Table 3 Breast cancer risk in relation to selected SNPs with regard to parity
From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer
Rs nr (Gene) | p-value inter-action | Case/ control N | Nulliparous OR* (CI 95%) | Case/ control N | Parous OR* (CI 95%) |
|---|---|---|---|---|---|
rs2981582 (FGFR2) | 0.96 | ||||
CC | 30/52 | 1.00 | 200/493 | 1.00 | |
CT | 36/69 | 0.90 (0.48-1.69) | 310/571 | 1.36 (1.09-1.69) | |
TT | 16/15 | 1.88 (0.78-4.52) | 104/167 | 1.55 (1.15-2.10) | |
Per allele | 1.25 (0.82-1.91) | 1.27 (1.10-1.46) | |||
rs1045485 (CASP8) | 0.93 | ||||
CC | 21/48 | 1.00 | 162/318 | 1.00 | |
CG | 7/14 | 1.08 (0.37-3.18) | 35/71 | 1.03 (0.65-1.63) | |
GG | 0/0 | --- | 8/10 | 1.68 (0.64-4.42) | |
Per allele | 0.93 (0.31-2.83) | 1.12 (0.79-1.58) | |||
rs3803662 (TNRC9) | 0.58 | ||||
CC | 36/72 | 1.00 | 311/694 | 1.00 | |
CT | 33/54 | 1.32 (0.71-2.44) | 238/446 | 1.17 (0.95-1.47) | |
TT | 8/7 | 1.95 (0.61-6.29) | 54/82 | 1.47 (1.01-2.14) | |
Per allele | 1.33 (0.83-2.14) | 1.19 (1.02-1.40) | |||
rs8051542 (TNRC9) | 0.15 | ||||
CC | 14/38 | 1.00 | 177/399 | 1.00 | |
CT | 41/66 | 1.56 (0.73-3.36) | 289/558 | 1.14 (0.91-1.44) | |
TT | 23/28 | 2.18 (0.93-5.14) | 120/234 | 1.14 (0.86-1.52) | |
Per allele | 1.47 (0.96-2.24) | 1.08 (0.94-1.24) | |||
rs12443621 (TNRC9) | 0.95 | ||||
AA | 22/30 | 1.00 | 170/415 | 1.00 | |
AG | 35/79 | 0.68 (0.33-1.42) | 295/565 | 1.28 (1.02-1.62) | |
GG | 25/25 | 1.55 (0.67-3.61) | 135/237 | 1.43 (1.08-1.89) | |
Per allele | 1.25 (0.82-1.92) | 1.20 (1.04-1.38) | |||
rs889312 (MAP3K1) | 0.11 | ||||
AA | 42/67 | 1.00 | 273/653 | 1.00 | |
AC | 33/59 | 0.83 (0.46-1.53) | 261/461 | 1.31 (1.06-1.62) | |
CC | 4/10 | 0.49 (0.14-1.77) | 61/103 | 1.47 (1.03-2.09) | |
Per allele | 0.77 (0.48-1.24) | 1.24 (1.07-1.45) | |||
rs3817198 (LSP1) | 0.48 | ||||
TT | 37/68 | 1.00 | 271/591 | 1.00 | |
CT | 31/55 | 1.12 (0.60-2.11) | 239/482 | 1.06 (0.85-1.31) | |
CC | 8/4 | 4.38 (1.13-16.96) | 68/100 | 1.48 (1.04-207) | |
Per allele | 1.53 (0.93-2.51) | 1.16 (0.99-1.35) | |||
rs2107425 (H19) | 0.12 | ||||
CC | 44/57 | 1.00 | 311/570 | 1.00 | |
CT | 27/57 | 0.54 (0.28-1.05) | 213/498 | 0.80 (0.65-1.00) | |
TT | 4/14 | 0.35 (0.11-1.19) | 64/127 | 0.94 (0.67-1.31) | |
Per allele | 0.58 (0.36-0.95) | 0.91 (0.78-1.06) | |||
rs13281615 (8q24) | 1.00 | ||||
AA | 29/52 | 1.00 | 211/465 | 1.00 | |
AG | 37/61 | 1.11 (0.58-2.15) | 290/558 | 1.18 (0.95-1.47) | |
GG | 13/19 | 1.32 (0.55-3.15) | 99/183 | 1.26 (0.93-1.70) | |
Per allele | 1.14 (0.75-1.73) | 1.13 (0.98-1.31) | |||
rs981782 (5p12) | 0.02 | ||||
TT | 15/38 | 1.00 | 162/290 | 1.00 | |
TG | 43/72 | 1.67 (0.79-3.53) | 303/595 | 0.85 (0.67-1.09) | |
GG | 14/16 | 2.66 (0.99-7.12) | 107/273 | 0.65 (0.48-0.87) | |
Per allele | 1.64 (1.01-2.67) | 0.81 (0.70-0.94) | |||
rs30099 (5q) | 0.47 | ||||
CC | 66/101 | 1.00 | 505/1015 | 1.00 | |
CT | 14/34 | 0.68 (0.32-1.43) | 97/205 | 0.95 (0.73-1.24) | |
TT | 2/1 | 3.18 (0.26-39.46) | 9/11 | 1.63 (0.66-4.06) | |
Per allele | 0.89 (0.47-1.67) | 1.02 (0.81-1.30) | |||
rs4666451 (2p) | 0.37 | ||||
GG | 26/51 | 1.00 | 237/494 | 1.00 | |
GA | 38/54 | 1.39 (0.69-2.59) | 256/502 | 1.08 (0.87-1.34) | |
AA | 15/20 | 1.30 (0.54-3.10) | 88/180 | 1.02 (0.75-1.38) | |
Per allele | 1.17 (0.77-1.79) | 1.02 (0.89-1.18) | |||
rs13387042 (2q35) | 0.79 | ||||
AA | 22/35 | 1.00 | 164/292 | 1.00 | |
AG | 40/60 | 1.11 (0.55-2.25) | 287/580 | 0.87 (0.68-1.11) | |
GG | 16/36 | 0.69 (0.30-1.61) | 140/308 | 0.80 (0.60-1.06) | |
Per allele | 0.85 (0.56-1.28) | 0.89 (0.78-1.03) | |||
rs7766585 (ESR1) | 0.10 | ||||
CC | 63/97 | 1.00 | 443/907 | 1.00 | |
CT | 18/33 | 0.76 (0.39-1.51) | 150/310 | 0.99 (0.79-1.24) | |
TT | 0/6 | ---- | 17/20 | 1.91 (0.98-3.71) | |
Per allele | 0.96 (0.82-1.12) | 1.03 (0.97-1.10) |