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Table 4 Studies on leptin in acute myocardial infarction

From: Elevated serum leptin levels in patients with acute myocardial infarction; correlation with coronary angiographic and echocardiographic findings

study patients conclusion
Hadi Khafaji et al. 2011 Qatarcurrent study 87 pts: 51 AMI pts + 36 matched control Leptin level is significantly correlated with BMI, CK, and LVEF. But neither with the type of MI (anterior vs. inferior) nor with the severity of angiographic findings and other echocardiographic parameters.
Yan GT,et al. * 2005 China [28] AMI and CS pts Leptin levels of both AMI & coronary atherosclerosis pts are significantly without a significant difference between each other, no correlation for leptin with CRP, TnT & endothelin
Krasnodebski et al. 2010 Poland [24] 58 patients with AMI Plasma leptin levels in diabetic pts are significantly in acute stage of AMI than in the period of convalescence.
Wallander M,et al. 2008Sweden [29] 181 AMI Circulating levels of leptin on the first morning after an AMI are associated with the presence of abnormal Glucose tolerance at discharge & with poor long-term prognosis.
Piestrzeniewicz et al. 2007 Poland [31] 40 obese and 40 non-obese men. Leptinemia is associated with fasting glucose, triglyceride levels, CRP & uric acid & negatively with HDL-C; leptin may be a pathogenetic factor in cardiovascular disease
Taneli et al. 2006 Turkey [30] 35 pts stable angina + 40 STEMI, + 30 control S. leptin is significantly in both stable angina &STEMI groups. No significant correlation between leptin levels & selected risk factors
Amasyali et al. 2006Turkey [25] 41 pts with AMI have thrombolysis Failure of reperfusion therapy with streptokinase is significantly in patients with admission plasma leptin ≥14 ng/mL vs. pts with admission plasma leptin <14 ng/mL.
Selvakumar et al. 2005 India [32] 94 pts with acute ST EMI + 46 controls leptin level is in patients with acute STEMI
Meisel et al. 2001 Isreal [26] 30 pts, AMI Leptin peaked on the 2nd day of hospitalization with a 2-fold from its baseline level on admission (p < 0.02). On day 3, leptin levels, & were 46%, 9%, &6% above baseline on days 3, 4 and 5, respectively.
Fujimaki et al. 2001 Japan [35] 21 AMI pts 15 control Hypoleptinaemic AMI pts had significantly plasma LDH vs. normoleptinaemic pts. No differences in other serum markers between normo vs. hyperleptinaemic AMI
Söderberg et al. 1999 Sweeden [33] 62 men with first-ever AMI High leptin (OR 8.97; 95% CI: 1.73-46.5) & cholesterol (OR 5.18; 95% CI: 1.34-20.0) levels significant risk factors for AMI in a multivariate model
Stejskal et al. 1988 Czech** [34] 16 AMI, 22 unstable angina Early after the acute coronary event, leptinemia in persons with AMI statistically positively correlated with concentration of interleukine-6 & subsequently of markers of coronary lesion severity (cTnI).
  1. *Article in Chinese, information taken from the abstract, ** Article in Czech information taken from the abstract.
  2. AMI: acute myocardial infarction, STEMI: STelevation myocardial infarction, cTnI): cardiac troponin I. BMI: Body mass index, CK: creatinine kinase, LVEF: left ventricular ejection fraction, HDL-C: high density lipoprotein cholesterol, LDH: lactate dehydrogenase, OR: odd rartio. CI confidence interval