Table 2 The percentage changes from the baseline lung function parameters and VAS dyspnea scores after each of the six histamine doses
Mean values(± SD) | ||||||
|---|---|---|---|---|---|---|
| Â | dose step 1 | dose step 2 | dose step 3 | dose step 4 | dose step 5 | dose step 6 |
FEV1 | -12.0 ± 7.8 | -15.2 ± 10.1 | -17.4 ± 9.1 | -14.4 ± 6.8 | -18.8 ± 5.9 | -20.7 ± 4.5 |
FIV1 | -10.4 ± 8.4 | -14.1 ± 9.2 | -14.6 ± 9.2 | -17.6 ± 7.6 | -19.6 ±7.4 | -23.7 ± 15.3 |
IC | -12.4 ± 10.5 | -13.1 ± 13.6 | -11.7 ± 14 | -13.3 ± 8.2 | -16.3 ± 8.7 | -20.9 ± 14.0 |
FIF50 | -5.2 ± 11.3 | -6.0 ± 9.1 | -8.1 ± 12.4 | -4.2 ± 8.9 | -10.9 ± 8.2 | -24.0 ± 13.3 |
PIF | -7.3 ± 9.7 | -8.7 ± 8.2 | -11.6 ± 10 | -12.7 ± 8.1 | -14.7 ± 7.7 | -27.9 ± 16.9 |
VAS | 0.3 ± 1.0 | 0.7 ± 1.1 | 1.3 ± 0.9 | 1.3 ± 1.0 | 1.6 ± 1.2 | 1.2 ± 1.6 |
N1 | 39 | 32 | 20 | 9 | 7 | 4 |
N2 | 7 | 12 | 11 | 1 | 3 | 2 |