Figure 2

Locomotor activity and anxiety-like behavior. (A-H) Open field test: (A, E) total distance traveled, (B, F) vertical activity, (C, G) time spent in the center area, and (D, H) stereotypic counts were recorded. In each strain, there were no significant differences in the behavioral indices of the open field test between the genotypes. (I-L) Light/dark transition test: (I) distance traveled in the light/dark compartments, (J) time spent in the light compartment, (K) latency to enter the light compartment, and (L) number of light/dark transitions were recorded. 100P mutants traveled a higher distance in the light compartment and showed a higher number of transitions compared with the wild-type mice. (M-P) Elevated plus maze test: (M) distance traveled, (N) number of arm entries, (O) percentage of time spent in open arms, and (P) percentage of entries into the open arms were calculated. No genotype effects were found in this test. Data represent the mean ± SEM. The p values indicate a genotype effect in a t-test.