Figure 2

Neighborhood of over-represented pathways in the breast cancer signaling networks. The three significantly over-represented cell-cycle-related pathways' strict overlaps and the corresponding 1-extended nodes in the breast cancer signaling networks are connected, and a selected neighborhood of them is depicted in this figure. The pathways are "metaphase to anaphase transition", "cyclosome regulatory network" and "Aurora B cell cycle regulation". Those nodes of the strict network which belong to at least one of these pathways are depicted in green, those strict nodes which do not belong to a pathway are depicted in yellow, and those which belong to the 1-extended but not to the strict one in red. Inhibitory arcs are depicted in red, blue-colored arcs comprise non-inhibitory semantics such as activation and binding. The red nodes strongly enhance the network's connectivity. All paths from cyclosome to p53 pass at least one red node. The interaction between the three nodes Aurora B, cyclosome and p53, and thus the metaphase/anaphase-cell cycle-functional module only appears in the 1-extended network since securin, MAD2B and BRCA1, crucially involved in spindle assembly and spindle checkpoint, are not part of the strict but included in the 1-extended network.