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Table 5 The four most common haplotypes were comprised of the seven SNPs in the TLR4 gene.

From: The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

SNPs

Haplotypes*

 

1

2

3

4

rs10759930

T

T

C

C

rs1927914

A

A

G

G

rs12377632

C

C

T

T

rs2149356

G

G

T

T

rs11536889

C

G

G

G

rs7037117

A

A

G

A

rs7045953

A

A

A

A

Freq. in emphysema

0.336

0.301

0.142

0.100

Freq. in control smokers

0.219

0.386

0.123

0.165

p†(emphysema vs. controls)

0.004‡

0.051

0.538

0.039#

  1. The observed frequencies are shown for patients with the emphysema phenotype and control smokers
  2. Abbreviations: A adenine; C cytosine; Freq. frequency; G guanine; SNPs single nucleotide polymorphisms; T thymine; TLR4 Toll-like receptor 4
  3. *The designation of haplotype structure is given in Arabic numerals
  4. † By chi-square test
  5. ‡Odds Ratio = 1.80, 95% Confidence Intervals = 1.21- 2.70
  6. # Odds Ratio = 0.56, 95% Confidence Intervals = 0.33- 0.97