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Table 7 Summary of the RIs LFT analytes in cord and infant blood samples

From: Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

Analyte

 

n

Min. value

Max. value

DAP test

Mean (95% CI)

Lower limit (90% CI)

Upper limit (90%CI)

RI

Albumin (g/dl)

Combined

117

3.63

6.04

P = 0.341

4.84 (4.75-4.93)

3.88 (3.83-3.97)

5.82 (5.71-5.86)

3.88-5.82

Infants < 6 months  > 6 months

28 29

4.15 4.82

5.45 5.65

P = 0.475 P = 0.463

4.80 (4.66-4.95) 5.30 (5.22-5.39)

4.00 (3.85-4.12) 4.87 (4.72-4.95)

5.59 (5.50-5.76) 5.77 (5.71-5.89)

4.00-5.59 4.87-5.77

AST (U/l)

Combined

117

18

60

P = 0.204

35.9 (34.1-37.7)

16.1 (14.7-17.1)

55.4 (53.3-56.5)

16.1-55.4

Newborns Alcohol Yes  Alcohol No

11 49

34 18

54 53

P = 0.43 P = 0.36

45.5 (40.6-50.4) 36.2 (33.5-38.9)

28.2 (26.4-31.9) 17.4 (14.8-23)

63 (61.5-66.8) 55.7 (54.2-58.1)

28.2-63 17.4-55.7

ALT (U/l)

Newborns

60

5

23

P = 0.101

12.5 (11.1-13.8)

1.2 (0.08-3.06)

23.1 (21.4-24.8)

1.2-23.1

Infants Male Female

57 31 26

10 10 10

20 23 26

P = 0.095 P = 0.123 P = 0.435

16.2 (15.1-17.3) 15.1 (13.8-16.4) 17.6 (15.7-19.4)

6.94 (4.92-9.04) 6.5 (5.0-7.7) 7.7 (7.1-9.1)

24.8 (22.9-26) 22.1[14–17] 27.3 (25.6-29.7)

6.94-24.8 6.5-22.1 7.7-27.3

ALP (U/l)

Combined

117

163

954

P = 0.141

488 (456–520)

130 (112–155)

831 (781–848)

130-831

Newborns

        

 Alcohol Yes

11

163

418

P = 0.89

291 (241–341)

112 (78–133)

463 (435–513)

112-463

 Alcohol No

49

176

954

P = 0.82

385 (346–428)

180 (169–206)

808 (773–874)

180-808

GG (U/l)

Newborns

60

45

155

P = 0.320

96 (87.6-104)

30.6 (27.8-37.3)

160.7 (150–171)

30.6-160.7

Infants

57

11

26

P = 0.272

19 (17.9-20.2)

10 (9.2-12.4)

28.2 (26.8-29.4)

10-28.2

 < 6 months

28

14

26

P = 0.673

21.2 (20–22.4)

14.8 (13.5-15.9)

27.9 (26.6-29.6)

14.8-27.9

 > 6 months

29

11

26

P = 0.233

17 (15.2-18.7)

6.9 (1.9-8.0)

26.1 (23.5-28.2)

6.9-26.1

Direct bilirubin (mg/dl)

Combined

117

0.01

0.46

P = 0.075

0.18 (0.16-0.20)

−0.06 [−0.07]-[−0.04]

0.41 (0.39-0.43)

Below 0.41

Total bilirubin (mg/dl)

Combined

117

0.04

1.37

P = 0.130

0.69 (0.62-0.75)

−0.01 [−0.01]-[0.02]

1.37 (1.31-1.40)

Below 1.37

  1. LFT = Liver function tests, RI = Reference interval, AST = Aspartate aminotransferases, ALT = Alanine aminotransferases, GGT = γ- glutamyltransferases, ALP = Alkaline Phosphatase, n = number, min = minimum, max = maximum, CI = confidence interval, DAP = D’Agostino-Pearson.