Table 1 RNA sample list
Mouse suture tissues | ||||||
|---|---|---|---|---|---|---|
Time point | Genotype | Suture type | ||||
E16.5 * | Wildtype | Coronal, Posterior-frontal, Lambdoid, Parietal bone | ||||
D0 # | Wildtype | Coronal, Lambdoid | ||||
D0 | Fgfr2c C342Y/+ | Posterior frontal, Sagittal | ||||
D1 | Fgfr2c C342Y/+ | Coronal, Lambdoid | ||||
D5 | Wildtype | Lambdoid, Parietal bone | ||||
D5 | Fgfr2c C342Y/+ | Posterior frontal, Sagittal | ||||
D10 | Wildtype | Coronal, Lambdoid | ||||
D10 | Fgfr2c C342Y/+ | Posterior-frontal, Sagittal | ||||
Human suture cells | ||||||
Patient code | Phenotype | Sex | Age (months) | Suture type | Passage | |
AC 125 | Sagittal synostosis | M | 7 | Unfused Coronal | P5, P10 | |
AC 124 | Metopic synostosis | M | 7 | Unfused Coronal | P4, P8 | |
AC 126 | Metopic synostosis | F | 9 | Unfused Coronal | P4 | |
AC 141 | Sagittal synostosis | M | 6 | Unfused Coronal | P3 | |
AC 125 | Sagittal synostosis | M | 7 | Unfused Lambdoid | P4 | |
AC 120 | Crouzonoid syndrome | F | 96 | Fused Sagittal | P9 | |
AC 113 | Multi-suture synostosis | F | 10 | Fused Coronal | P5 | |
AC 34 | Multi-suture synostosis | F | 5 | Fusing Sagittal | P5 | |
Kusa 4b10 - Osteogenesis assay + | ||||||
Induced cells | Uninduced cells | |||||
- | 0 | |||||
3 | 3 | |||||
7 | 7 | |||||
14 | 14 | |||||
21 | 21 | |||||