(a) Macroscopic appearance. The tumor is on the tip of the left middle finger with deep ulceration at the center of the operation scar. (b) Histopathology of the tumor of the middle finger resected in 2010 showing well-differentiated SCC. Cancer cells have enlarged hyperchromatic nuclei and proliferate in verrucous structures or solid nests with apparent cancer pearls (hematoxylin and eosin staining, original magnification ×40). (c) Histopathology of the tongue tumor resected in 2007. Cancer cells show individual keratinization without definitive cancer pearls, indicating moderately-differentiated SCC (hematoxylin and eosin staining, original magnification ×40).