From: Robust reference intervals for Liver function test (LFT) analytes in newborns and infants
Analyte | Â | n | Min. value | Max. value | DAP test | Mean (95% CI) | Lower limit (90% CI) | Upper limit (90%CI) | RI |
---|---|---|---|---|---|---|---|---|---|
Albumin (g/dl) | Combined | 117 | 3.63 | 6.04 | P = 0.341 | 4.84 (4.75-4.93) | 3.88 (3.83-3.97) | 5.82 (5.71-5.86) | 3.88-5.82 |
Infants < 6 months  > 6 months | 28 29 | 4.15 4.82 | 5.45 5.65 | P = 0.475 P = 0.463 | 4.80 (4.66-4.95) 5.30 (5.22-5.39) | 4.00 (3.85-4.12) 4.87 (4.72-4.95) | 5.59 (5.50-5.76) 5.77 (5.71-5.89) | 4.00-5.59 4.87-5.77 | |
AST (U/l) | Combined | 117 | 18 | 60 | P = 0.204 | 35.9 (34.1-37.7) | 16.1 (14.7-17.1) | 55.4 (53.3-56.5) | 16.1-55.4 |
Newborns Alcohol Yes  Alcohol No | 11 49 | 34 18 | 54 53 | P = 0.43 P = 0.36 | 45.5 (40.6-50.4) 36.2 (33.5-38.9) | 28.2 (26.4-31.9) 17.4 (14.8-23) | 63 (61.5-66.8) 55.7 (54.2-58.1) | 28.2-63 17.4-55.7 | |
ALT (U/l) | Newborns | 60 | 5 | 23 | P = 0.101 | 12.5 (11.1-13.8) | 1.2 (0.08-3.06) | 23.1 (21.4-24.8) | 1.2-23.1 |
Infants Male Female | 57 31 26 | 10 10 10 | 20 23 26 | P = 0.095 P = 0.123 P = 0.435 | 16.2 (15.1-17.3) 15.1 (13.8-16.4) 17.6 (15.7-19.4) | 6.94 (4.92-9.04) 6.5 (5.0-7.7) 7.7 (7.1-9.1) | 6.94-24.8 6.5-22.1 7.7-27.3 | ||
ALP (U/l) | Combined | 117 | 163 | 954 | P = 0.141 | 488 (456–520) | 130 (112–155) | 831 (781–848) | 130-831 |
Newborns | Â | Â | Â | Â | Â | Â | Â | Â | |
 Alcohol Yes | 11 | 163 | 418 | P = 0.89 | 291 (241–341) | 112 (78–133) | 463 (435–513) | 112-463 | |
 Alcohol No | 49 | 176 | 954 | P = 0.82 | 385 (346–428) | 180 (169–206) | 808 (773–874) | 180-808 | |
GG (U/l) | Newborns | 60 | 45 | 155 | P = 0.320 | 96 (87.6-104) | 30.6 (27.8-37.3) | 160.7 (150–171) | 30.6-160.7 |
Infants | 57 | 11 | 26 | P = 0.272 | 19 (17.9-20.2) | 10 (9.2-12.4) | 28.2 (26.8-29.4) | 10-28.2 | |
 < 6 months | 28 | 14 | 26 | P = 0.673 | 21.2 (20–22.4) | 14.8 (13.5-15.9) | 27.9 (26.6-29.6) | 14.8-27.9 | |
 > 6 months | 29 | 11 | 26 | P = 0.233 | 17 (15.2-18.7) | 6.9 (1.9-8.0) | 26.1 (23.5-28.2) | 6.9-26.1 | |
Direct bilirubin (mg/dl) | Combined | 117 | 0.01 | 0.46 | P = 0.075 | 0.18 (0.16-0.20) | −0.06 [−0.07]-[−0.04] | 0.41 (0.39-0.43) | Below 0.41 |
Total bilirubin (mg/dl) | Combined | 117 | 0.04 | 1.37 | P = 0.130 | 0.69 (0.62-0.75) | −0.01 [−0.01]-[0.02] | 1.37 (1.31-1.40) | Below 1.37 |