Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes

Table 7 Minimal inhibitory concentration (MIC) of antibiotics in absence and presence extracts Tetrapleura tetraptera (μg/ml)

Bacterial strains	Antibiotics and MIC in absence and presenceTetrapleura tetraptera extract
	Ampicillin			Cefepime			Chloramphenicol			Ciprofloxacin			Cloxacillin
	Alone	MIC/2.5	MIC/5	Alone	MIC/2	MIC/5	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5
AG100Atet	-	-	-	-	-	-	256	256 (1) ^I	-	256	128 (2) ^S	128 (2)^S	-	-	-
AG102	-	-	-	128	256 (0.5)^I	256 (0.5) ^I	16	8 (2) ^S	8 (2) ^S	<2	<2	<2	-	-	-
CM64	-	-	-	-	-	-	nt	nt	nt	nt	nt	nt	-	-	-
KP63	-	-	-	256	256 (1) ^I	-	-	256 (>1) ^S	256 (>1) ^S	64	64 (1) ^I	64 (1) ^I	-	128 (>2) ^S	256 (>1) ^S
PA124	128	64 (2)^S	128 (1)^I	128	128 (1)^I	128 (1) ^I	32	4 (8) ^S	8 (4) ^S	16	16 (1) ^I	16 (1) ^I	-	-	-
Bacterial strains	Erythromycin			Kanamycin			Norfloxacin			Streptomycin			Tetracycline
Bacterial strains	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5	Alone	MIC/2.5	MIC/5
AG100Atet	64	64 (1) ^I	64 (1) ^I	-	256 (>1) ^S	256 (>1) ^S	128	128 (1) ^I	256 (0.5) ^I	<2	<2	<2	2	2 (1) ^I	2 (1) ^I
AG102	32	64 (0.5) ^I	64 (0.5) ^I	<2	<2	<2	<2	<2	<2	-	256 (>1) ^S	256 (>1) ^S	<2	<2	<2
CM64	-	256 (>1) ^S	-	4	4 (1) ^I	8 (0.5) ^I	4	4 (1) ^I	8 (0.5) ^I	32	16 (2) ^S	32 (1) ^I	nt	nt	nt
KP63	16	<1 (>16) ^S	8 (2) ^S	32	32 (1) ^I	64 (0.5) ^I	-	256 (>1) ^S	-	<4	<4	<4	<2	<2	<2
PA124	128	64 (2) ^S	64 (2) ^S	128	64 (2) ^S	64 (2) ^S	64	32 (2) ^S	64 (1) ^I	nt	nt	nt	8	2 (4) ^S	2 (4) ^S

MIC/2.5: concentration of plant extract added equal to 204.8 μg/mL for CM64 and to 409.6 μg/ml for AG100A_TET. PA124. KP63. AG102.
MIC/5: concentration of plant extract added equal to 102. 4 μg/mL for CM64; and to 204.8 μg/ml for AG100A_TET.PA124. KP63. AG102.
(): Folds decreasing of MIC. S: synergy. I: indifference. nt: not tested; (−): MIC > 256 μg/ml.

ISSN: 1756-0500