Skip to main content

Advertisement

Table 5 The four most common haplotypes were comprised of the seven SNPs in the TLR4 gene.

From: The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

SNPs Haplotypes*
  1 2 3 4
rs10759930 T T C C
rs1927914 A A G G
rs12377632 C C T T
rs2149356 G G T T
rs11536889 C G G G
rs7037117 A A G A
rs7045953 A A A A
Freq. in emphysema 0.336 0.301 0.142 0.100
Freq. in control smokers 0.219 0.386 0.123 0.165
p(emphysema vs. controls) 0.004 0.051 0.538 0.039#
  1. The observed frequencies are shown for patients with the emphysema phenotype and control smokers
  2. Abbreviations: A adenine; C cytosine; Freq. frequency; G guanine; SNPs single nucleotide polymorphisms; T thymine; TLR4 Toll-like receptor 4
  3. *The designation of haplotype structure is given in Arabic numerals
  4. By chi-square test
  5. Odds Ratio = 1.80, 95% Confidence Intervals = 1.21- 2.70
  6. # Odds Ratio = 0.56, 95% Confidence Intervals = 0.33- 0.97