity was present Visual First permanent molars Mean 3.64 (SD 0.11) years
Williams et al., 1996 [22] 06 SM Fuji III 430 295 19 135 Delton 430 295 4 135 Caries Caries present Visual First permanent molars 2 years
  07    430 222 22 208   430 222 16 208      4 years
Rock et al., 1996 [23] 08 SM Baseline 172 160 3 12 Fluoro- Shield 172 162 0 10 Caries Caries present Visual First permanent molars 6 months
  09    172 157 6 15   172 158 1 14      1 year
  10    172 130 14 42   172 132 2 40      2 years
  11    172 124 18 48   172 129 3 43      3 years
Kerrvanto- Seppälä et al., 2008 [24] 12 SM Fuji III 1025 657 27 368 Delton 1025 657 7 368 Caries If dentine caries was detected Visual 2nd permanent molars 3 years
Beiruti et al., 2006 15 PG Fuji IX 180 180 0 0 Visio Seal 180 180 1 0 Caries Caries present Visual First permanent molars 1 year
[26] 16    180 154 0 26   180 161 6 19      2 years
  17    180 154 3 26   180 138 13 42      3 years
  18    180 143 7 37   180 123 21 57      4 years
  19    180 80 8 100   180 76 27 104      5 years
Poulsen et al., 2006 [27] 20 SM Fuji III 364 364 34 0 Delton 364 364 10 0 Radiograp-hically carious Lesions into dentine X-Ray First permanent molars 2.3 - 3.2 years
  21    364 364 23 0   364 364 10 0 Clinically carious Danish municipal dental service criteria Visual   
Forss and Halme, 19981 [28] 22 SM Fuji III 166 97 23 69 Delton 166 97 16 69 Caries Caries lesion present/Arrested caries present Visual Permanent molars/premolars 7 years
Mejàre and Mjör, 1990 [29] 24 SM Fuji III 44 36 0 8 Delton 117 75 6 42 Caries Caries present Visual Permanent molars/premolars 5 years
  25    44 36 0 8 Concise 47 18 2 29      
Boksmann et al., 1987 [30] 26 SM Fuji III 125 116 0 9 Concise 122 115 0 7 Caries Caries present Visual Permanent molars 6 months
Poulsen et al., 2001 [31] 27 SM Fuji III 170 116 44 54 Delton 170 116 13 54 Caries White, yellow, brown discoloration of the fissure or cavity Visual First permanent molars 3 years
Forss et al., 19941 [37] 28 SM Fuji III 166 151 7 15 Delton 166 151 7 15 Caries Caries lesion present/Arrested caries present Visual Permanent molars/premolars 2 years
Williams and Winter, 1981 [38] 30 SM ASPA No info 4862 642 No info Concise No info 4862 932 No info Caries Caries present Visual First permanent molars 3.84 years
Article DS Continuous datasets
   Patient character-istics/potential confounders* Type of material N x SD LTF Type of material N x SD LTF Outcome measure Criteria Method Dentition/Teeth/Restoration Study period
Songpaisan et al., 1995 [25] 13 PG Fuji III 128 0.48 1.03 14% Delton 133 0.05 0.57 14% DFS increment DFS Visual Permanent molars 2 years
  14    128 1.82 2.60    133 0.98 1.72   DMFS increment DMFS    
Forss and Halme, 19981 [28] 23 SM Fuji III 97 0.13 0.40 69 Delton 97 0.13 0.37 69 Caries increment on approximal tooth surfaces adjacent to materials Caries lesion present/Arrested caries present Visual Permanent molars/premolars 7 years
Forss et al., 19941 [37] 29 SM Fuji III 151 0.09 0.34 15 Delton 151 0.13 0.41 15      2 years
Article Place of trial Age of patients Patient characteristics/inclusion/exclusion criteria Fluoride exposure from other sources              
Oba et al., 2009 [32] Study conducted in a boarding school in the city of Kırıkkale/Turkey 7-11 years Children received instructions on good oral health care and were individually shown how to clean their teeth prior to the start of the treatment; inclusion criteria were: (1) sound pits and fissures in fully erupted first molars; and (2) pits and fissures diagnosed with an early enamel lesion; exclusion criteria were: (1) partly erupted first molar; (2) an obvious cavity in the occlusal surface; and (3) the presence of a restoration or a sealant (or part of it) in the pit and fissure system; Resin-based fissure sealant material containing fluoride
Barja-Fidalgo et al., 2009 [33] Study carried out in the Department of Paediatric Dentistry, Rio de Janeiro State University, Rio de Janeiro/Brazil; mean age 6.8 years (±0.98 SD) With at least 1 permanent first molar erupted and 2 or more primary molars decayed, filled, or extracted due to caries; most from low socio-economic background with high caries-risk; the participants were also given oral hygiene instructions and dietary counselling; those who had dental care needs were referred to the paediatric dental clinic for appropriate restorative and surgical treatment; participants reported brushing their teeth daily, 11% reported using dental floss regularly, and 67% had a dental check-up once a year first molars that presented a sound occlusal surface or occlusal caries at the D1 level (non-cavitated enamel lesion) entered the study; low patient compliance and high saliva contamination during treatment reported. -
Karlzén-Reuterving and van Dijken, 1995 [20] Children from Umea/Sweden mean age 7 years, 1 month Teeth without clinical evidence of caries were sealed -
Arrow and Riordan, 1995 [21] Children from Perth/Australia mean age 7 (SD 0.72) years With sound, unsealed, homologous 1st permanent molars -
Williams et al., 1996 [22] Children from Suffolk/UK 6-8 years Recently erupted visually caries free 1st permanent molars; resealed teeth were excluded Fluoride concentration of drinking water 0.1 - 0.5 mgF/l
Rock et al., 1996 [23] Children from Tamworth, Staffordshire/UK 7-8 years Caries free fully erupted 1st permanent molars; children had evidence of caries in primary teeth The resin-based sealant FluroShield contains fluoride; fluoride concentration of drinking water 0.13 ppm
Kerrvanto- Seppälä et al., 2008 [24] Children from Varkaus/Finland 12-16 years 2nd permanent molars considered to be at risk of caries were sealed; teeth with lost resin sealant were resealed and not excluded from the study. -
Beiruti et al., 2006 [26] Children from Damascus/Syria mean age 7.8 years No cavities in primary teeth; inclusion criteria: sound pits and fissures in fully erupted 1st permanent molars, pits and fissures with early enamel lesion and/or small dentinal lesion; exclusion criteria: partly erupted tooth, obvious occlusal cavity, presence of restoration or sealant in pits and fissures. -
Poulsen et al., 2006 [27] Children from Vaerlose/Denmark 8-13 years Mean DMFS was between 0.5 and 0.7 for 12-year-old children and between 1.4 and 1.8 for 13-year-old children; sound surfaces, and surfaces with initial or arrested caries (white or brown fissures) were sealed, if the dentist's clinical assessment indicated a caries risk; only children with both clinical and radiographic data were included in the present study Fluoride content of the drinking water 0.25 ppm; all children commonly use fluoridated toothpaste
Forss and Halme, 2006 [28] Children from Raisio/Finland 5-14 years Contra-lateral pair of newly erupted non-sealed permanent molars or premolars -
Mejàre and Mjör, 1990 [29] - mean age 9.2 (5.7 - 15.0) years - -
Boksmann et al., 1987 [30] - 6-18 years Patients had not received topical fluoride treatment for at least 3 months prior. Fluoride content of the drinking water 1 ppm or more
Poulsen et al., 2001 [31] Children from Damascus/Syria 7 years Only children with at least one pair of caries free permanent 1st molars or with incipient lesions; average DMFT 0.6 -0.7. -
Forss et al., 1994 [37] Children from Raisio/Finland 5-14 years Contra-lateral pair of newly erupted non-sealed permanent molars or premolars -
Williams and Winter, 1981 [38] - 6-8 and 11-13 years - -
Songpaisan et al., 1995 [25] Children from Bangkok/Thailand 12-13 years From very low to medium socio-economic background; children with at least 3 sound permanent molars (erupted sufficiently) Included in a fluoride mouth rinse programme (0.2% NaF) every 2 weeks; fluoride concentration of drinking water 0.1 - 0.2 ppm
  1. DS = Dataset number; BSL = Number of teeth at baseline; N = Number of teeth evaluated; n = Number of teeth with caries, LTF = Loss-to-follow-up; x = Mean; SD = Standard deviation; PG = Parallel group design; SM = Split-mouth design.
  2. 1 Different datasets reported from same trial
  3. 2 Number of pits reported, instead of the number of sealed teeth
  4. * Potential confounders = Reported fluoride exposure; high-sugary diet; poor oral hygiene; high past caries experience.