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Table 2 The percentage changes from the baseline lung function parameters and VAS dyspnea scores after each of the six histamine doses

From: The relationship between inspiratory lung function parameters and airway hyper-responsiveness in subjects with mild to moderate COPD

Mean values(± SD)
  dose step 1 dose step 2 dose step 3 dose step 4 dose step 5 dose step 6
FEV1 -12.0 ± 7.8 -15.2 ± 10.1 -17.4 ± 9.1 -14.4 ± 6.8 -18.8 ± 5.9 -20.7 ± 4.5
FIV1 -10.4 ± 8.4 -14.1 ± 9.2 -14.6 ± 9.2 -17.6 ± 7.6 -19.6 ±7.4 -23.7 ± 15.3
IC -12.4 ± 10.5 -13.1 ± 13.6 -11.7 ± 14 -13.3 ± 8.2 -16.3 ± 8.7 -20.9 ± 14.0
FIF50 -5.2 ± 11.3 -6.0 ± 9.1 -8.1 ± 12.4 -4.2 ± 8.9 -10.9 ± 8.2 -24.0 ± 13.3
PIF -7.3 ± 9.7 -8.7 ± 8.2 -11.6 ± 10 -12.7 ± 8.1 -14.7 ± 7.7 -27.9 ± 16.9
VAS 0.3 ± 1.0 0.7 ± 1.1 1.3 ± 0.9 1.3 ± 1.0 1.6 ± 1.2 1.2 ± 1.6
N1 39 32 20 9 7 4
N2 7 12 11 1 3 2
  1. Definition of abbreviations:
  2. FEV1 = forced expiratory volume in 1 second
  3. FIV1 = forced inspiratory volume in 1 second
  4. IC = inspiratory capacity (L)
  5. FIF50 = forced inspiratory flow at 50% of the vital capacity (L/s)
  6. PIF = peak inspiratory flow (L/s)
  7. VAS = VAS score for the change of dyspnea after each histamine dose
  8. N1 = number of subjects tested at the given histamine dose
  9. N2 = number of subjects with a FEV1 decrease from baseline of ≥ 20% at the given histamine dose.