Table 1 Baseline assessment of NESDO

Demographics: Age, gender, education, SES^a, religion, partner status, family

Standard questions

Diagnostics

Composite Interview Diagnostic Instrument (CIDI) -version 2.1 World Health Organization (WHO), 1997: depressive and anxiety disorders

Psychopathology

- Depression, severity

Inventory of Depressive Symptoms (IDS; Rush et al., 1996,

- Apathy, severity

Apathy Scale (Starkstein et al., 1992)

- Anxiety symptoms

Beck Anxiety Index (Beck et al., 1988)

Physical conditions

- Chronic diseases

LASA^a Questionnaire (Kriegsman et al., 1996)

- Pain

Chronic Graded Pain Scale (Von Korff & Miglioretti, 2005)

- Vision and hearing

LASA^a Questionnaires http://www.lasa-vu.nl/index.htm

- Sleep

Insomnia Rating Scale (Levine et al., 2003)

- Functional limitations

WHO-Disability Assessment Scale (Chwastiak et al., 2003)

- Medication use

Registration of medication use

- Smoking & drugs

Past & current smoking questions

- Alcohol dependency

Alcohol Use Disorders Identification Test (Babor et al., 1989)

- Physical Activities

International Physical Activities (Craig et al., 2003)

Biological determinants

- Inflammation markers, BDNF^a & polymorphism

Fasting blood sample

- Autonomic Nervous System

Electrocardiography & impedance cardiography (VU-AMS; de Geus et al., 1995)

- Cortisol

6 saliva samples, including Dexamethasone Suppression Test (Wüst et al., 2000; APA 1986)

Psychol. determinants

- Personality: Big Five

NEO-Five Factor Inventory (Costa & McCrae, 1995)

- Mastery

Pearlin Mastery scale (Pearlin & Schooler 1978)

- Daily Hassles

Worry Scale-R (Wisocki, 1986)

Social determinants

- Early life events

NEMESIS questionnaire (De Graaf et al., 2004)

- Recent life events

Brugha Questionnaire (Brugha et al., 1985)

- Loneliness and affiliation

Loneliness and affiliation scale (De Jong Gierveld & Kamphuis, 1995)

- Social support

Close Person Inventory (CPI; Stansfeld et al., 1992)

Cognitive functioning

- Global cognitive functioning

Mini-Mental State Examination (Folstein et al. 1975)

- Executive functioning

Stroop Color-Word test (short form) (Stroop 1935)

- Motivational problems

Digit Span (subtest WAIS^a) (Wechsler, 1958)

- Memory function

Auditory Verbal Learning Test (Rey, 1964; van der Elst et al. 2005)

Use of Care

Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness (Hakkaart-van Roijen, 2002)