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Table 3 Association of genes SNPs with opiate drug dependence

From: Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent

Gene

SNP _ID

SNP

M_Aa

F_Ab

F_Uc

Pearson chi-square

p-value d

OR CMHe

DRD1

rs5326

G > A

A

0.172

0.144

1.32

0.256

0.256

DRD2

rs1800496

C > T

T

0.027

0.015

1.86

0.173

1.903

rs6277

T > C

T

0.427

0.460

1.05

0.307

0.873

rs2511521

T > C

G

0.370

0.383

0.16

0.685

0.946

rs12574471

C > T

T

0.196

0.161

1.85

0.173

1.265

rs2283265

G > T

T

0.146

0.087

8.70

0.001

2.785

rs6279

C > G

C

0.406

0.435

0.79

0.374

0.888

rs4581480

T > C

C

0.095

0.075

1.29

0.256

1.308

rs4350392

C > A

A

0.173

0.217

2.82

0.093

0.755

rs10891556

G > T

T

0.187

0.235

3.18

0.074

0.748

rs7103679

C > T

T

0.121

0.083

3.48

0.062

1.506

rs4938019

T > C

C

0.170

0.216

3.13

0.076

0.743

rs1076560

G > T

T

0.157

0.108

4.73

0.031

1.531

rs2075654

G > A

A

0.120

0.075

5.43

0.021

1.689

rs7125415

C > T

T

0.100

0.118

0.78

0.376

0.829

rs4648317

C > T

T

0.170

0.216

3.12

0.076

0.743

rs1125394

A > G

G

0.152

0.091

8.00

0.001

1.780

rs4648318

A > G

G

0.379

0.361

0.29

0.593

1.080

rs12363125

A > G

C

0.513

0.472

1.52

0.217

1.170

rs2734836

G > A

A

0.146

0.090

7.00

0.001

1.720

rs12364283

T > C

G

0.097

0.129

2.24

0.134

0.730

rs1799978

A > G

G

0.141

0.110

2.03

0.154

1.330

rs6275

C > T

T

0.404

0.429

0.60

0.440

0.900

rs1800497

C > T

T

0.195

0.156

2.37

0.123

1.310

 

rs1799732

-C

-C

0.146

0.067

21.00

0.260E-4

3.370

 

rs1800498

C > T

C

0.509

0.466

1.66

0.190

1.180

DRD3

rs6280

C > T

C

0.355

0.370

0.21

0.645

0.938

DRD4

rs3758653

C > T

C

0.263

0.287

0.66

0.410

0.886

DRD5

rs10033951

C > T

T

0.306

0.325

0.36

0.550

0.917

SLC6A3

rs2963238

A > C

A

0.436

0.462

0.63

0.427

0.899

rs6876225

C > A

A

0.027

0.035

0.49

0.480

0.764

rs11564773

A > G

G

0.043

0.437

0.00

0.978

0.991

rs1042098

T > C

C

0.363

0.342

0.42

0.515

1.094

BDNF1

rs7103873

C > G

C

0.463

0.510

2.02

0.154

0.827

rs1401635

C > G

C

0.231

0.212

0.50

0.481

1.118

rs11030102

C > G

G

0.163

0.138

1.17

0.279

1.221

rs17309930

A > C,G > T

A

0.136

0.127

0.17

0.679

1.084

rs6265

G > A

A

0.182

0.161

0.748

0.387

1.164

COMT

rs737866

T > C

C

0.363

0.312

2.69

0.100

1.259

 

rs4680

A > G

A

0.475

0.502

0.67

0.411

0.897

  1. a.M_A: minor allele for whole cohort sample.
  2. b.F_A: minor allele frequency in affected individuals (substance addiction cases).
  3. c.F_U: minor allele frequency in unaffected individuals (healthy controls).
  4. d.p-value: two tailed p-value from the 2x2 allele count chi-squared test; p <0.05 (Bonferroni-adjusted).
  5. e.OR CMH: allelic odds ratio from the 2x2xK Cochran-Mantel-Haenszel’s test.
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BMC Research Notes

ISSN: 1756-0500

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