Table 1 Comparison of drug flux from gel
From: Effect of rubbing on the in vitro skin permeation of diclofenac-diethylamine 1.16% gel
Flux (μg/cm2/h) | Diclofenac 1.16% gel applied without rubbing (R) | Diclofenac 1.16% gel applied with rubbing (T) | Ratio (T/R) | ||
|---|---|---|---|---|---|
Time (h) | Mean | s.e.m | Mean | s.e.m | |
0 | 0.000 | 0.000 | 0.000 | 0.000 | 0.0 |
2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.0 |
4 | 0.000 | 0.000 | 0.000 | 0.000 | 0.0 |
8 | 0.003* | 0.003 | 0.018* | 0.007 | 5.2* |
24 | 0.027 | 0.006 | 0.035 | 0.007 | 1.3 |