Influence of the pedigree structure on the distribution of the LOD score under H
. Legend: Plots for the empirical distributions regarding the different pedigree sizes (P-values on a logarithmic scale) when the replicates are analyzed under the dominant, the additive and the recessive model. Horizontal gray lines refer to suggestive evidence for linkage (P-value of 0.0017), the classic 'LOD-3-criterion' (P-value of 0.0001), and significant evidence for linkage (P-value of 0.000049), respectively. The horizontal lines shown at the bottom of each graph represent the 95 % confidence interval at the LOD-3 level.