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Table 3 Breast cancer risk in relation to selected SNPs with regard to parity

From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer

Rs nr (Gene) p-value inter-action Case/ control N Nulliparous OR* (CI 95%) Case/ control N Parous OR* (CI 95%)
rs2981582 (FGFR2) 0.96     
CC   30/52 1.00 200/493 1.00
CT   36/69 0.90 (0.48-1.69) 310/571 1.36 (1.09-1.69)
TT   16/15 1.88 (0.78-4.52) 104/167 1.55 (1.15-2.10)
Per allele    1.25 (0.82-1.91)   1.27 (1.10-1.46)
rs1045485 (CASP8) 0.93     
CC   21/48 1.00 162/318 1.00
CG   7/14 1.08 (0.37-3.18) 35/71 1.03 (0.65-1.63)
GG   0/0 --- 8/10 1.68 (0.64-4.42)
Per allele    0.93 (0.31-2.83)   1.12 (0.79-1.58)
rs3803662 (TNRC9) 0.58     
CC   36/72 1.00 311/694 1.00
CT   33/54 1.32 (0.71-2.44) 238/446 1.17 (0.95-1.47)
TT   8/7 1.95 (0.61-6.29) 54/82 1.47 (1.01-2.14)
Per allele    1.33 (0.83-2.14)   1.19 (1.02-1.40)
rs8051542 (TNRC9) 0.15     
CC   14/38 1.00 177/399 1.00
CT   41/66 1.56 (0.73-3.36) 289/558 1.14 (0.91-1.44)
TT   23/28 2.18 (0.93-5.14) 120/234 1.14 (0.86-1.52)
Per allele    1.47 (0.96-2.24)   1.08 (0.94-1.24)
rs12443621 (TNRC9) 0.95     
AA   22/30 1.00 170/415 1.00
AG   35/79 0.68 (0.33-1.42) 295/565 1.28 (1.02-1.62)
GG   25/25 1.55 (0.67-3.61) 135/237 1.43 (1.08-1.89)
Per allele    1.25 (0.82-1.92)   1.20 (1.04-1.38)
rs889312 (MAP3K1) 0.11     
AA   42/67 1.00 273/653 1.00
AC   33/59 0.83 (0.46-1.53) 261/461 1.31 (1.06-1.62)
CC   4/10 0.49 (0.14-1.77) 61/103 1.47 (1.03-2.09)
Per allele    0.77 (0.48-1.24)   1.24 (1.07-1.45)
rs3817198 (LSP1) 0.48     
TT   37/68 1.00 271/591 1.00
CT   31/55 1.12 (0.60-2.11) 239/482 1.06 (0.85-1.31)
CC   8/4 4.38 (1.13-16.96) 68/100 1.48 (1.04-207)
Per allele    1.53 (0.93-2.51)   1.16 (0.99-1.35)
rs2107425 (H19) 0.12     
CC   44/57 1.00 311/570 1.00
CT   27/57 0.54 (0.28-1.05) 213/498 0.80 (0.65-1.00)
TT   4/14 0.35 (0.11-1.19) 64/127 0.94 (0.67-1.31)
Per allele    0.58 (0.36-0.95)   0.91 (0.78-1.06)
rs13281615 (8q24) 1.00     
AA   29/52 1.00 211/465 1.00
AG   37/61 1.11 (0.58-2.15) 290/558 1.18 (0.95-1.47)
GG   13/19 1.32 (0.55-3.15) 99/183 1.26 (0.93-1.70)
Per allele    1.14 (0.75-1.73)   1.13 (0.98-1.31)
rs981782 (5p12) 0.02     
TT   15/38 1.00 162/290 1.00
TG   43/72 1.67 (0.79-3.53) 303/595 0.85 (0.67-1.09)
GG   14/16 2.66 (0.99-7.12) 107/273 0.65 (0.48-0.87)
Per allele    1.64 (1.01-2.67)   0.81 (0.70-0.94)
rs30099 (5q) 0.47     
CC   66/101 1.00 505/1015 1.00
CT   14/34 0.68 (0.32-1.43) 97/205 0.95 (0.73-1.24)
TT   2/1 3.18 (0.26-39.46) 9/11 1.63 (0.66-4.06)
Per allele    0.89 (0.47-1.67)   1.02 (0.81-1.30)
rs4666451 (2p) 0.37     
GG   26/51 1.00 237/494 1.00
GA   38/54 1.39 (0.69-2.59) 256/502 1.08 (0.87-1.34)
AA   15/20 1.30 (0.54-3.10) 88/180 1.02 (0.75-1.38)
Per allele    1.17 (0.77-1.79)   1.02 (0.89-1.18)
rs13387042 (2q35) 0.79     
AA   22/35 1.00 164/292 1.00
AG   40/60 1.11 (0.55-2.25) 287/580 0.87 (0.68-1.11)
GG   16/36 0.69 (0.30-1.61) 140/308 0.80 (0.60-1.06)
Per allele    0.85 (0.56-1.28)   0.89 (0.78-1.03)
rs7766585 (ESR1) 0.10     
CC   63/97 1.00 443/907 1.00
CT   18/33 0.76 (0.39-1.51) 150/310 0.99 (0.79-1.24)
TT   0/6 ---- 17/20 1.91 (0.98-3.71)
Per allele    0.96 (0.82-1.12)   1.03 (0.97-1.10)
  1. *Adjusted for: age, year of inclusion in study, socioeconomic status and exposure to HRT.