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Table 5 miRNA expression. Average expression values at baseline, after 12 months and average expression change from baseline (delta values) in the vitamin D and placebo groups

From: Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months

  Vitamin D group*___________________________________________ Placebo group___________________________________________
  Baseline average expression (dCp) 12 months average expression (dCp) aAverage difference in expression (ddCp) Baseline average expression (dCp) 12 months average expression (dCp) aAverage difference in expression (ddCp)
let-7f 0.14
(−0.06, 0.39)
0.29
(−0.10, 0.45)
0.11
(−0.38, 0.37)
0.10
(−0.05, 0.30)
0.11
(−0.12, 0.29)
−0.12
(−0.34, 0.22)
let-7a 1.09
(0.86, 1.18)
1.06
(0.88, 1.27)
0.07
(−0.15, 0.26)
0.94
(0.82, 1.17)
1.02
(0.81, 1.19)
0.06
(−0.23, 0.23)
miR-151-5p −0.88
(−1.12, -0.68)
−0.90
(−1.08, -0.66)
0.04
(−0.26, 0.24)
−0.92
(−1.24, -0.76)
−1.14
(−1.35, -0.78)
−0.12
(−0.47, 0.17)
miR-22 −0.81
(−1.13, -0.57)
−0.91
(−1.17, -0.56)
−0.09
(−0.38, 0.29)
−0.72
(−1.12, -0.49)
−0.79
(−0.97, -0.48)
−0.04
(−0.19, 0.25)
miR-221 0.03
(−0.32, 0.29)
0.09
(−0.21, 0.27)
0.13
(−0.21, 0.29)
0.02
(−0.27, 0.26)
−0.28
(−0.58, 0.10)
−0.32
(−0.53, 0.10)
miR-26a 2.07
(1.90, 2.24)
2.09
(1.81, 2.25)
−0.02
(−0.29, 0.26)
1.94
(1.70, 2.11)
1.83
(1.53, 2.15)
−0.05
(−0.39, 0.25)
miR-28-5p −4.10
(−4.51, -3.66)
−4.11
(−4.48, -3.71)
0.09
(−0.60, 0.53)
−4.14
(−4.63, -3.93)
−4.30
(−4.55, -3.95)
−0.14
(−0.76, 0.32)
miR-532-3p −4.80
(−5.05, -4.37)
−4.68
(−4.84, -4.25)
0.06
(−0.46, 0.63)
−4.66
(−5,21, 4.24)
−4.63
(−5.03, -4.27)
0.19
(−0.45, 0.42)
miR-766 −3.53
(−3.97, -3.30)
−3.59
(−4.01, -3.32)
−0.11
(−0.39, 0.39)
−3.68
(−4.00, -3.41)
−3.72
(−4.14, -3.44)
−0.10
(−0.39, 0.18)
miR-99b −3.42
(−3.61, -3.12)
−3.34
(−3.73, -3.04)
0.03
(−0.42, 0.27)
−3.43
(−3.75, -3.14)
−3.42
(−3.91, -3.23)
0.04
(−0.33, 0.20)
  1. *19 subjects given 20.000 IU and 21 subjects given 40.000 IU vitamin D3 per week. a Average difference in expression values (average expression at 12 months minus average expression at baseline); b P = 0.03 vs baseline (Wilcoxon signed rank test); c P = 0.04 vs placebo group (Mann–Whitney U- test). Values are median (25, 75 percentile)