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Table 2 In vitro effects of two different concentrations of immunomodulatory drugs on TNF-α and IL-12 production by LCa

From: Effects of immunomodulatory drugs on TNF-α and IL-12 production by purified epidermal langerhans cells and peritoneal macrophages

 

Concentration

TNF-α (pg/ml)

IL-12 (pg/ml)

36 h cultured LC

-

21.8 ± 1.4

9.4 ± 0.5

Prednisone

10-6 M

10.8 ± 2.0*

2.9 ± 0.7**

 

10-8 M

9.5 ± 0.9*

4.0 ± 1.1**

Thalidomide

10-6 M

7.8 ± 1.7*

4.8 ± 0.5**

 

10-8 M

4.4 ± 3.8**

3.5 ± 1.8**

Cyclosporine A

10-6 M

5.8 ± 0.4**

8.7 ± 0.4

 

10-8 M

7.6 ± 0.5**

8.5 ± 0.6

Amitriptyline

10-6 M

9.7 ± 2.2*

6.4 ± 0.3*

 

10-8 M

12.2 ± 0.6*

7.4 ± 2.7

  1. aPurified LC were cultured for 36 h in the presence or absence of 10-6 M or 10-8 M prednisone, thalidomide, cyclosporine A, or amitriptyline. TNF-α and IL-12 levels in the culture supernatant were quantified by ELISA. All results are shown as mean ± SD for three independent experiments. *p < 0.05 vs. control. **p < 0.01 vs. control.
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BMC Research Notes

ISSN: 1756-0500

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