Figure 5

Querying biotin-binding β -residue motifs (Case Study 2). The (a) streptavidin and (b) avidin biotin-binding motifs are well conserved with the residues on the binding face coloured red. (c) The minimal biotin-binding β-residue motif used to query potential biotin-binding proteins. (d) The query was matched in the gamma chain of the human complement C8 protein [PDB:1IW2]. The β-matrices shown in (a), (b), and (d) have been abbreviated for clarity and are sub-matrices of larger β-matrices.