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Table 1 Summary of selected Canonical pathways

From: Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset

Pathway size by gene

Pathway overlapping

Gene mapping to pathway

Range

Proportion

Range

Proportion1

Range

Proportion

> = 10, < 20

36%

0

84%

Unique

26.20%

> = 20, < 100

55%

> 0, < 0.01

2.10%

> = 2, < 10

58.50%

> = 100, < 200

7.70%

> 0.01, < 0.1

11.30%

> = 10, < 100

15.10%

> = 200, < 300

1.30%

> 0.1, < 0.5

2.50%

> = 100

0.20%

  

> 0.5

0.10%

  
  1. Note 1: consider all possible pairs from of 854 canonical pathways; define the ratio as sharing count of genes out of all different genes for one pair of pathways (union overlap).
  2. A survey on 854 selected candidate pathways was conducted in order to investigate the characteristics of pathway size, pair-wise pathway overlap and gene allocation. Pathway size was measured by number of genes contained in the pathway; pathway overlapping was defined by the union overlapping ratio for one pair of pathways; gene allocation was counted as the number of pathways the genes belong to.