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Table 1 Positive results in serological and real-time PCR assays are shown in bold

From: Diagnosis of HEV infection by serological and real-time PCR assays: a study on acute non-A-C hepatitis collected from 2004 to 2010 in Italy

Patient code Results of serological assaysa Results of real-time PCR (HEV-RNAb) HEV genotype Country of origin * ALT (UI/L)
Bioelisa HEV - IgM Bioelisa HEV - IgG
8 >3.000 >3.000 + + + 1a Italy (India) 2640
3 1.304 >3.000 + + + 1a Bangladesh 1726
12 >3.000 >3.000 + + +   India 1072
39 0.882 >3.000 + + +   India 2463
16 1.801 >3.000 + + 1a Bangladesh 1263
19 1.695 >3.000 + +   Bangladesh 835
22 >3.000 >3.000 + + 1a Italy (India) n.a.
43 0.508 >3.000 + +   Bangladesh 4515
47 0.867 >3.000 + +   Bangladesh 1683
48 2.709 >3.000 + +   Bangladesh 2050
52 0.869 >3.000 + + 1a Bangladesh 2496
55 1.316 >3.000 + +   India 1263
56 1.508 >3.000 + +   Bangladesh n.a.
58 0.793 2.070 + +   Italy (Thailand) 4044
60 2.665 0.775 + + 3e Italy 2010
7 0.498 >3.000 + +   India 486
51 >3.000 >3.000 + +   Italy n.a.
61 0.630 1.972 + + 1a Italy (India) 2472
10 2.388 >3.000 +   Ethiopia 5328
29 2.212 >3.000 +   Bangladesh n.a.
34 >3.000 2.969 +   Italy 855
63 0.102 0.088 + + +   Albania 597
33° 0.057 1.354 +   Italy 384
20° 0.653 0.151 -   Italy (Africa) over
30° 2.986 0.336 -   Pakistan n.a.
50° 0.480 0.081 -   Italy 3860
67° 0.546 0.000 -   Italy (Africa) 842
26° 0.271 0.814 -   n.a. 2050
28° 0.062 0.709 -   Bangladesh 806
32° 0.126 1.226 -   Italy 2391
  1. a Bioelisa HEV IgM, (cut-off = 0.421); Bioelisa HEV IgG, (cut-off = 0.574); Biokit.
  2. b +: 250 < copies/mL < 2,500; + +: 2,500 < copies/mL <25,000; + + +: >25,000 copies/mL; -: < 250 copies/mL.
  3. * All foreign patients either arrived in Italy or travelled to their country of origin less than one month before the onset of clinical symptoms. Travel to countries from endemic areas are indicated in brackets for Italian patients.
  4. n.a. : not available.
  5. °Serum was also analysed with HEV IgM Elisa MP Diagnostics (cut-off = 0.403); HEV IgM Elisa Wantai Biopharm (cut-off = 0.263). All samples were negative except sample 33 which showed OD values of 0.421 and 0.334 in MP Diagnostic and Wantai Biopharm assays, respectively.