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Table 1 In vitro antiplasmodial activity, cytotoxicity, and selectivity index of the plant extracts

From: In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

Plants species Voucher number Extract Antiplasmodial activity
(IC50, μg/ml)a
Cytotoxicity MRC-5 Selectivity Indexc
    FCB 3D7 (CC50 μg/ml)b FCB 3D7
Copaifera religiosa D. N. 584 CH2Cl2 13.4 ± 3.6 8.5 ± 4.7 4.87 ± 0.5 0.37 0.61
   CH3OH 500.7 ± 16.4 480.9 ± 34.2 NT ND ND
Tetrapleura tetraptera J.J. WIE 6388 CH2Cl2 10.1 ± 3.2 13.0 ± 5.1 79.9 ± 24.3 7.91 6.15
   CH3OH 34.6 ± 4.7 29.6 ± 6.9 89.4 ± 10.8 2.58 3.02
Chloroquine    324.8 ± 16.8 nM 7.9 ± 2.3 nM    
  1. a: IC50: (Inhibition concentration 50%) is the drug concentration that reduced parasitemia by 50%
  2. b: CC50: (Cytotoxic concentration drug 50%) is the drug concentration that reduced the number of viable MRC-5 cells by 50%
  3. c: Selectivity index = Ratio CC50/IC50
  4. NT: Not Tested
  5. ND: Not Determined