Table 5 Correlations of the expression of Smad4, Smad6 and Smad7 with clinicopathological parameters in 25 patients of pancreatic ductal adenocarcinoma
Parameters | Groups | No.(n) | Loss/low expression of Smad4 (%) | P value (2-tailed) | Loss/low expression of Smad 6 (%) | P value | Loss/low expression of Smad7(%) | P value |
|---|---|---|---|---|---|---|---|---|
Age | < 50 | 5 | 4 (16%) | 1.000 | 4 (16%) | 0.244 | 4 (16%) | 1.000 |
≥ 50 | 20 | 16 (40%) | 10 (40%) | 16 (64%) | ||||
Sex | Male | 13 | 10 (40%) | 0.704 | 7(28%) | 0.830 | 10(40%) | 0.704 |
Female | 12 | 10 (40%) | 7 (28%) | 10 (40%) | ||||
Grade | G1 | 13 | 11 (44%) | 0.567 | 8 (32%) | 0.580 | 9 (36%) | 0.175 |
G2 | 12 | 9 (36%) | 6 (24%) | 11 (44%) | ||||
Stage | I+II | 10 | 7 (28%) | 0.328 | 5 (20%) | 0.639 | 8 (32%) | 1.000 |
III+IV | 15 | 13 (52%) | 9 (36%) | 12 (48%) | ||||
LN status | Negative | 19 | 15 (60%) | 0.824 | 9 (36%) | 0.132 | 15 (60%) | 0.824 |
Positive | 6 | 5 (20%) | 5 (20%) | 5(20%) | ||||
Tumor size | < 3 cm | 19 | 16 (64%) | 0.370 | 11(44%) | 0.747 | 17 (68%) | 0.036* |
≥3 cm | 6 | 4 (16%) | 3 (12%) | 3 (12%) | ||||
Margin status | Positive | 3 | 2 (8%) | 0.558 | 1(4%) | 0.420 | 1 (4%) | 0.032* |
Negative | 22 | 18 (72%) | 13 (52%) | 19 (76%) |