Skip to main content

Table 3 Predictors of serostatus

From: Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX

Pathogen Location
regression coefficient*
(p-value)
Sex
regression coefficient†
(p-value)
Age
regression coefficient
(p-value)
Education
regression coefficient
(p-value)
Income
regression coefficient
(p-value)
C. pneumoniae -0.919 (6.72 × 10 -4 ) 0.242 (0.023) -0.007 (0.021) 0.108 (0.095) 0.066 (0.238)
H. pylori -0.032 (0.832) 0.057 (0.454) -0.023 (4.49 × 10-24) 0.135 (0.004) 0.120 (0.005)
T. gondii 0.000 (0.998) 0.106 (0.315) -0.022 (1.29 × 10 -13 ) 0.120 (0.054) 0.201 (6.61 × 10-4)
CMV -0.291 (0.072) -0.181 (0.021) -0.031 (1.09 × 10 -38 ) -0.011 (0.809) 0.020 (0.647)
EBV -0.624 (3.89 × 10 -4 ) 0.151 (0.066) 0.001 (0.693) -0.002 (0.970) 0.034 (0.447)
HSV-1 -0.798 (4.37 × 10 -5 ) -0.008 (0.925) -0.009 (4.08 × 10 -4 ) 0.090 (0.084) 0.106 (0.029)
HSV-2 0.128 (0.350) -0.320 (2.19 × 10 -4 ) -0.018 (3.32 × 10 -13 ) 0.011 (0.822) 0.098 (0.033)
HHV-6 0.481 (8.97 × 10 -4 ) 0.194 (0.065) 0.021 (2.41 × 10 -13 ) -0.172(0.003) -0.118 (0.039)
VZV 0.230 (0.387) 0.150 (0.407) 0.000 (0.956) -0.071 (0.519) -0.181 (0.077)
Ad-36 -0.359 (0.011) -0.048 (0.607) 0.000 (0.991) 0.023 (0.671) 0.131 (0.010)
HAV -1.143 (2.29 × 10-7) -0.024 (0.770) -0.038 (8.58 × 10 -46 ) 0.132 (0.014) 0.062 (0.179)
Influenza A 0.149 (0.412) 0.206 (0.045) -0.005 (0.117) -0.087 (0.154) -0.083 (0.143)
Influenza B 0.632 (4.52 × 10 -5 ) 0.128 (0.136) 0.003 (0.267) -0.075 (0.147) -0.014 (0.769)
  1. All p-values in bold remain statistically significant after correcting for multiple testing across 13 pathogens using a conservative Sidàk correction.
  2. * Analysis of location compares 147 individuals in Mexico with 1,227 participants in the U.S. All remaining analyses presented in this table refer only to the 1,227 U.S. participants. Positive regression coefficient refers to higher seroprevalence in the U.S. compared to Mexico (e.g., HHV-6 seroprevalence is higher for U.S. participants).
  3. †Positive regression coefficient relates to a higher frequency in males compared to females (e.g., C. pneumoniae seroprevalence is higher in males).
  4. Serostatus is a discrete trait, and since we used a liability threshold model for analysis of such dichotomous traits within a variance components model for analysis of family data [29], the direction of effect of the predictor on the pathogen is opposite of the sign of the regression coefficient (e.g., H. pylori seroprevalence decreases with higher education).