Table 3 Number and proportion of women reporting symptoms within past two weeks at the end of the first trial year in different trial arms, EPHT Trial
Symptom | Non-HT arms | HT arms | p-value* | OR (95 % CI)† |
|---|---|---|---|---|
Lack of energy | 347 (51.6%) | 379 (55.3%) | 0.173 | 1.16(0.94-1.44) |
Aches/stiffness in joints | 374 (55.6%) | 376 (54.8%) | 0.778 | 0.97(0.78-1.20) |
Backaches | 264 (39.2%) | 263 (38.3%) | 0.737 | 0.96(0.77-1.20) |
Headaches | 235 (34.9%) | 236 (34.4%) | 0.842 | 0.98(0.78-1.22) |
Irritability | 210 (31.2%) | 204 (29.7%) | 0.557 | 0.93(0.74-1.18) |
Sweating | 254 (37.7%) | 202 (29.5%) | 0.001 | 0.69(0.55-0.86) |
Trouble sleeping | 220 (32.7%) | 160 (23.3%) | <0.001 | 0.63(0.49-0.80) |
Diarrhoea or constipation | 155 (23.0%) | 158 (23.0%) | 1.000 | 1.00(0.78-1.29) |
Feeling blue or depressed | 142 (21.1%) | 149 (21.7%) | 0.780 | 1.04(0.80-1.34) |
Dizzy spells | 149 (22.1%) | 139 (20.3%) | 0.397 | 0.89(0.69-1.16) |
Water retention | 97 (14.4%) | 110 (16.0%) | 0.405 | 1.13(0.84-1.53) |
Sore throat | 67 (10.0%) | 88 (12.8%) | 0.096 | 1.33(0.95-1.86) |
Hot flashes | 219 (32.5%) | 82 (12.0%) | <0.001 | 0.28(0.21-0.37) |
Shortness of breath | 90 (13.4%) | 85 (12.4%) | 0.589 | 0.92(0.67-1.26) |
Persistent cough | 68 (10.1%) | 69 (10.1%) | 0.978 | 1.00(0.70-1.42) |
Upset stomach | 85 (12.6%) | 72 (10.5%) | 0.218 | 0.81(0.58-1.13) |
Loss of appetite | 22 (3.3%) | 20 (2.9%) | 0.707 | 0.89(0.48-1.65) |