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Table 3 Number and proportion of women reporting symptoms within past two weeks at the end of the first trial year in different trial arms, EPHT Trial

From: The effect of hormone therapy on women's quality of life in the first year of the Estonian Postmenopausal Hormone Therapy trial

Symptom Non-HT arms HT arms p-value* OR (95 % CI)
Lack of energy 347 (51.6%) 379 (55.3%) 0.173 1.16(0.94-1.44)
Aches/stiffness in joints 374 (55.6%) 376 (54.8%) 0.778 0.97(0.78-1.20)
Backaches 264 (39.2%) 263 (38.3%) 0.737 0.96(0.77-1.20)
Headaches 235 (34.9%) 236 (34.4%) 0.842 0.98(0.78-1.22)
Irritability 210 (31.2%) 204 (29.7%) 0.557 0.93(0.74-1.18)
Sweating 254 (37.7%) 202 (29.5%) 0.001 0.69(0.55-0.86)
Trouble sleeping 220 (32.7%) 160 (23.3%) <0.001 0.63(0.49-0.80)
Diarrhoea or constipation 155 (23.0%) 158 (23.0%) 1.000 1.00(0.78-1.29)
Feeling blue or depressed 142 (21.1%) 149 (21.7%) 0.780 1.04(0.80-1.34)
Dizzy spells 149 (22.1%) 139 (20.3%) 0.397 0.89(0.69-1.16)
Water retention 97 (14.4%) 110 (16.0%) 0.405 1.13(0.84-1.53)
Sore throat 67 (10.0%) 88 (12.8%) 0.096 1.33(0.95-1.86)
Hot flashes 219 (32.5%) 82 (12.0%) <0.001 0.28(0.21-0.37)
Shortness of breath 90 (13.4%) 85 (12.4%) 0.589 0.92(0.67-1.26)
Persistent cough 68 (10.1%) 69 (10.1%) 0.978 1.00(0.70-1.42)
Upset stomach 85 (12.6%) 72 (10.5%) 0.218 0.81(0.58-1.13)
Loss of appetite 22 (3.3%) 20 (2.9%) 0.707 0.89(0.48-1.65)
  1. * χ2-test.
  2. Non-HT arms as a reference group.
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