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Table 3 Cross-sectional associations between oxidative stress (urinary F 2 -Isoprostanes) and eGFR cyst and albumin creatinine ratio (ACR) at age 77: Multivariable regression

From: Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study

  Cystatin c estimated glomerular filtration rate lnAlbumin creatinine ratio (ACR)
  total cohort (n = 647) eGFR > 60 ml/min/1.73 m2 (n = 514) total cohort (n = 647) ACR < 3 mg/mmol (n = 522)
  β-coefficient (95% CI) β-coefficient (95% CI) β-coefficient (95% CI) β-coefficient (95% CI)
Model A     
ln F2-isoprostane (nmol/mmol) 0.08 (0.006 to 0.16)* 0.04 (−0.03 to 0.11) −0.13 (−0.20 to −0.05) *** 0.004 (−0.04 to 0.05)
Model B (DAG adjusted)     
ln F2-isoprostane (nmol/mmol) 0.09 (0.02 to 0.17)* 0.03 (−0.03 to 0.10) −0.12 (−0.19 to −0.04) ** 0.0008 (−0.05 to 0.05)
Model C     
ln F2-isoprostane (nmol/mmol) 0.09 (0.01 to 0.16)* 0.03 (−0.04 to 0.10) −0.12 (−0.20 to −0.05) *** −0.001 (−0.05 to 0.05)
  1. Data are regression coefficients for a 1-SD urinary ln F2-isoprostanes. Model A was adjusted for age; model B was adjusted according to directed acyclic graphs (DAG): age, BMI, smoking, systolic and diastolic blood pressure, LDL, HDL, and triglyceride, statin treatment, ACE inhibitor-, ASA-, anti-inflammation-, and cortisone medication. Model C was adjusted for: age, BMI, smoking, systolic and diastolic blood pressure, hypertension treatment, LDL, HDL, and triglyceride, statin treatment, diabetes, ACE inhibitor-, ASA-, anti-inflammation-, and corticosteroid treatment, and CVD. * p < 0.05, **p < 0.01. *** p < 0.001.